MicroRNAs (miRNA) are endogenously produced small, non-coded, single-stranded RNAs. Due to their involvement in various cellular processes and cross-communication with extracellular components, miRNAs are often coined the “grand managers” of the cell. miRNAs are frequently involved in upregulation as well as downregulation of specific gene expression and thus, are often found to play a vital role in the pathogenesis of multiple diseases. Central nervous system (CNS) diseases prove fatal due to the intricate nature of both their development and the methods used for treatment. A considerable amount of ongoing research aims to delineate the complex relationships between miRNAs and different diseases, including each of the neurological disorders discussed in the present review. Ongoing research suggests that specific miRNAs can play either a pathologic or restorative and/or protective role in various CNS diseases. Understanding how these miRNAs are involved in various regulatory processes of CNS such as neuroinflammation, neurovasculature, immune response, blood-brain barrier (BBB) integrity and angiogenesis is of empirical importance for developing effective therapies. Here in this review, we summarized the current state of knowledge of miRNAs and their roles in CNS diseases along with a focus on their association with neuroinflammation, innate immunity, neurovascular function and BBB.
RoitbakT.MicroRNAs and regeneration in animal models of CNS disorders. Neurochem Res2020;
45: 188–203.
2.
BartelDPChenCZ.Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nat Rev Genet2004;
5: 396–400.
3.
SunWJulie LiYSHuangHD, et al.
microRNA: a master regulator of cellular processes for bioengineering systems. Annu Rev Biomed Eng2010;
12: 1–27.
4.
RaoPBenitoEFischerA.MicroRNAs as biomarkers for CNS disease. Front Mol Neurosci2013;
6: 39.
5.
HusseinMMagdyR.MicroRNAs in Central nervous system disorders: current advances in pathogenesis and treatment. Egypt J Neurol Psychiatry Neurosurg2021;
57: 1–11.
6.
NejadCStundenHJGantierMP.A guide to miRNAs in inflammation and innate immune responses. Febs J2018;
285: 3695–3716.
7.
O'ConnellRMChaudhuriAARaoDS, et al.
MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output. Proc Natl Acad Sci U S A2010;
107: 14235–14240.
8.
LeeRCFeinbaumRLAmbrosV.The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell1993;
75: 843–854.
9.
O'BrienJHayderHZayedY, et al.
Overview of MicroRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol (Lausanne)2018;
9: 402.
10.
BhaskaranMMohanM.MicroRNAs: history, biogenesis, and their evolving role in animal development and disease. Vet Pathol2014;
51: 759–774.
11.
PasquinelliAEReinhartBJSlackF, et al.
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature2000;
408: 86–89.
12.
SunPLiuDZJicklingGC, et al.
MicroRNA-based therapeutics in central nervous system injuries. J Cereb Blood Flow Metab2018;
38: 1125–1148.
13.
VasudevanSTongYSteitzJA.Switching from repression to activation: microRNAs can up-regulate translation. Science2007;
318: 1931–1934.
14.
FabbriM.MicroRNAs and miRceptors: a new mechanism of action for intercellular communication. Philos Trans R Soc Lond B Biol Sci2018;
373: 20160486.
15.
Momen-HeraviFBalaS.miRNA regulation of innate immunity. J Leukoc Biol2018;
6: 20180414.
16.
YuanXBergNLeeJW, et al.
MicroRNA miR-223 as regulator of innate immunity. J Leukoc Biol2018;
104: 515–524.
17.
GantierMPStundenHJMcCoyCE, et al.
A miR-19 regulon that controls NF-kappaB signaling. Nucleic Acids Res2012;
40: 8048–8058.
18.
LaiNWuDLiangT, et al.
Systemic exosomal miR-193b-3p delivery attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage in mice. J Neuroinflammation2020;
17: 74.
19.
HuJZhaiCHuJ, et al.
MiR-23a inhibited IL-17-mediated proinflammatory mediators expression via targeting IKKalpha in articular chondrocytes. Int Immunopharmacol2017;
43: 1–6.
