This multicentre, open study was conducted in 263 hypertensive patients from six different countries by seventeen investigators. The results confirm the efficacy and safety of nadolol, used alone or in combination therapy in the treatment of hypertension, even inpatients in whom previous antihypertensive therapy with other drugs was unsatisfactory. The study also demonstrated that nadolol can effectively replace a variety of other antihypertensive agents, and, because of once a day dosage, can enhance patient compliance and produce better therapeutic responses.
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