Inhaled Nitric Oxide for Acute Respiratory Distress Syndrome

Furchgott RF , Zawadzki JV . The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288(5789):373–376.

Ignarro LJ , Buga GM , Wood KS , Byrns RE , Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 1987;84(24):9265–9269.

Palmer RM , Ferrige AG , Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987;327(6122):524–526.

Palmer RM , Rees DD , Ashton DS , Moncada S. L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation. Biochem Biophys Res Commun 1988;153(3):1251–1256.

Ignarro LJ . Endothelium-derived nitric oxide: actions and properties. FASEB J 1989;3(1):31–36.

Moncada S , Palmer RM , Higgs EA . Nitric oxide: physiology, patho-physiology, and pharmacology. Pharmacol Rev 1991;43(2):109–142.

Gibson QH , Roughton FJW . The kinetics of equilibria of the reac-tions of nitric oxide with sheep hemoglobin. J Physiol 1957;136:507–526.

Oda H , Nogami H , Kusumoto S , Nakajima T , Kurata A , Imai K. Long-term exposure to nitric oxide in mice. J Jpn Soc Air Pollut 1976;11:150–160.

Hugod C. Effect of exposure to 43 ppm nitric oxide and 3.6 ppm nitrogen dioxide on rabbit lung. Int Arch Occup Environ Health 1979;42(3-4):159–167.

Higenbottam T , Pepke-Zaba J , Scott J , Woolman P , Coutts C , Wallwork J. Inhaled "endothelium-derived relaxing factor" (EDRF) in primary hypertension (abstract). Am Rev Respir Dis 1988;137(4 Part 2):107.

Pepke-Zaba J , Higenbottam TW , Dinh-Xuan AT , Stone D , Wallwork J. Inhaled nitric oxide as a cause of selective pulmonary vasodilation in pulmonary hypertension. Lancet 1991;338(8776):1173–1174.

Frostell C , Fratacci MD , Wain JC , Jones R , Zapol WM . Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. Circulation 1991;83(6):2038–2047. Published erratum appears in Circulation 1991;84(5):2212.

Pison U , Lopez FA , Heidelmeyer CF , Rossaint R , Falke KJ . Inhaled nitric oxide selectively reverses hypoxic pulmonary vasoconstriction without impairing pulmonary gas exchange. J Appl Physiol 1993;74(3):1287–1292.

Roberts JD , Polaner DM , Lang P , Zapol WM . Inhaled nitric oxide in persistent pulmonary hypertension of the newborn. Lancet 1992;340(8823):818–819.

Kinsella JP , Neish SR , Shaffer E , Abman SH . Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn. Lancet 1992;340(8823):819–820.

Falke KJ , Rossaint R , Pison U , et al. Inhaled nitric oxide selectively reduces pulmonary hypertension in severe ARDS and improves gas exchange as well as right heart ejection fraction: a case report (abstract). Am Rev Respir Dis 1991;143(4 Part 2):A248.

Rossaint R , Falke KJ , Lopez F , Slama K , Pison U , Zapol WM . Inhaled nitric oxide for the adult respiratory distress syndrome. New Engl J Med 1993;328(6):399–405.

Gerlach H , Pappert D , Lewandowski K , Rossaint R , Falke KJ . Long-term inhalation with evaluated low doses of nitric oxide for selective improvement of oxygenation in patients with adult respiratory dis-tress syndrome. Intensive Care Med 1993;19(8):443–449.

Assreuy J , Cunha FQ , Liew FY , Moncada S. Feedback inhibition of nitric oxide synthase activity by nitric oxide. Br J Pharmacol 1993;108(3):833–837.

Kiff RJ , Moss DW , Moncada S. Effect of nitric oxide gas on the generation of nitric oxide by isolated blood vessels: implications for inhalation therapy. Br J Pharmacol 1994;113(2):496–498.

Villar J , Blazquez MA , Lubillo S , Quintana J , Manzano JL . Pulmonary hypertension in acute respiratory failure. Crit Care Med 1989;17(6):523–526.

Dinh-Xuan AT , Higenbottam TW , Clelland CA , Pepke-Zaba J , Cremona G , Butt AY , et al. Impairment of endothelium-dependent pulmonary-artery relaxation in chronic obstructive lung disease. N Engl J Med 1991;324(22):1539–1547.

Högman M , Frostell C , Arnberg H , Hedenstierna G. Bleeding time prolongation and NO inhalation (letter). Lancet 1993;341(8861):1664–1665.

Högman M , Frostell C , Arnberg H , Sandhagen B , Hedenstierna G. Prolonged bleeding time during nitric oxide inhalation in the rabbit. Acta Physiol Scand 1994;151(1):125–129.

