The purpose of this study was to investigate the risk factors for delayed chemotherapy–induced vomiting (DCIV) in pediatric oncology patients. We collected data on pediatric patients from a tertiary care pediatric hospital in an Asian urban center. We analyzed the risk factors for DCIV in patients by univariate analysis and logistic regression. Patients were grouped according to age by the Youden index, and differences in clinical features between the high-risk and low-risk groups were calculated. In the univariate analysis, the number of chemotherapy days, pH, and blood glucose levels were significantly associated with DCIV. In the logistic regression analysis, patient age was an independent risk factor (odds ratio [OR] = 1.013, 95% confidence interval [CI] = 1.005-1.021, P = .002). Children in the high-risk group had a higher grade of vomiting (P < .05). Age is an important risk factor for DCIV in pediatric patients, with older children tending to experience more frequent and more severe vomiting.
NavariRM.Management of chemotherapy-induced nausea and vomiting in pediatric patients. Paediatr Drugs. 2017;19(3):213-222.
2.
CotanchPHockenberryMHerman. Self-hypnosis as antiemetic therapy in children receiving chemotherapy. Oncol Nurs Forum. 1985;12(4):41-46.
3.
ZeltzerLKDolginMJLeBaronSLeBaronC.A randomized, controlled study of behavioral intervention for chemotherapy distress in children with cancer. Pediatrics. 1991;88(1):34-42.
4.
HedströmMHaglundKSkolinIvon EssenL.Distressing events for children and adolescents with cancer: child, parent, and nurse perceptions. J Pediatr Oncol Nurs. 2003;20(3):120-132.
5.
DranitsarisGMolassiotisAClemonsM, et al. The development of a prediction tool to identify cancer patients at high risk for chemotherapy-induced nausea and vomiting. Ann Oncol. 2017;28(6):1260-1267.
6.
ChanAKimH-KHsiehRK, et al. Incidence and predictors of anticipatory nausea and vomiting in Asia Pacific clinical practice: a longitudinal analysis. Support Care Cancer. 2015;23(1):283-291.
7.
MolassiotisAAaproMDicatoM, et al. Evaluation of risk factors predicting chemotherapy-related nausea and vomiting: results from a European prospective observational study. J Pain Symptom Manage. 2014;47(5):839-848.
8.
PirriCKatrisPTrotterJBaylissEBennettRDrummondP.Risk factors at pretreatment predicting treatment-induced nausea and vomiting in Australian cancer patients: a prospective, longitudinal, observational study. Support Care Cancer. 2011;19(10):1549-1563.
9.
WarrDGStreetJCCaridesAD.Evaluation of risk factors predictive of nausea and vomiting with current standard-of-care antiemetic treatment: analysis of phase 3 trial of aprepitant in patients receiving adriamycin-cyclophosphamide-based chemotherapy. Support Care Cancer. 2011;19(6):807-813.
10.
HeskethPJAaproMStreetJCCaridesAD.Evaluation of risk factors predictive of nausea and vomiting with current standard-of-care antiemetic treatment: analysis of two phase III trials of aprepitant in patients receiving cisplatin-based chemotherapy. Support Care Cancer. 2010;18(9):1171-1177.
11.
PatelPRobinsonPDThackrayJ, et al. Guideline for the prevention of acute chemotherapy-induced nausea and vomiting in pediatric cancer patients: a focused update. Pediatr Blood Cancer. 2017;64(10):26542.
12.
Navari Aapro RMM. Antiemetic prophylaxis for chemotherapy-induced nausea and vomiting. N Engl J Med. 2016;374(14):1356-1367.
13.
SheraniFBostonCMbaN.Latest update on prevention of acute chemotherapy-induced nausea and vomiting in pediatric cancer patients. Curr Oncol Rep. 2019;21(10):89.
14.
PatelPRobinsonPDCohenM, et al. Prevention of acute and delayed chemotherapy-induced nausea and vomiting in pediatric cancer patients: a clinical practice guideline. Pediatr Blood Cancer. 2022;69(12):e30001.
15.
FuMRRhodesVXuB.The Chinese translation of the index of nausea, vomiting, and retching. Cancer Nurs. 2002;25(2):134-140.
16.
HaideraliAMendittoLGoodMTeitelbaumAWegnerJ. Impact on daily functioning and indirect/direct costs associated with chemotherapy-induced nausea and vomiting (CINV) in a U.S. Support Care Cancer. 2011;19(6):843-851.
17.
HoldsworthMTRaischDWFrostJ.Acute and delayed nausea and emesis control in pediatric oncology patients. Cancer. 2006;106(4):931-940.
18.
AntonarakisESEvansJLHeardGFNoonanLMPizerBLHainRDW. Prophylaxis of acute chemotherapy-induced nausea and vomiting in children with cancer: what is the evidence. Pediatr Blood Cancer. 2004;43(6):651-658.
19.
RoilaFRoilaFMolassiotisAMaranzanoEClark-SnowRAFeyerP; MASCC/ESMO. Antiemetics in children receiving chemotherapy. Support Care Cancer. 2005;13(2):129-131.
20.
KrisMGHeskethPJHerrstedtJ, et al. Consensus proposals for the prevention of acute and delayed vomiting and nausea following high-emetic-risk chemotherapy. Support Care Cancer. 2005;13(2):85-96.
21.
KamenCTejaniMAChandwaniK, et al. Anticipatory nausea and vomiting due to chemotherapy. Eur J Pharmacol. 2014;722:172-179.
22.
FreedmanJLFaerberJKangTI, et al. Predictors of antiemetic alteration in pediatric acute myeloid leukemia. Pediatr Blood Cancer. 2014;61(10):1798-1805.
23.
HeskethPJKrisMGBaschE, et al. Antiemetics: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol. 2017;35(28):3240-3261.
24.
McFarlandDCJutagirDRMillerAHBreitbartWNelsonCRosenfeldB.Tumor mutation burden and depression in lung cancer: association with inflammation. J Natl Compr Canc Netw. 2020;18(4):434-442.
25.
RussoSCinauseroMGerratanaL, et al. Factors affecting patient’s perception of anticancer treatments side-effects: an observational study. Expert Opin Drug Saf. 2014;13(2):139-150.
26.
BergkvistKWengströmY.Symptom experiences during chemotherapy treatment: with focus on nausea and vomiting. Eur J Oncol Nurs. 2006;10(1):21-29.
27.
KearneyNMcCannLNorrieJ, et al. Evaluation of a mobile phone-based, advanced symptom management system (ASyMS) in the management of chemotherapy-related toxicity. Support Care Cancer. 2009;17(4):437-444.
28.
HeskethPJBohlkeKLymanGH, et al. Antiemetics: American Society of Clinical Oncology focused guideline update. J Clin Oncol. 2016;34(4):381-386.
29.
VerwoerdJvan HoutWJde JongPJ.Disgust- and anxiety-based emotional reasoning in non-clinical fear of vomiting. J Behav Ther Exp Psychiatry. 2016;50:83-89.
30.
TendasAMarchesiFMengarelliA, et al. Prevention of chemotherapy-induced nausea and vomiting after high-dose melphalan and stem cell transplantation: review of the evidence and suggestions. Support Care Cancer. 2019;27(3):793-803.
31.
WatamuraSEDonzellaBKertesDAGunnarMR.Developmental changes in baseline cortisol activity in early childhood: relations with napping and effortful control. Dev Psychobiol. 2004;45(3):125-133.
32.
FredriksonMHurstiTFürstCJ, et al. Nausea in cancer chemotherapy is inversely related to urinary cortisol excretion. Br J Cancer. 1992;65(5):779-780.
