Forty children all aged over 2 years and eutrophic were treated with the combination amoxycillin and clavulanic acid for various infections (twenty-three with meningitis, eleven with bronchial pneumonia, three with typhoid fever, two with lower urinary tract infections and one with ear infection of moderate severity).
Nine of these patients had sickness during treatment which was mild and transient in the majority of cases and caused treatment to be stopped in only one case (2·5%). This low level of gastric tolerance should not concern the paediatrician faced with an infection due to (or most likely to be) a β-lactamase producing micro-organism.
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References
1.
AdamDDe VissierIKoeppeP (1982) Pharmacokinetics of amoxycillin and clavulanic acid administered alone and in combination. J. Antimicrob. Chemother. 22, 353.
2.
BallPWatsonTMehtarS (1981) Amoxycillin and clavulanic acid in intraabdominal and pelvic sepsis. J. Antimicrob. Chemother. 7, 441.
3.
BeeuwkesHRutgersV H (1981) A combination of amoxycillin and clavulanic acid in the treatment of respiratory tract infections caused by amoxycillin resistantHaemophilus Influenzae Infection9, 5.
4.
DebrayHGallandA (1982) Experience with Augmentin in the treatment of infections in children in “Augmentin, clavulanate-potentiated amoxycillin” Proc. of the Europ. Symp. Scheveningen, June 1982. Excerpta Medica ed.
5.
JacksonD (1980) Pharmacokinetics, toxicological and metabolic studies with Augmentin. Excerpta Med. Int. Cong. Ser.554, 87.
6.
KattamlsCSyriopoulouVPapagregoriou (1982) Effectiveness of Augmentin in the treatment of urinary tract infections in children in “Augmentin, clavulanate-potentiated amoxycillin” Proc. of the Europ. Symp. Scheveningen, June 1982. Excerpta Medica ed.
7.
LeighD ABradnockKMarrinerJ M (1981) Augmentin (amoxycillin and clavulanic acid) therapy in complicated infections due to β-lactamase producing bacteria. J A ntimicrob Chemother7, 229.
8.
NelsonJ DKusmiesZ HSheltonS (1982) Pharmacokinetics of potassium clavulanate in combination with amoxycillin in paediatric patients. J Antimicrob Chemother21, 681.
9.
PriceJ D (1982) Augmentin: a review of paediatric clinical evaluations in the UK including a survey of bacteriological isolates and clinical efficacy and safety. Proc. of the 22nd ICAAC, Miami.
10.
Tazi-LakhsassiLBenbachirMEl MdaghriN (1985) Amoxicilline orale dans les méningites purulentes de l'enfant, relais précoce et réduction des posologies. J lnt Med Res13, 188.
11.
ThabautADurosoirJ LSaliouP (1981) Activité in vitro de l'association acide clavulanique amoxicilline sur 335 souches d'entéro-bactéries et de Staphylococcus auréus resistant a l'amoxicilline. Med Mal Inf11, 588.
12.
WatsonAMahendraM (1980) A multicentre therapeutic study of Augmentin in infections presenting in general practice in “Augmentin, clavulanate-potentiated amoxycillin” Proc. of the 1st Symp. Amsterdam, July 1980. Excerpta Medica ed.
