The hypotensive effect of d-tubocurarine 0·5mg/kg, with and without benzyl alcohol and sodium metabisulphite as preservatives, was studied in 38 pairs of subjects in a double blind, controlled, sequential trial. It is concluded that the preservatives do not significantly contribute to the hypotension produced by d-tubocurarine in clinical practice.
References
1.
ArmitageP. (1960): Sequential Medical Trials, Blackwell, Oxford.
2.
CarrierO., and MurphyJ. C. (1970): “The effects of d-tubocurarine and its commercial vehicles on cardiac function”, Anesthesiology, 33, 627–634.
3.
CullenS. C. (1943): “The use of curare for the improvement of abdominal muscle relaxation during anaesthesia”, Surgery, 14, 148.
4.
DowdyE. G., DuggarP. N., and FabianL. W. (1965): “Effect of neuromuscular blocking agents on isolated digitalized mammalian hearts”, Anesth. Analg., 44, 608–617.
5.
DowdyE. G., HollandW. C., YamanakaI. (1971): Cardioactive properties of d-tubocurarine with and without preservatives”, Anesthesiology, 34, 256–261.
6.
GuytonA. C., and ReederR. C. (1950): “Quantitative studies on the autonomic action of curare”. J. Pharmacol. Exp. Ther., 98, 188.
7.
IwatsukiK., YusaT., and KataokaY. (1965): Effects of muscle relaxants on ventricular contractile force in dogs”, Tohoku J. Exp. Med., 86, 9.
8.
McCullochL. S., ReierC. E., DelaunoisA. L., GardierR. W., and HamelbergW. (1970): “The effects of d-tubocurarine on spontaneous postganglionic sympathetic activity and histamine release”, Anesthesiology, 33, 328–334.
9.
StoeltingR. K. (1971): “Blood-pressure responses to d-tubocurarine and its preservatives in anesthetised patients”, Anesthesiology, 35, 315–317.
