Eleven patients suffering from osteoarthritis of the cervical spine were admitted to a pilot study aimed at establishing the effective dose and the tolerability of Nimesulide.
The patients received a basic treatment of Nimesulide 100 mg/day, increasable up to 300 mg/day, in conformity with the patient's need.
The treatment over a period of 15 days showed that Nimesulide 200 mg/day has good anti-inflammatory and analgesic properties. Several critical parameters were significantly improved. The incidence of usually mild side-effects was very low.
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References
1.
Council for International Organisations of Medical Sciences (1963) Atlas of Standard Radiographs of Arthritis. Vol. 2. Blackwell, Oxford.
2.
CuthbertMF (1974) Adverse reactions to non-steroidal anti-rheumatic drugs. Current Medical Research and Opinion2, 600.
3.
DieppeP AHuskissonE CWilloughbyD A (1980) The inflammatory component of osteoarthritis. In: The Aetiopathogenesis of Osteoarthrosis. Editor NukiG. Pitman Medical Research Press, Bath, England. p 117.
4.
GamarskiJ (1981) The treatment of degenerative arthropathies with Nimesulide. Revista Brasileira de Medicina, 38, 5, 309.
5.
GrantT JMooreG G ISwingleK F (1975) Anti-inflammatory activity of 4-nitro-2-phenoxymethanesulfonanilide. Federation Proceeding, 34 (3), 759.
6.
HartF D (1975) Inflammatory disease and its control in rheumatic disorders. British Medical Journal4, 191.
7.
Leading Article (1976) Antirheumatic drugs: Plenty is not enough. British Medical Journal1, 59.
8.
MoskowitzR W (1972) Clinical and laboratory findings in osteoarthritis. In: Arthritis and Allied Conditions. 8th ed., HollanderJ LMcCartyD J. Editors Philadelphia, Dea and Febiger. p 1032.
9.
Various (1976) Clinical Trial Certificate Application Dossier Volume 3. Animal Toxicology. Biex Solaris File.
10.
VigdahlR LTukeyR H (1975) Inhibition of prostaglandin synthesis by anti-inflammatory agents R-805 and R-807. Pharmacologist, 17 (2), 226.
11.
VigdahlR LTukeyR H (1977) Mechanism of action of novel anti-inflammatory drugs diflumidone and R-805. Biochemical Pharmacology, 26 (4), 307.
12.
WeissenbachR (1981) Clinical trial with Nimesulide, a new non-steroid, anti-inflammatory agent, in rheumatic pathology. The Journal of International Medical Research9, 349.