Lorazepam in Anxiety: A Controlled Study

Abstract

Lorazepam (3 mg/day) was compared to placebo in a double-blind controlled study conducted with anxious neurotic out-patients. Sixty-eight patients were treated for at least two weeks. Significant main treatment effects were found with lorazepam producing more improvement than placebo in physician but not patient-completed measures. Lorazepam seemed to be most effective in the initially sicker patients. Its main side-effect was sedation.