20.
ZhuSPanWSongX, et al.
The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-alpha. Nat Med2012;
18: 1077–1086.
21.
TengGGWangWHDaiY, et al.
Let-7b is involved in the inflammation and immune responses associated with Helicobacter pylori infection by targeting toll-like receptor 4. PLoS One2013;
8: e56709.
22.
CurtaleGMiroloMRenziTA, et al.
Negative regulation of toll-like receptor 4 signaling by IL-10-dependent microRNA-146b. Proc Natl Acad Sci U S A2013;
110: 11499–11504.
23.
FangCLiQMinG, et al.
MicroRNA-181c ameliorates cognitive impairment induced by chronic cerebral hypoperfusion in rats. Mol Neurobiol2017;
54: 8370–8385.
24.
MinHJangYHChoIH, et al.
Alternatively activated brain-infiltrating macrophages facilitate recovery from collagenase-induced intracerebral hemorrhage. Mol Brain2016;
9: 42.
25.
WalshKBCamposBHartK, et al.
M2 monocyte microparticles are increased in intracerebral hemorrhage. J Stroke Cerebrovasc Dis2017;
26: 2369–2375.
26.
JablonskiKAGaudetADAmiciSA, et al.
Control of the inflammatory macrophage transcriptional signature by miR-155. PLoS One2016;
11: e0159724.
27.
ZingaleVDGugliandoloAMazzonE.MiR-155: an important regulator of neuroinflammation. Int J Mol Sci2021;
23: 20211222.
28.
WangXChenSNiJ, et al.
miRNA-3473b contributes to neuroinflammation following cerebral ischemia. Cell Death Dis2018;
9: 11.
ForroTBajkoZBalasaA, et al.
Dysfunction of the neurovascular unit in ischemic stroke: highlights on microRNAs and exosomes as potential biomarkers and therapy. Int J Mol Sci2021;
22: 5621.
31.
FishJESantoroMMMortonSU, et al.
miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell2008;
15: 272–284.
32.
SongHZhangXChenR, et al.
Cortical Neuron-Derived exosomal MicroRNA-181c-3p inhibits neuroinflammation by downregulating CXCL1 in astrocytes of a rat model with ischemic brain injury. Neuroimmunomodulation2019;
26: 217–233.
33.
PeiXLiYZhuL, et al.
Astrocyte-derived exosomes transfer miR-190b to inhibit oxygen and glucose deprivation-induced autophagy and neuronal apoptosis. Cell Cycle2020;
19: 906–917.
34.
LiuXFengZDuL, et al.
The potential role of MicroRNA-124 in cerebral ischemia injury. Int J Mol Sci2019;
21: 20191223.
35.
QuMPanJWangL, et al.
MicroRNA-126 regulates angiogenesis and neurogenesis in a mouse model of focal cerebral ischemia. Mol Ther Nucleic Acids2019;
16: 15–25.
36.
LiangZChiYJLinGQ, et al.
MiRNA-26a promotes angiogenesis in a rat model of cerebral infarction via PI3K/AKT and MAPK/ERK pathway. Eur Rev Med Pharmacol Sci2018;
22: 3485–3492.
37.
GugliandoloASilvestroSSindonaC, et al.
MiRNA: involvement of the MAPK pathway in ischemic stroke. A promising therapeutic target. Medicina (Kaunas)2021;
57: 20211001.
38.
RuoziBBellettiDBondioliL, et al.
Neurotrophic factors and neurodegenerative diseases: a delivery issue. Int Rev Neurobiol2012;
102: 207–247.
39.
NumakawaTRichardsMAdachiN, et al.
MicroRNA function and neurotrophin BDNF. Neurochem Int2011;
59: 551–558.
40.
LiYJXuMGaoZH, et al.
Alterations of serum levels of BDNF-related miRNAs in patients with depression. PLoS One2013;
8: e63648.
