Current methods for detecting activation foci in positron emission tomography difference images include a low pass filtering step aimed at improving the signal-to-noise ratio. However, we show that detection sensitivity depends both on the activation signal and the filter sizes. Therefore, we propose to improve current detection methods by using a multifiltering strategy that is shown to be more sensitive when various kinds of signals are present in the brain activation images.
AdlerRJ, (1981) The Geometry of Random Fields. New York, Wiley
2.
FoxPTPerlmutterSJARaichleME, (1985) A stereotactic method of anatomical localization for positron emission tomography. J Comput Assist Tomogr9:141–153
3.
FoxPTMintunMAReimanEMRaichleME, (1988) Enhanced detection of focal brain responses using intersubject averaging and change-distribution analysis of substracted PET images. J Cereb Blood Flow Metab8:642–653
4.
FristonKJFrithCDLiddlePFFrackowiakRSJ, (1991) Comparing functional (PET) images: The assessment of significant change. J Cereb Blood Flow Metab11:690–699
5.
KoenderinkJJ, (1984) The structure of images. Biol Cybern50:363–370
6.
MazoyerBMTrebossenRShoukrounCVerreyBSyrotaAVacherJLemassonPMonnetOBouvierALecomteJL, (1990) Physical characteristics of TTV03, a new high spatial resolution time-of-flight positron tomograph. IEEE Trans Nucl Sci37:778–782
7.
MazoyerBMDehaeneSTzourioNFrakVMurayamaNCohenLLevrierOSalamonGSyrotaAMehlerJ, (1993) The cortical representation of speech. Journal of Cognitive Neuroscience5:467–479
8.
MintunMAFoxPTRaichleME, (1989) A highly accurate method of localizing region of neuronal activation in the human brain with positron emission tomography. J Cereb Blood Flow Metab9:96–103
9.
PolineJBMazoyerBM, (1991) Towards an individual analysis of brain activation PET studies: Optimal filtering of difference images. J Cereb Blood Flow Metab11(suppl 2):S564
10.
PolineJBMazoyerBM, (1993) Analysis of individual positron emission tomography activation maps by high signal to noise ratio pixel cluster detection. J Cereb Blood Flow Metab13:425–437
11.
TalairachJTournouxP, (1988) Co-planar Stereotaxic Atlas of the Human Brain. Stuttgart, Georg Thieme Verlag
12.
WorsleyKJEvansACMarrettSNeelinJ, (1992) A three-dimensional statistical analysis for CBF activation studies in human brain. J Cereb Blood Flow Metab12:900–918
