Cerebral Histamine: Indications for Neuronal and Vascular Regulation

Abboud F.M. Mark A.L. Heistad D.D. Schmid P.G. Barnes R.W. (1976) The venous system. In: Clinical Cardiovascular Physiology, ( Levine H.J. , ed), New York, Grune and Stratton, pp 207–257

Adam H.M. Hye H.K.A. (1966) Concentration of histamine in different parts of the brain and hypophysis of cat and its modification by drugs. Br J Pharmacol Chemother 28:137–152

Andersson R. (1973) Cyclic AMP as a mediator of the relaxing action of papaverine, nitroglycerine, diazoxide and hydralazine in intestinal and vascular smooth muscle. Acta Pharmacol Toxciol 32:321–336

Anthony M. Lance J.W. (1971) Histamine and serotonin in cluster headache. Arch Neurol 25:225–231

Anthony M. Lance J.W. Lord G. (1978) Migrainous neuralgia–Blood histamine levels and clinical response to H1 and H2 receptor blockade. In: Current Concepts in Migraine Research ( Greene R. , ed), New York, Raven Press, pp 149–151

Atack C. Carlsson A. (1972) In vitro release of endogenous histamine, together with noradrenaline and 5-hydroxytryptamine, from slices of mouse cerebral hemisphere. J Pharm Pharmacol 24:990–992

Audigier Y. Virion A. Schwartz J.C. (1976) Stimulation of cerebral histamine H2 receptors by clonidine. Nature 262:307–308

Baca G.M. Palmer G.C. (1978) Presence of hormonally-sensitive adenylate cyclase receptors in capillary-enriched fractions from rat cerebral cortex. Blood Vessels 15:286–298

Baker C.H. (1979) Nonhemodynamic effects of histamine on gracilis muscle capillary permeability. J Pharmacol Exp Ther 211:672–677

Barbin G. Garbarg M. Schwartz J.C. Storm-Mathisen J. (1976) Histamine synthesizing afferents to the hippocampal region. J Neurochem 36:259–263

Baudry M. Martres M.P. Schwartz J.C. (1973) The subcellular localization of histidine decarboxylase in various regions of rat brain. J Neurochem 21:1301–1309

Baudry M. Martres M.P. Schwartz J.C. (1975) H1- and H2-receptors in the histamine-induced accumulation of cyclic AMP in guinea pig brain slices. Nature 253:362–363

Baudry M. Martres M.P. Schwartz J.C. (1976) Modulation in the sensitivity of noradrenergic receptors in the CNS studied by the responsiveness of the cyclic AMP system. Brain Res 116:111–124

Beaven M.A. (1978) Histamine: Its Role in Physiological and Pathological Processes. Monographs in Allergy, Vol 13, ( Dukor P. Kaltos P. Traka Z. Waksman B.H. , eds) Basel, S Karger

Beaven M.A. Shaff R.E. (1979) Inhibition of histamine methylation in vivo by the dimaprit analog, SKF compound 91488. Agents Actions 9:455–460

Bennett C.T. Pert A. (1974) Antidiuresis produced by injections of histamine into the cat supraoptic nucleus. Brain Res 78:151–156

Bevan J.A. Duckles S.P. Lee T.J.F. (1975) Histamine potentiation of nerve and drug induced responses of a rabbit cerebral artery. Circ Res 36:647–653

Bhargava K.P. Dixit K.S. Palit G. (1976) Nature of histamine receptors in the emetic chemoreceptor trigger zone. Br J Pharmacol 57:211–213

Bloom F.E. (1975) The role of cyclic nucleotides in central synaptic function. Rev Physiol Biochem Pharmacol 74:1–103

Bourke R.S. Kimelberg H.K. Nelson L.R. Barron K.D. Auen E.L. Popp A.J. Waldman J.B. (1980) Biology of glial swelling in experimental brain edema. In: Advances in Neurology, Vol 28: Brain Edema ( Cervós-Navarro J. Ferszt R. , eds), New York, Raven Press, pp 99–109

Bourne H.R. Lichtenstein L.M. Melmon K.L. Henney C.S. Weinstein Y. Shearer G.M. (1974) Modulation of inflammation and immunity by cyclic AMP. Science 184:19–28

Bradbury M.W.B. (1979) The Concept of a Blood-Brain Barrier. Chichester, Wiley

Brezenoff H.E. Jenden D.J. (1969) Modification of arterial blood pressure in rats following microinjection of drugs into the posterior hypothalamus. Int J Neuropharmacol 8:593–600

Brezenoff H.E. Lomax P. (1970) Temperature changes following microinjection of histamine into the thermoregulatory centers of the rat. Experientia 26:51–52