41.
HuJHuangCXRaoPP, et al.
Inhibition of microRNA-155 attenuates sympathetic neural remodeling following myocardial infarction via reducing M1 macrophage polarization and inflammatory responses in mice. Eur J Pharmacol2019;
851: 122–132.
42.
RisbudRMLeeCPorterBE.Neurotrophin-3 mRNA a putative target of miR21 following status epilepticus. Brain Res2011;
1424: 53–59.
43.
YuZWillmarthNEZhouJ, et al.
microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling. Proc Natl Acad Sci U S A2010;
107: 8231–8236.
44.
PiotrzkowskaDMillerEKucharskaE, et al.
Association of miRNA and mRNA levels of the clinical onset of multiple sclerosis patients. Biology (Basel)2021;
10: 10.
45.
KonovalovaJGerasymchukDArroyoSN, et al.
Human-specific regulation of neurotrophic factors MANF and CDNF by microRNAs. Int J Mol Sci2021;
22: 20210907.
46.
TakataFNakagawaSMatsumotoJ, et al.
Blood-brain barrier dysfunction amplifies the development of neuroinflammation: Understanding of cellular events in brain microvascular endothelial cells for prevention and treatment of BBB dysfunction. Front Cell Neurosci2021;
15: 661838.
47.
WangJXuFZhuX, et al.
Targeting microRNAs to regulate the integrity of the blood-brain barrier. Front Bioeng Biotechnol2021;
9: 673415.
48.
ChakrabortyCSharmaARSharmaG, et al.
MicroRNAs: possible regulatory molecular switch controlling the BBB microenvironment. Mol Ther Nucleic Acids2020;
19: 933–936.
49.
ZuoXLuJManaenkoA, et al.
MicroRNA-132 attenuates cerebral injury by protecting blood-brain-barrier in MCAO mice. Exp Neurol2019;
316: 12–19.
50.
XuBZhangYDuXF, et al.
Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity. Cell Res2017;
27: 882–897.
51.
MaQDasguptaCLiY, et al.
MicroRNA-210 suppresses junction proteins and disrupts Blood-Brain barrier integrity in neonatal rat Hypoxic-Ischemic brain injury. Int J Mol Sci2017;
18: 20170624.
52.
MaFSunPZhangX, et al.
Endothelium-targeted deletion of the miR-15a/16-1 cluster ameliorates blood-brain barrier dysfunction in ischemic stroke. Sci Signal2020;
13: 20200407.
53.
ZhangTTianCWuJ, et al.
MicroRNA-182 exacerbates blood-brain barrier (BBB) disruption by downregulating the mTOR/FOXO1 pathway in cerebral ischemia. Faseb J2020;
34: 13762–13775.
54.
GeXHuangSGaoH, et al.
miR-21-5p alleviates leakage of injured brain microvascular endothelial barrier in vitro through suppressing inflammation and apoptosis. Brain Res2016;
1650: 31–40.
55.
LiJZhaoYLuY, et al.
The poly-cistronic miR-23-27-24 complexes target endothelial cell junctions: Differential functional and molecular effects of miR-23a and miR-23b. Mol Ther Nucleic Acids2016;
5: e354.
56.
TominagaNKosakaNOnoM, et al.
Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier. Nat Commun2015;
6: 6716.
57.
ZhengZChoppMChenJ.Multifaceted roles of pericytes in central nervous system homeostasis and disease. J Cereb Blood Flow Metab2020;
40: 1381–1401.
58.
DemolliSDoddaballapurADevrajK, et al.
Shear stress-regulated miR-27b controls pericyte recruitment by repressing SEMA6A and SEMA6D. Cardiovasc Res2017;
113: 681–691.
59.
FangZHeQWLiQ, et al.
MicroRNA-150 regulates blood-brain barrier permeability via tie-2 after permanent Middle cerebral artery occlusion in rats. Faseb J2016;
30: 2097–2107.
60.
