The concept of non-synaptic diffusion neurotransmission (NDN) is reviewed. Evidence is presented that monoamine neurotransmission is largely by NDN. The role of NDN in pain and sleep is described and its relevance to migraine research is discussed.
Bach-y-RitaPThoughts on the role of volume transmission in normal and abnormal mass sustained functions. In:FuxeKAgnatiLF, editors.Volume transmission in the brain.New York:Raven Press,1991:489–96
2.
Bach-y-RitaPNonsynaptic diffusion neurotransmission (NDN) in the brain.Neurochem Int1993;23:297–318
3.
Bach-y-RitaPPossible role of nonsynaptic diffusion neurotransmission (NDN) and receptor plasticity in shoulder-hand and autonomic dysreflexia syndromes.Scand J Rehab Med1994;26:33–5
4.
BonhoefferTStaigerVAertsenASynaptic plasticity in rat hippocarnpal slice cultures: local “Hebbian” conjunction of pre- and postsynaptic stimulation leads to distributed synaptic enhancement.Proc Natl Acad Sci USA1989;86:8113–7
5.
SchumanEMMadisonDVLocally distributed synaptic potentiation in the hippocampus.Science1994;263:532–6
6.
Bach-y-RitaPPsychopharmacologic drugs: mechanisms of action (Letter).Science1994;264:642–4
7.
ViziESNonsynaptic inhibitory signal transmission between axon terminals: physiological and pharmacological evidence. In:FuxeKAgnatiLF, editors.Volume transmission in the brain: novel mechanisms for neural transmission.New York:Raven Press,1991:89–96
8.
DescarriesLBeaudetAWatkinsKCSerotonin nerve terminals in rat adult neocortex.Brain Res1975;100:563–88
9.
DescarriesLWatkinsKCLapierreYNoradrenergic axon terminals in the cerebral cortex of rat. III. Topometric ultrastructural analysis.Brain Res1977;133:197–222
10.
TennysonVMHeikkilaRMytilineouCCotéLCohenG5-Hydroxydopamine “tagged” neuronal boutons in rabbit neostriatum: interrelationship between vesicles and axonal membrane.Brain Res1974;82:341–6
11.
SoghomonianJJBeaudetADescarriesLUltrastructural relationships of central serotonin neurons. In:OsborneNNHamonM, editors.Neuronal serotonin.Chichester:John Wiley,1988:57–72
12.
ParnavelasJGPapadopoulosCGThe monaminergic innervation of the cerebral cortex is not diffuse and nonspecific.TINS1989;12:314–9
13.
AudetMADoucetGOleskevichSDescarriesLQuantified regional and laminar distribution of the noradrenaline innervation in the anterior half of the adult cerebral cortex.J Comp Neurol1988;274:307–8
14.
AudetMADescarriesLDoucetGQuantified regional and laminar distribution of the serotonin innervation in the anterior half of the adult rat brain.J Chem Neuroanat1989;2:29–44
15.
DescarriesLLemayBDoucetGBergerBRegional and laminar density of the dopamine innervation in adult rat cerebral cortex.Neurosci Left1987;21:807–24
16.
SéguélaPWatkinsKCGeffardMDescarriesLNoradrenaline axon terminals in adult rat neocortex: an immuno-cytochemical analysis in serial thin sections.Neuroscience1990;35:249–64
17.
DescarriesLSéguélaPWatkinsKCNonjunctional relationships on monoamine axon terminals in the cerebral cortex of adult rat. In:FuxeKAgnatiLF, editors.Volume transmission in the brain.New York:Raven Press,1991:53–62
18.
UmbriacoDWatkinsKCDescarriesLCozziriCHartmanBKUltrastructural and morphometric features of the acetyl-choline innervation in adult rat parietal cortex. An electron-microscopic study in serial sections.J Comp Neurol(in press)
19.
NakaiKKasamatsuTTwo types of catecholamine containing terminals in cat visual cortex: an ultrastructural study.Acta Histochem Cytochem1985;15:323–35
20.
MaleyBEEngleMGHumphreysSVascikDAHowesKANewtonBWMonoamine synaptic structure and localization in the central nervous system.Electron Microsc Tech1990;15:20–33
21.
MaleyBEldeRThe ultrastructural localization of serotonin immunoreactivity within the nucleus of the solitary tract of the cat.J Neurosci1982;1499–506
22.
TakagiHMorishimaYMatsuyamaTHayashiHWatanabeTWadaHHistaminergic axons in the neostriatum and cerebral cortex of the cat: a correlated light and electron microscopic immunocytochemical study using histadine decarbonoxylase as a marker.Brain Res1986;364:114–23
23.
PanulaPPirvolaUAuvineSAiraksinenMSHistamine-immunoreactive nerve fibers in the rat brain.Neuroscience1989;28:585–610
24.
WadaHInagakiNYamatodaniAWatanabeTIs the histaminergic neuron system a regulatory center for whole-brain activity?Trends Neurosci1991;14:415–8
25.
AgnatiLFTiengoMFerragitiFBiaginiGBenfenatiFBebedittiCPain, analgesia and stress.Clin J Pain1991;7Suppl 1:S23–37
26.
RajaofetraNRidetJLPoulatPMarlierLSandillonFGeffardMImmunocytochemical mapping of noradrenergic projections to the rat spinal cord with an anti-serum against noradrenalineJ Neurocytol1992;31:481–94
27.
MaxwellDJLeranthCVerhofstadAAJFine structure of serotonin containing axons in the marginal zone of the rat spinal cord.Brain Res1983;266:253–9
28.
MarlierLSandillonSPoulatPRajaofetraNGeffardMPrivatASerotonergic innervation of the dorsal horn of rat spinal cord.J Neurocytol1991;20:310–22
29.
RiderJ-LNajaofetraNTielhacJRGeffardMPrivatAEvidence for non-synaptic serotonergic and noradrenergic innervation of the rat dorsal horn and possible involvement of the neuroglia interactions.Neurosci Left1993;52:143–57
30.
BeaudetASoteloCSynaptic modelling of serotonin axon terminals in rat agranular cerebellum.Brain Res1981;200:305–29
31.
LiuHBrownJLJasminLMaggioJEVignaSRMantyhPWSynaptic relationship between substance P and the substance Preceptor: light and electron microscopic characterization of the mismatch between neuropeptides and their receptors.Pro Natl Acad Sci USA1994;91:1009–113
32.
SteriadeMMcCormickDASejnowskiTJThalamocortical oscillations in the sleeping and aroused brain.Science1993;262:679–65
33.
QuattrochiJJMamelakANMadisonRDMacklisJDHobsonJAMapping neuronal inputs to REM sleep induction sites with carbachol-fluorescent microspheres.Science1989;245:984–6
34.
HobsonJASteriadeMNeuronal basis of behavioral state control. In:MountcastleVM, editor.Handbook of physiology; the nervous system.Bethesda:American Physiological Society,1986:701–823(vol Sec. 1,Vol 4)
35.
DenlingerSPatarcaRHobsonJADifferential enhancement of rapid eye movement sleep signs in the car: a comparison of microinjection of the cholinergic agonist carbachol and the b-adrenergic antagonist propranolol on pontogeniculo-occipital wave clusters.Brain Res1988;473:116–26
36.
Aston-JonesGBloomFEActivity of norepinephrine-con-raining locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle.J Neurosci1981;1:876–86
37.
Aston-JonesGThe locus coeruleus: behavioral functions of locus coeruleus derived from cellular attributes.Physiol Psychol1985;13:118–26
38.
LivingstoneMSHubelDEffects of sleep and arousal on the processing of visual information.Nature1981;291:554–61
