Conference Summary: Is Inhaled Nitric Oxide Therapeutic?

Borland CD , Higenbottam TW . A simultaneous single breath mea-surement of pulmonary diffusing capacity with nitric oxide and car-bon monoxide. Eur Respir J. 1989;2(1):56–63.

Stewart TE , Meade MO , Cook DJ , Granton JT , Hodder RV , Lapin-sky SE , et al. Evaluation of a ventilation strategy to prevent baro-trama in patients at high risk for acute respiratory distress syndrome. The Pressure- and Volume-Limited Ventilation Strategy Group. N Engl J Med. 1998;338(6):355–361.

Dellinger RP , Zimmerman JL , Taylor RW , Straube RC , Hauser DL , Criner GJ , et al. Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome: results of a randomized phase II trial. The Inhaled Nitric Oxide in ARDS Study Group. Crit Care Med. 1998;26(1):15–23.

Amato MBP , Barbas CSV , Medeiros DM , Magaldi RB , Schettino GP , Lorenzi-Filho G , et al. Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med. 1998;338(6):347–354.

Gerlach M , Keh D , Gerlach H. Inhaled nitric oxide for the acute respiratory distress syndrome. Respir Care. 1999;44(2):184–195.

Gerlach H , Rossaint R , Pappert D , Falke KJ . Time-course and dose-response of nitric oxide inhalation for systemic oxygenation and pulmonary hypertension in patients with adult respiratory distress syndrome. Eur J Clin Invest. 1993;23(8):499–502.

Lundin S , Westfelt UN , Stenqvist O , Blomqvist H , Lindh A , Berg-gren L , et al. Response to nitric oxide inhalation in early acute lung injury. Intensive Care Med. 1996;22(8):728–734.

Slutsky AS . Mechanical ventilation (review). American College of Chest Physicians' Consensus Conference. Chest. 1993;104(6):1833–1859.

Murakami S , Bacha EA , Mazmanian GM , Detruit H , Chapelier A , Dartevelle P , Hervé P. Effects of various timings and concentrations of inhaled nitric oxide in lung ischemia-reperfusion. The Paris-Sud University Lung Transplantation Group. Am J Respir Crit Care Med. 1997;156(2 Pt 1):454–458.

Garat C , Jayr C , Eddahibi S , Laffon M , Meignan M , Adnot S. Effects of inhaled nitric oxide on inhibition of endogenous nitric oxide for-mation on hyperoxic lung injury. Am J Respir Crit Care Med. 1997; 155 (6):1957–1964.

McElroy MC , Wiener-Kronish JP , Miyazaki H , Sawa T , Modelska K , Dobbs LG , Pittet JF . Nitric oxide attenuates lung endothelial injury caused by sublethal hyperoxia in rats. Am J Physiol. 1997;272(4 Pt 1):L631–L638.

Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure. The Neonatal Inhaled Nitric Oxide Study Group. N Engl J Med. 1997;336(9):597–604.

Roberts JD Jr , Fineman JR , Morin FC 3rd , Shaul PW , Rimar S , Schreiber MD , et al. Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group. N Engl J Med. 1997;336(9):605–610.

Bocchi EA , Bacal F , Auler JO Jr , Carmone MJ , Bellotti G , Pileggi F. Inhaled nitric oxide leading to pulmonary edema in stable severe heart failure. Am J Cardiol. 1994;74(1):70–72.

Loh E , Stamler JS , Hare JM , Loscalzo J , Colucci WS . Cardiovas-cular effects of inhaled nitric oxide in patients with left ventricular dysfunction. Circulation. 1994;90(6):2780–2785.

Semigran MJ , Cockrill BA , Kacmarek R , Thompson BT , Zapol WM , Dec GW , Fifer MA . Hemodynamic effects of inhaled nitric oxide in heart failure. J Am Coll Cardiol. 1994;24(4):982–988.

Hallman M , Bry K , Turbow R , Waffarn F , Lappalainen U. Pulmo-nary toxicity associated with nitric oxide in term infants with severe respiratory failure. J Pediatr. 1998;132(5):827–829.