KuriakoseDXiaoZ.Pathophysiology and treatment of stroke: present status and future perspectives. Int J Mol Sci2020;
21: 20201015.
61.
DuKZhaoCWangL, et al.
MiR-191 inhibit angiogenesis after acute ischemic stroke targeting VEZF1. Aging (Albany NY)2019;
11: 2762–2786.
62.
LiuLZLiCChenQ, et al.
MiR-21 induced angiogenesis through AKT and ERK activation and HIF-1alpha expression. PLoS One2011;
6: e19139.
63.
LiLDongLZhaoJ, et al.
Circulating miRNA-3552 as a potential biomarker for ischemic stroke in rats. Biomed Res Int2020;
2020: 4501393.
64.
KoutsisGSiasosGSpengosK.The emerging role of microRNA in stroke. Curr Top Med Chem2013;
13: 1573–1588.
65.
HarrazMMEackerSMWangX, et al.
MicroRNA-223 is neuroprotective by targeting glutamate receptors. Proc Natl Acad Sci U S A2012;
109: 18962–18967.
66.
FuXNiuTLiX.MicroRNA-126-3p attenuates intracerebral Hemorrhage-Induced blood-brain barrier disruption by regulating VCAM-1 expression. Front Neurosci2019;
13: 866.
67.
WangSOlsonEN.AngiomiRs–key regulators of angiogenesis. Curr Opin Genet Dev2009;
19: 205–211.
68.
TsaiYHWuMFWuYH, et al.
The M type K15 protein of Kaposi's sarcoma-associated herpesvirus regulates microRNA expression via its SH2-binding motif to induce cell migration and invasion. J Virol2009;
83: 622–632.
69.
StamatovicSMPhillipsCMMartinez-RevollarG, et al.
Involvement of epigenetic mechanisms and non-coding RNAs in Blood-Brain barrier and neurovascular unit injury and recovery after stroke. Front Neurosci2019;
13: 864.
ZhaoYJaberVAlexandrovPN, et al.
microRNA-Based biomarkers in Alzheimer's disease (AD). Front Neurosci2020;
14: 585432.
72.
RenZYuJWuZ, et al.
MicroRNA-210-5p contributes to cognitive impairment in early vascular dementia rat model through targeting Snap25. Front Mol Neurosci2018;
11: 388.
73.
KangQXiangYLiD, et al.
MiR-124-3p attenuates hyperphosphorylation of tau protein-induced apoptosis via caveolin-1-PI3K/akt/GSK3beta pathway in N2a/APP695swe cells. Oncotarget2017;
8: 24314–24326.
74.
LongJMRayBLahiriDK.MicroRNA-339-5p down-regulates protein expression of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of Alzheimer disease subjects. J Biol Chem2014;
289: 5184–5198.
GohSYChaoYXDheenST, et al.
Role of microRNAs in Parkinson's disease. Int J Mol Sci2019;
20: 20191112.
77.
BurgosKMalenicaIMetpallyR, et al.
Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer's and Parkinson's diseases correlate with disease status and features of pathology. PLoS One2014;
9: e94839.
78.
AngelopoulouEPaudelYNPiperiC.miR-124 and Parkinson's disease: a biomarker with therapeutic potential. Pharmacol Res2019;
150: 104515.
79.
EstevesMAbreuRFernandesH, et al.
MicroRNA-124-3p-enriched small extracellular vesicles as a therapeutic approach for Parkinson's disease. Mol Ther2022;
30: 3176–3192.
80.
SuYDengMFXiongW, et al.
MicroRNA-26a/Death-Associated protein kinase 1 signaling induces synucleinopathy and dopaminergic neuron degeneration in Parkinson's disease. Biol Psychiatry2019;
85: 769–781.
81.
MotawiTKAl-KadyRHAbdelraoufSM, et al.
Empagliflozin alleviates endoplasmic reticulum stress and augments autophagy in rotenone-induced Parkinson's disease in rats: targeting the GRP78/PERK/eIF2alpha/CHOP pathway and miR-211-5p. Chem Biol Interact2022;
362: 110002.