Samama CM , Diaby M , Fellahi JL , Mdhafar A , Eyraud D , Arock M , et al. Inhibition of platelet aggregation by inhaled nitric oxide in patients with acute respiratory distress syndrome. Anesthesiology 1995;83(1):56–65.

Joannidis M , Buratti T , Pechlaner C , Wiedermann C. Inhaled nitric oxide (letter). Lancet 1996;348(9039):1448–1449.

Radomski MW , Vallance P , Whitley G , Foxwell N , Moncada S. Platelet adhesion to human vascular endothelium is modulated by constitutive and cytokine induced nitric oxide. Cardiovasc Res 1993;27(7):1380–1382.

Furlong B , Henderson AH , Lewis MJ , Smith JA . Endothelium-derived relaxing factor inhibits in vitro platelet aggregation. Br J Pharmacol 1987;90(4):687–692.

Radomski MW , Palmer RM , Moncada S. The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide. Br J Pharmacol 1987;92(3):639–646.

Radomski MW , Palmer RM , Moncada S. An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc Natl Acad Sci USA 1990;87(13):5193–5197.

Radomski MW , Palmer RM , Moncada S. Characterization of the L-arginine/nitric oxide pathway in human platelets. Br J Pharmacol 1990;101(2):325–328.

Maurice DH , Haslam RJ . Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of ade-nylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP. Mol Pharmacol 1990;37(5):671–681.

Nguyen BL , Saitoh M , Ware AJ . Interaction of nitric oxide and cGMP with signal transduction in activated platelets. Am J Physiol 1991;261(4 Pt 2):H1043–H1052.

Michelson AD , Benoit SE , Furman MI , Breckwoldt WL , Rohrer MJ , Barnard MR , Loscalzo J. Effects of nitric oxide/EDRF on platelet surface glycoproteins. Am J Physiol 1996;270(5 Pt 2):H1640–H1648.

Gerzer R , Karrenbrock B , Siess W , Heim JM . Direct comparison of the effects of nitroprusside, SIN-1, and various nitrates on platelet aggregation and soluble guanylate cyclase activity. Thromb Res 1988;52(1):11–21.

Keh D , Gerlach M , Kürer I , Seiler S , Kerner T , Falke KJ , Gerlach H. The effects of nitric oxide (NO) on platelet membrane receptor expression during activation with alpha-thrombin. Blood Coag Fibrinolysis 1996;7(6):615–624.

Rossaint R , Gerlach H , Schmidt-Ruhnke H , Pappert D , Lewandowski K , Steudel W , Falke K. Efficacy of inhaled nitric oxide in patients with severe ARDS. Chest 1995;107(4):1107–1115.

Dellinger RP , Zimmerman JL , Taylor RW , Straube RC , Hauser DL , Criner GJ , et al. Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome: results of a randomized phase II trial. Inhaled Nitric Oxide in ARDS Study Group. Crit Care Med 1998;26(1):15–23.

Micheal JR , Barton RG , Saffle JR , Mone M , Markewitz BA , Hillier K , et al. Inhaled nitric oxide versus conventional therapy: effect on oxygenation in ARDS. Am J Respir Crit Care Med 1998;157(5 Pt 1):1372–1380.

Troncy E , Collet JP , Shapiro S , Guimond JG , Blair L , Ducruet T , et al. Inhaled nitric oxide in acute respiratory distress syndrome: a pilot randomized controlled study. Am J Respir Crit Care Med 1998;157(5 Pt 1):1483–1488.

Lundin S , Mang H , Smithies M , Stenquist O , Frostell C , for the European Study Group of Inhaled Nitric Oxide. Inhalation of nitric oxide in acute lung injury: Preliminary results of a European multi-center study (abstract). Intensive Care Med 1997;23(Suppl 1):S2.

Gerlach H , Rossaint R , Pappert D , Falke KJ . Time-course and dose-response of nitric oxide inhalation for systemic oxygenation and pulmonary hypertension in patients with adult respiratory distress syndrome. Eur J Clin Invest 1993;23(8):499–502.

Gustafsson LE , Leone AM , Persson MG , Wiklund NP , Moncada S. Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans. Biochem Biophys Res Commun 1991;181(2):852–857.

Gerlach H , Rossaint R , Pappert D , Knorr M , Falke KJ . Autoinhalation of nitric oxide after endogenous synthesis in nasopharynx. Lancet 1994;343(8896):518–519.

Jia L , Bonaventura J , Stamler JS . S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control. Nature 1996;380(6571):221–226.

Stamler JS , Jia L , Eu JP , McMahon TJ , Demchenko IT , Bonaventura J , Gernert K , Piantadosi CA . Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient. Science 1997;276(5321):2034–2037.