Pancuronium and a continuous infusion of althesin was used to produce muscular relaxation in a patient with myotonic dystrophy. Excellent muscle relaxation with absence of percussion or surgically induced myotonia was obtained but the EMG was not modified; an intracellular site of action of althesin is postulated. Cardiovascular stability was remarkable peroperatively; postoperatively an increased myocardial susceptibility to hypokalaemia was noticed.
References
1.
AdamsR. D., and TylerF. H. (1974): “Progressive Muscular Atrophy and Paralysis”, in Harrison's Principles of Internal Medicine, 7th Ed. WintrobeThorn, Adams (Eds.), McGraw-Hill, New York, p. 1927.
2.
GronertG. A., and TheyeR. A. (1976): “Dantrolene in Porcine Malignant Hyperthermia. Anesthesiology, 44, 488.
3.
HarrisonG. G. (1973): “Althesin and Malignant Hyperpyrexia”, Brit. J. Anaesth., 45, 1019.
4.
LaxenaireM. C., WeberM., MartinelleF., HottierM. C., PicardJ. M. (1974): Appreciation du Réveil par des Tests Psychomoteurs et l'EEG après Anesthésie à l'Alfatésine, Glaxo-France, Ed. p. 75.
5.
MillerJ., and KatzR. L. (1973): “Muscle Diseases”, in Anesthesia and Uncommon Diseases, Katz and Kadis (Eds). Saunders, Philadelphia, p. 428.
6.
SuppanP. (1975): “Althesin in Dystrophia Myotonica”, Anaesthesia, 30, 95.
7.
ThielR. E. (1967): “Myotonic Response to Succinylcholine”, Brit. J. Anaesth., 39, 815.