82.
GongXHuangMChenL.Mechanism of miR-132-3p promoting neuroinflammation and dopaminergic neurodegeneration in Parkinson's disease. eNeuro2022;
9: 20220125.
83.
ChenCZhangSWeiY, et al.
LncRNA RMST regulates neuronal apoptosis and inflammatory response via sponging miR-150-5p in Parkinson's disease. Neuroimmunomodulation2022;
29: 55–62.
84.
ZhangJSunPZhouC, et al.
Regulatory microRNAs and vascular cognitive impairment and dementia. CNS Neurosci Ther2020;
26: 1207–1218.
85.
SunMK.Potential therapeutics for vascular cognitive impairment and dementia. Curr Neuropharmacol2018;
16: 1036–1044.
86.
PrabhakarPChandraSRChristopherR.Circulating microRNAs as potential biomarkers for the identification of vascular dementia due to cerebral small vessel disease. Age Ageing2017;
46: 861–864.
87.
KangYCZhangLSuY, et al.
MicroRNA-26b regulates the microglial inflammatory response in hypoxia/ischemia and affects the development of vascular cognitive impairment. Front Cell Neurosci2018;
12: 154.
88.
HanXZhouLTuY, et al.
Circulating exo-miR-154-5p regulates vascular dementia through endothelial progenitor cell-mediated angiogenesis. Front Cell Neurosci2022;
16: 881175.
89.
YuBJiangYWangX, et al.
An integrated hypothesis for miR-126 in vascular disease. Med Res Arch2020;
8: 20200525.
90.
TianYZhuPLiuS, et al.
IL-4-polarized BV2 microglia cells promote angiogenesis by secreting exosomes. Adv Clin Exp Med2019;
28: 421–430.
91.
PanYBSunZLFengDF.The role of MicroRNA in traumatic brain injury. Neuroscience2017;
367: 189–199.
92.
AtifHHicksSD.A review of MicroRNA biomarkers in traumatic brain injury. J Exp Neurosci2019;
13: 1179069519832286.
93.
YinZHanZHuT, et al.
Neuron-derived exosomes with high miR-21-5p expression promoted polarization of M1 microglia in culture. Brain Behav Immun2020;
83: 270–282.
94.
LiZXuRZhuX, et al.
MicroRNA-23a-3p improves traumatic brain injury through modulating the neurological apoptosis and inflammation response in mice. Cell Cycle2020;
19: 24–38.
95.
XiaoXJiangYLiangW, et al.
miR-212-5p attenuates ferroptotic neuronal death after traumatic brain injury by targeting Ptgs2. Mol Brain2019;
12: 78.
96.
GeXGuoMHuT, et al.
Increased microglial exosomal miR-124-3p alleviates neurodegeneration and improves cognitive outcome after rmTBI. Mol Ther2020;
28: 503–522.
97.
WuCDuMYuR, et al.
A novel mechanism linking ferroptosis and endoplasmic reticulum stress via the circPtpn14/miR-351-5p/5-LOX signaling in melatonin-mediated treatment of traumatic brain injury. Free Radic Biol Med2022;
178: 271–294.
98.
LongXYaoXJiangQ, et al.
Astrocyte-derived exosomes enriched with miR-873a-5p inhibit neuroinflammation via microglia phenotype modulation after traumatic brain injury. J Neuroinflammation2020;
17: 89.
99.
SumazinPYangXChiuHS, et al.
An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma. Cell2011;
147: 370–381.
100.
WangBCMaJ.Role of MicroRNAs in malignant glioma. Chin Med J (Engl)2015;
128: 1238–1244.
101.
FangLDengZShatsevaT, et al.
MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-beta8. Oncogene2011;
30: 806–821.
102.
WurdingerTTannousBASaydamO, et al.
miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells. Cancer Cell2008;
14: 382–393.
