We have revised our methods for calculating regional blood volume, flow, oxygen extraction, and oxygen utilization from positron emission tomography data obtained using 15O-labeled radiotracers. These revisions include radioactive decay explicitly within the model equations instead of requiring all measured activity to be corrected for decay prior to incorporation in the equations. The revised equations yield small but significant differences in the computed values.
FoxP.T.PerlmutterJ.S.RaichleM.E. (1985) A stereotactic method of anatomical localization for positron emission tomography. J Comput Assist Tomogr9:143–153
2.
GrubbR.J.JrRaichleM.E.HigginsC.S.EichlingJ.O. (1978) Measurement of regional blood volume by emission tomography. Ann Neurol4:322–328
3.
HerscovitchP.RaichleM.E. (1985) What is the correct value for the brain–blood partition coefficient for water?J Cereb Blood Flow Metab5:65–69
4.
HerscovitchP.MarkhamJ.RaichleM.E. (1983) Brain blood flow measured with intravenous H215O. I. Theory and error analysis. J Nucl Med24:782–789
5.
HerscovitchP.MintunM.A.RaichleM.E. (1985) Brain oxygen utilization measured with oxygen-15 radiotracers and positron emission tomography: Generation of metabolic images. J Nucl Med26:416–417
6.
MintunM.A.RaichleM.E.MartinW.R.W.HerscovitchP. (1984) Brain oxygen utilization measured with O-15 radiotracers and positron emission tomography. J Nucl Med25:177–187
7.
PerlmutterJ.S.HerscovitchP.PowersW.J.FoxP.T.RaichleM.E. (1985) Standardized mean regional method for calculating global positron emission tomographic measurements. J Cereb Blood Flow Metab5:476–480
8.
RaichleM.E.MartinW.R.W.HerscovitchP.MintunM.A.MarkhamJ. (1983) Brain blood flow measured with intravenous H215O. II. Implementation and validation. J Nucl Med24:790–798
9.
TalairachJ.SziklaG.TournouxP.ProssalentisA.Bordas-FerrerM.CovelloL.IacobM.MempelE. (1967) Atlas d'Anatomie Sterotaxique du Telencephale. Paris, Masson
10.
TorackR.M.AlcalaH.GadoM.BurtonR. (1976) Correlative assay of computerized cranial tomography (CCT), water content and specific gravity in normal and pathological postmortem brain. J Neuropathol Exp Neurol35:385–392
