This study investigated whether there is a relationship between atrial fibrillation (AF), mean platelet volume (MPV), and apnea hypopnea index (AHI) in patients who have obstructive sleep apnea syndrome (OSAS). We enrolled patients who had OSAS with either AF or normal sinus rhythm (NSR). We divided 90 patients (aged 50-80 years) into 2 groups: group 1 consisted of 40 patients with OSAS having AF and group 2 of 50 patients with OSAS having NSR. Mean platelet volume was higher in patients with AF than in those with NSR (9.8 ± 0.6 vs 8.4 ± 0.6 fL; P < .001). The MPV and AHI were substantial variables associated with AF (odds ratio [OR] = 2.41; 95% confidence interval [CI], 1.36-5.26; P < .004 and OR = 1.91; 95% CI, 1.26-3.32; P = .02). Elevated MPV value of ≥9.4 fL is associated with AF (70% sensitivity and 63% specificity). More research is needed to establish the clinical relevance of this association.
PartinenMGuilleminaultC. Daytime sleepiness and vascular morbidity at seven-year follow-up in obstructive sleep apnea patients. Chest. 1990;97(1):27–32.
2.
NietoFJYoungTBLindBK. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA. 2000;283(14):1829–1836.
3.
TsioufisCThomopoulosKDimitriadisK. The incremental effect of obstructive sleep apnoea syndrome on arterial stiffness in newly diagnosed essential hypertensive subjects. J Hypertens. 2007;25(1):141–146.
4.
LattimoreJDCelermajerDSWilcoxI. Obstructive sleep apnea and cardiovascular disease. J Am Coll Cardiol. 2003;41(9):1429–1437.
5.
SchaferHKoehlerUEwigSHasperETasciSLüderitzB. Obstructive sleep apnea as a risk marker in coronary artery disease. Cardiology. 1999;92(2):79–84.
6.
JavaheriSParkerTJLimingJD. Sleep apnea in 81 ambulatory male patients with stable heart failure: types and their prevalences, consequences, and presentations. Circulation. 1998;97(21):2154–2159.
7.
GamiASPressmanGCaplesSM. Association of atrial fibrillation and obstructive sleep apnea. Circulation. 2004;110(4):364–367.
8.
ShaharEWhitneyCWRedlineS. Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. Am J Respir Crit Care Med. 2001;163(1):19–25.
9.
ToraldoDMPeveriniFDe BenedettoMDe NuccioF. Obstructive sleep apnea syndrome: blood viscosity, blood coagulation abnormalities, and early atherosclerosis. Lung. 2013;191(1):1–7.
10.
WessendorfTEThilmannAFWangYMSchreiberAKonietzkoNTeschlerH. Fibrinogen levels and obstructive sleep apnea in ischemic stroke. Am J Respir Crit Care Med. 2000;162(6):2039–2042.
11.
SpagnoliLGBonannoESangiorgiGMaurielloA. Role of inflammation in atherosclerosis. J Nucl Med. 2007;48(11):1800–1815.
12.
GasparyanAYAyvazyanLMikhailidisDPKitasGD. Mean platelet volume: a link between thrombosis and inflammation?Curr Pharm Des. 2011;17(1):47–58.
13.
American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2006;29(suppl 1):S43–S48.
14.
National Cholesterol Education Program (NCEP). Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III) final report. Circulation. 2002;106(25):3143–3421.
15.
İnançTKayaMGYarliogluesM. The mean platelet volume in patients with non-dipper hypertension compared to dippers and normotensives. Blood Press. 2010;19(2):81–85.
16.
MuratSNDuranMKalayN. Relation between mean platelet volume and severity of atherosclerosis in patients with acute coronary syndromes. Angiology. 2013;64(2):131–136.
17.
ChoSYJeonYLChoiSKSuhJTLeeHJParkTS. Mean platelet volume in Korean patients with acute ischemic stroke: a gender difference. Platelets. 2013;24(1):75–76.
18.
CobanEYilmazASariR. The effect of weight loss on the mean platelet volume in obese patients. Platelets. 2007;18(3):212–216.
19.
TurfanMErdoganEErtasG. Usefulness of mean platelet volume for predicting stroke risk in atrial fibrillation patients. Blood Coagul Fibrinolysis. 2013;24(1):55–58.
20.
TurgutOZorluAKilicliF. Atrial fibrillation is associated with increased mean platelet volume in patients with type 2 diabetes mellitus. Platelets. 2013;24(6):493–497.
21.
XiaoWHuangYDongJZhangXHuJ. Relationship between platelet volume indices with macrovascular and peripheral neuropathy complications in type 2 diabetic patients. J Diabetes. 2014;6(4):298–303.
22.
NenaEPapanasNSteiropoulosP. Mean platelet volume and platelet distribution width in non-diabetic subjects with obstructive sleep apnoea syndrome: new indices of severity?Platelets. 2012;23(6):447–454.
23.
DastjerdiMSEmamiTNajafianAAminiM. Mean platelet volume measurement, EDTA or citrate?Hematology. 2006;1(5):317–319.
24.
ParkYSchoeneNHarrisW. Mean platelet volume as an indicator of platelet activation: methodological issues. Platelets. 2002;13(5-6):301–306.
25.
GasparyanAY. Platelets in inflammation and thrombosis. Inflamm Allergy Drug Targets. 2010;9(5):319–321.
26.
MartinJFTrowbridgeEASalmonGPlumbJ. The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. Thromb Res. 1983;32(5):443–460.
27.
GilesHSmithREMartinJF. Platelet glycoprotein IIb-IIIa and size are increased in acute myocardial infarction. Eur J Clin Invest. 1994;24(1):69–72.
28.
GamiASCaplesSMSomersVK. Obesity and obstructive sleep apnea. Endocrinol Metab Clin North Am. 2003;32(4):869–894.
29.
WolkRKaraTSomersVK. Sleep-disordered breathing and cardiovascular disease. Circulation. 2003;108(1):9–12.
30.
ColkesenYAcilTAbayliB. Mean platelet volume is elevated during paroxysmal atrial fibrillation: a marker of increased platelet activation?Blood Coagul Fibrinolysis. 2008;19(5):411–414.
31.
SivriNTekinGYaltaKAksoyYSenenKYetkinE. Role of statins on MPV? Statins decrease mean platelet volume irrespective of cholesterol lowering effect. Kardiol Pol. 2013;71(10):1042–1047.