103.
RouigariMDehbashiMGhaediK, et al.
Targetome analysis revealed involvement of MiR-126 in neurotrophin signaling pathway: a possible role in prevention of glioma development. Cell J2018;
20: 150–156.
104.
ChengZXYinWBWangZY.MicroRNA-132 induces temozolomide resistance and promotes the formation of cancer stem cell phenotypes by targeting tumor suppressor candidate 3 in glioblastoma. Int J Mol Med2017;
40: 1307–1314.
105.
LouSJiJChengX, et al.
Oncogenic miR‑132 sustains proliferation and self‑renewal potential by inhibition of polypyrimidine tract‑binding protein 2 in glioblastoma cells. Mol Med Rep2017;
16: 7221–7228.
106.
ChenSWangYNiC, et al.
HLF/miR-132/TTK axis regulates cell proliferation, metastasis and radiosensitivity of glioma cells. Biomed Pharmacother2016;
83: 898–904.
107.
WangYZHanJJFanSQ, et al.
miR-132 weakens proliferation and invasion of glioma cells via the inhibition of Gli1. Eur Rev Med Pharmacol Sci2018;
22: 1971–1978.
108.
ZhangSHanLWeiJ, et al.
Combination treatment with doxorubicin and microRNA-21 inhibitor synergistically augments anticancer activity through upregulation of tumor suppressing genes. Int J Oncol2015;
46: 1589–1600.
109.
LiaoHBaiYQiuS, et al.
MiR-203 downregulation is responsible for chemoresistance in human glioblastoma by promoting epithelial-mesenchymal transition via SNAI2. Oncotarget2015;
6: 8914–8928.
110.
DasguptaIChatterjeeA.Recent advances in miRNA delivery systems. Methods Protoc2021;
4: 20210120.
111.
DoyleLMWangMZ.Overview of extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis. Cells2019;
8: 20190715.
112.
WangJGuoRYangY, et al.
The novel methods for analysis of exosomes released from endothelial cells and endothelial progenitor cells. Stem Cells Int2016;
2016: 2639728.
113.
XiaXWangYHuangY, et al.
Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents. Prog Neurobiol2019;
183: 101694.
114.
GuiYLiuHZhangL, et al.
Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease. Oncotarget2015;
6: 37043–37053.
115.
OhnoSKurodaM.Exosome-Mediated targeted delivery of miRNAs. Methods Mol Biol2016;
1448: 261–270.
116.
WangJChenSZhangW, et al.
Exosomes from miRNA-126-modified endothelial progenitor cells alleviate brain injury and promote functional recovery after stroke. CNS Neurosci Ther2020;
26: 1255–1265.
117.
WangKZhangSWeberJ, et al.
Export of microRNAs and microRNA-protective protein by mammalian cells. Nucleic Acids Res2010;
38: 7248–7259.
118.
FooJBLooiQHHowCW, et al.
Mesenchymal stem cell-derived exosomes and MicroRNAs in cartilage regeneration: biogenesis, efficacy, miRNA enrichment and delivery. Pharmaceuticals (Basel)2021;
14: 20211028.
119.
ShimboKMiyakiSIshitobiH, et al.
Exosome-formed synthetic microRNA-143 is transferred to osteosarcoma cells and inhibits their migration. Biochem Biophys Res Commun2014;
445: 381–387.
120.
AranegaAELozano-VelascoERodriguez-OuteirinoL, et al.
MiRNAs and muscle regeneration: therapeutic targets in Duchenne muscular dystrophy. Int J Mol Sci2021;
22: 20210419.
PusicKMKraigRPPusicAD.IFNgamma-stimulated dendritic cell extracellular vesicles can be nasally administered to the brain and enter oligodendrocytes. PLoS One2021;
16: e0255778.
123.
DengYChenDGaoF, et al.
Exosomes derived from microRNA-138-5p-overexpressing bone marrow-derived mesenchymal stem cells confer neuroprotection to astrocytes following ischemic stroke via inhibition of LCN2. J Biol Eng2019;
13: 71.
