Blood-Tumor Barrier Disruption Controversies

Blasberg R.G. Groothuis D.R. Molnar P. (1990) A review of hyperosmotic blood–brain barrier disruption in seven experimental brain tumor models. In: Pathophysiology of the Blood-Brain Barrier ( Johansson B.B. Owman C. Widner H. , eds), Amsterdam, Elsevier Science Publishers, pp 193–216.

Fishman R.A. (1987) Is there a therapeutic role for osmotic breaching of the blood–brain barrier? (Editorial) Ann Neurol 22:298–299.

Fishman R.A. (1988) Reply. Ann Neurol 24:680.

Groothuis D.R. Blasberg R.G. (1988) Reply. Ann Neurol 24:682–684.

Groothuis D.R. Warnke P.C. Molnar P. Lapin G.D. Mikhael M.A. (1990) Effect of hyperosmotic blood–brain barrier disruption on transcapillary transport in canine brain tumors. J Neurosurg 72:441–149.

Hiesiger E.M. Voorhies R.M. Basler G.A. Lipschutz L.E. Posner J.B. Shapiro W.R. (1986) Opening the blood–brain and blood-tumor barriers in experimental rat brain tumors: The effect of intracarotid hyperosmolar mannitol on capillary permeability and blood flow. Ann Neurol 19:50–59.

Nakagawa H. Groothuis D. Blasberg R.G. (1984) The effect of graded hypertonic intracarotid infusions on drug delivery to experimental RG-2 gliomas. Neurology 34:1571–1581.

Rapoport S.I. (1988) Osmotic opening of the blood–brain barrier. Ann Neurol 24:677–679.

Robinson P.J. Rapoport S.I. (1990) Model for drug uptake by brain tumors: Effects of osmotic treatment and of diffusion in brain. J Cereb Blood Flow Metab 10:153–161.

Shapiro W.R. (1988) Reply. Ann Neurol 24:680–682.

Warnke P.C. Blasberg R.G. Groothuis D.R. (1987) The effect of hyperosmotic blood–brain barrier disruption on blood-to-tissue transport in ENU-induced gliomas. Ann Neurol 22:330–335.