Forty patients have been treated for two months with fluspirilene, a new injectable diphenylbutylpiperidine administered intramuscularly once per week. Chronic cases improved satisfactorily and acute cases did rather better, particularly in relation to delusions.
When the average dose was low (5.4 mg) extra-pyramidal effects were uncommon, but if 12 mg was given, more side-effects were encountered. Two patients on fluspirilene 4 mg weekly had dystonic reactions.
If marked hypertension was present, the systolic pressure fell by about 60 mm Hg.
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References
1.
AmeryWOnkenhoutL ASchefferW (1970) Clinical study of an injectable long-acting neuroleptic agent: Fluspirilene (R 6218). Psychialria Neurologia and Neurochirurgia73, 285–291.
2.
AnanthJ VBanT AChouinardGLehmannH E (1970) Fluspirilene in the treatment of chronic schizophrenic patients. Current Therapeutic Research12, 604–608.
3.
AndenN EButcherS GCorrodiHFuxeKUngerstedtU (1970) Receptor activity and turnover of dopamine and noradrenaline after neuroleptics. European Journal of Pharmacology11, 303–314.
4.
BrugmansJGeversFSterkmansP (1969) Clinical evaluation of Fluspirilene (R 6218): A long-acting injectable neuroleptic. Clinical Trials Journal6, 19–25.
5.
DoganKLachanceRProulxCVilleneuveA (1970) A controlled study of Fluspirilene in chronic schizophrenia. Current Therapeutic Research12, 819–827.
6.
EckmannFVon ImmichHNeumannHSchäpperleOSchwarzHTempelH (1970) Klinische Gemeinschaftsuntersuchung mit dem Langzeit-Neurolepticum Fluspirilene. Arzneimittel Forschung, (Drug Research)20, 1699–1701.
7.
FrankThHaaseH JKnaackC LRichter-PeillH (1968) Klinische Prüfung eines neuen Langzeitneuroleptikums (Fluspirilene) unter besonderer Berücksichtigung der neuroleptischen Schwelle. Der Nervenarzt6, 275–279.
8.
HerinV VJanssenP A JLenaertsF MMacsboomR H MNiemegeersC J EVan NuetenJ MSchaperW K ASchellekensK H LVerbruggenF J (1970) The pharmacology of Fluspirilene (R 6218), a potent, long-acting and injectable neuroleptic drug. Arzneimittel Forschung (Drug Research)20, 1689–1698.
9.
Multi-Centre Study (1971) Pimozide as maintenance treatment in chronic schizophrenia. British Journal of Clinical Practice25, 417–420.
10.
TangheAVereeckenJ L Th M (1972) Fluspirilene and Pipothiazine Undecylenate, two long-acting injectable neuroleptics: A double-blind controlled trial in residual schizophrenia. Psychialria, Neurologia Neurochirurgia (Amsterdam), 75, 117–127.
11.
Van EpenJ H (1970) Experience with Fluspirilene (R 6218), a long-acting neuroleptic. Psychialria, Neurologia and Neurochirurgia73, 277–284.