124.
YerrapragadaSMSawantHChenS, et al.
The protective effects of miR-210 modified endothelial progenitor cells released exosomes in hypoxia/reoxygenation injured neurons. Exp Neurol2022;
358: 114211.
125.
WangJChenSSawantH, et al.
The miR-210 primed endothelial progenitor cell exosomes alleviate acute ischemic brain injury. Curr Stem Cell Res Ther2023;
19: 1164–1174.
126.
HuangLWuELiaoJ, et al.
Research advances of engineered exosomes as drug delivery carrier. ACS Omega2023;
8: 43374–43387.
127.
QuMLinQHuangL, et al.
Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson's disease. J Control Release2018;
287: 156–166.
128.
TangZHuSWuZ, et al.
Therapeutic effects of engineered exosome-based miR-25 and miR-181a treatment in spinocerebellar ataxia type 3 mice by silencing ATXN3. Mol Med2023;
29: 96.
129.
SepramaniamSTanJRTanKS, et al.
Circulating microRNAs as biomarkers of acute stroke. Int J Mol Sci2014;
15: 1418–1432.
130.
LiKShenLZhengP, et al.
Identification of MicroRNAs as potential biomarkers for detecting ischemic stroke. Genes Genomics2022;
44: 9–17.
131.
NunomuraAPerryG.RNA and oxidative stress in Alzheimer's disease: Focus on microRNAs. Oxid Med Cell Longev2020;
2020: 2638130.
132.
ChengLDoeckeJDSharplesRA, RA, et al.
Prognostic serum miRNA biomarkers associated with Alzheimer's disease shows concordance with neuropsychological and neuroimaging assessment. Mol Psychiatry2015;
20: 1188–1196.
133.
MaWLiYWangC, et al.
Serum miR-221 serves as a biomarker for Parkinson's disease. Cell Biochem Funct2016;
34: 511–515.
134.
DingHHuangZChenM, et al.
Identification of a panel of five serum miRNAs as a biomarker for Parkinson's disease. Parkinsonism Relat Disord2016;
22: 68–73.
135.
YangYLiYYangH, et al.
Circulating microRNAs and long non-coding RNAs as potential diagnostic biomarkers for Parkinson's disease. Front Mol Neurosci2021;
14: 631553.
136.
ZhaiWZhaoMZhangG, et al.
MicroRNA-Based diagnosis and therapeutics for vascular cognitive impairment and dementia. Front Neurol2022;
13: 895316.
137.
DongXZhengDNaoJ.Circulating exosome microRNAs as diagnostic biomarkers of dementia. Front Aging Neurosci2020;
12: 580199.
138.
HeiskanenMDas GuptaSMillsJD, et al.
Discovery and validation of circulating microRNAs as biomarkers for epileptogenesis after experimental traumatic brain Injury-The EPITARGET cohort. Int J Mol Sci2023;
24: 20230201.
139.
HermansenSKKristensenBW.MicroRNA biomarkers in glioblastoma. J Neurooncol2013;
114: 13–23.
140.
AreebZStylliSSKoldejR, et al.
MicroRNA as potential biomarkers in glioblastoma. J Neurooncol2015;
125: 237–248.
141.
ShiYTianTCaiEL, et al.
Corrigendum: miR-124 alleviates ischemic Stroke-Induced neuronal death by targeting DAPK1 in mice. Front Neurosci2021;
15: 745087.
142.
FangMWangJZhangX, et al.
The miR-124 regulates the expression of BACE1/beta-secretase correlated with cell death in Alzheimer's disease. Toxicol Lett2012;
209: 94–105.
143.
WuPHeBLiX, et al.
Roles of microRNA-124 in traumatic brain injury: a comprehensive review. Front Cell Neurosci2023;
17: 1298508.
144.
SilberJLimDAPetritschC, et al.
miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med2008;
6: 14.
