A bovine fetus aborted at 187 days of gestation was serologically and immunohistopathologically examined. Serum and cerebrospinal fluid samples had high titers of virus-neutralizing antibody for Aino virus. A severe necrotizing encephalopathy was noted. Aino virus antigen was demonstrated in neuroglial cells within the brain lesion. The destruction of developing neuronal cells appeared to be a significant feature of the pathogenesis of lesions due to Aino virus infection in the central nervous system.
CoverdaleORCybinskiDHGeorgeTDST:
Congenital abnormalities in calves associated with Akabane virus and Aino virus.
Aust Vet J54:151–152, 1978
2.
FukuyoshiSTakeharaYTakahashiKMoriR:
The incidence of antibody to Aino virus in animals and humans in Fukuoka.
Jpn J Med Sci34:41–43, 1981
3.
GotoYMiuraYKonoY:
Serologic evidence for the etiologic role and Chuzan virus in an epizootic of congenital abnormalities with hydranencephaly-cerebellar hypoplasia syndrome of calves in Japan.
Am J Vet Res49:2026–2029, 1988
4.
IshibashiiKAsadaKShirakawaHNakamuraHWatanabeA:
Isolation of Aino virus from a cow with astasia and leukopenia.
J Jpn Vet Med Assoc45:837–840, 1992
5.
IshibashiKShirakawaHUchinunoYOgawaT:
Seroprevalence survey of Aino virus infection in dairy cattle of Fukuoka, Japan in 1990.
J Vet Med Sci57:1–4, 1995
6.
KitanoYOhzonoHShimizuT:
Proliferation and teratogenicity of Aino virus in chick embryos.
Microbiol Immunol40:85–88, 1996
7.
KitanoYOhzonoHYasudaNShimizuT:
Hydranencephaly, cerebellar hypoplasia, and myopathy in chick embryos infected with Aino virus.
Vet Pathol33:672–681, 1996
8.
KurogiHInabaYGotoYMiuraYTakahashiHSatoKOmoriTMatsumotoM:
Serologic evidence for etiologic role of Akabane virus in epizootic abortion–arthrogryposis–hydranencephaly in cattle in Japan, 1972–1974.
Arch ges Virusforsch47:71–83, 1975
9.
MiuraYHayashiSIshiharaTInabaYOmoriTMatsumotoM:
Neutralizing antibody against Akabane virus in precolostral sera from calves with congenital arthrogryposis–hydranencephaly syndrome.
Arch ges Virusforsch46:377–380, 1974
10.
MiuraYKuboMGotoYKonoY:
Hydranencephaly–cerebellar hypoplasia in a newborn calf after infection of its dam with Chuzan virus.
Jpn J Vet Sci52:689–694, 1990
11.
MiuraYInabaYHayashiS:
A survey of neutralizing antibody against Aino virus in bovine serum in Kagoshima, Japan.
Natl Inst Anim Health Q (Jpn)20:34–35, 1989
12.
MoriwakiMMiuraYHayashiSIshitaniR:
Histopathological findings of calves infected experimentally with Aino virus.
Natl Inst Anim Health Q (Jpn)17:95–106, 1977
13.
NaritaMInuiSHashiguchiY:
The pathogenesis of congenital encephalopathies in sheep experimentally induced by Akabane virus.
J Comp Pathol89:229–240, 1979
14.
NaritaMKawashimaK:
Detection of Akabane viral antigen and immunoglobulin-containing cells in ovine fetuses by use of immunoperoxidase staining.
Am J Vet Res54:420–424, 1993
15.
ParsonsonIMDella-PortaAJMaPheeDA:
Pathogenesis and virulence studies of Australian Simbu serogroup Bunyaviruses. In:
Viral Disease in Southeast Asia and the Western Pacific,
pp. 644–647.
Academic Press, Victoria, Australia, 1982
