Abstract
Early Evolution and Recovery from Excitotoxic Injury in the Neonatal Rat Brain: A Study Combining Magnetic Resonance Imaging, Electrical Impedance, and Histology
Menno van Lookeren Campagne, Jeroen B. Verheul, Klaas Nicolay and Robert Balázs
[Originally published in J Cereb Blood Flow Metab 1994;14(6):JOll-J023]
The print quality of Fig. 6G in the above article was poor and the figure therefore lacked the necessary detail. The publisher apologizes for this and reprints Fig. 6, in its entirely, with the legend below.
Treatment with NMOA receptor antagonists reduces the hyperintense volume detected with OW MRI. Coronal slices at the level of the posterior striatum (A-C) and the dorsal hippocampus (D-F) monitored by OW and T2W MRI. OW images were obtained before (A, 0) and after (B, E) treatment with antagonists. T2W images were monitored 5 days later (C, F). The antagonists were injected subcutaneously 150 min after intrastiatal NMOA injection. Both MK-801 and O-CPPene clearly reduced the hyperintense area in the OW images (compare Fig 6A and B for MK-801- and Fig. 60 and E for O-CPPene-induced protection). (G) A Nissi-stained coronal section from the brain of the O-Cppene-treated animal 5 days after NMOA injection. The brain was perfusion-fixed directly after acquistion of the T2W image shown in F. The arrowhead in C indicates a hypointense spot, representing gliosis. The arrowheads in F and G indicate areas of necrosis and the widened lateral ventricle. Scale bar = 3 mm.