Brimble M.J. Wallis D.I. (1973) Histamine H1 and H2 receptors at a ganglionic synapse. Nature 246:156–158

Brody M.J. (1980) Histamine and vascular smooth muscle. In: Vascular Neuroeffector Mechanisms ( Bevan J.A. Godfraind T. Maxwell R.A. Vanhoutte P.M. , eds), New York, Raven Press, pp 82–87

Brody M.J. Knuepfer M. Strait M.R. Shaffer R.A. (1979) Histamine receptors in vascular smooth muscle: Mechanisms of vasodilatation. In: Histamine Receptors ( Yellin T.O. , ed), New York, SP Medical and Scientific Books, pp 115–129

Brown D.D. Tomchick R. Axelrod J. (1959) Distribution and properties of a histamine methylating enzyme. J Biol Chem 234:2948–2950

Brownstein M.J. Saavedra J.M. Palkovits M. Axelrod J. (1974) Histamine content of hypothalamic nuclei of the rat. Brain Res 77:151–156

Burkhard W.P. (1978) Histamine H2 receptor binding with 3H-cimetidine in brain. Eur J Pharmacol 50:449–450

Calcutt C.R. (1976) The role of histamine in the brain. Gen Pharmacol 7:15–25

Carette B. (1978) Responses of preoptic-septal neurons to iontophoretically applied histamine. Brain Res 145:391–395

Carpenter D.O. Baubatz G.L. (1975) H1- and H2-histamine receptors on Aplysia neurons. Nature 254:343–344

Carpi A. Cartoni C. Giardini V. (1972) Segmental effects of histamine, acetylcholine and bradykinin on cerebral vessels. Arch Int Pharm 196:111–112

Casteels R. Suzuki H. (1980) The effect of histamine on the smooth muscle cells of the ear artery of the rabbit. Pfluegers Arch 387:17–25

Chang R.S.L. Snyder S.H. (1980) Histamine H1-receptor binding sites in guinea pig brain membranes: Regulation of agonist interactions by guanine nucleotides and cations. J Neurochem 34:916–922

Chang R.S.L. Tran V.T. Snyder S.H. (1979) Heterogeneity of histamine H1-receptors: Species variations in [3H]mepyramine binding of brain membranes. J Neurochem 32:1653–1663

Charney D.S. Menkes D.B. Heninger G.R. (1981) Receptor sensitivity and the mechanism of action of antidepressant treatment: Implications for the etiology and therapy of depression. Arch Gen Psychiatry 38:1160–1180

Chasin M. Mamrak F. Samaniego S.G. Hess S.M. (1973) Characteristics of the catecholamine and histamine receptor sites mediating accumulation of cyclic adenosine 3′-5′-monophosphate in guinea pig brain. J Neurochem 21:1415–1427

Cohn C.K. Ball G.G. Hirsch J. (1973) Histamine: Effect on self-stimulation. Science 180:757–758

Correa F.M.A. Saavedra J.M. (1981) Increase in histamine concentrations in discrete hypothalamic nuclei of spontaneously hypertensive rats. Brain Res 205:445–451

Cuypers J. Altenkirch H. Bunge S. (1979) Therapy of cluster headache with histamine H1 and H2 receptor antagonists. Eur Neurol 18:345–347

Dale H.H. (1953) Adventures in Physiology. London, Pergamon Press

Dale H.H. Laidlaw P.P. (1910) The physiological action of β-iminazolylethylamine. J Physiol (Lond) 41:318–344

Daly J.W. (1976) The nature of receptors regulating the formation of cyclic AMP in brain tissue. Life Sci 18:1349–1358

Diamond S. Dalessio D.J. Graham J.R. Medina J.L. , (eds) (1976) Vasoactive Substances Relevant to Migraine, Springfield, Thomas

Diana J.N. Fleming B.P. (1979) Some current problems in microvascular research. Microvas Res 18:144–152

Diana J.N. Kaiser R.S. (1970) Pre- and post-capillary resistance during histamine infusion in isolated dog hindlimb. Am J Physiol 218:132–142

Diana J.N. Schwinghamer J. Young S. (1968) Direct effect of histamine on arterial and venous resistance in isolated dog hindlimb. Am J Physiol 214:494–505

Diana J.N. Long S.C. Yao H. (1972) Effect of histamine on equivalent pore radius in capillaries of isolated dog hindlimb. Microvas Res 4:413–437

Diffley D. Tran V.T. Snyder S.H. (1980) Histamine H1-receptors labeled in vivo: Antidepressant and antihistamine interactions. Eur J Pharmacol 64:177–181

Dismukes R.K. Daly J.W. (1974) Norepinephrine-sensitive systems generating adenosine 3′,5′-monophosphate: Increased responses in cerebral cortical slices from reserpine-treated rats. Mol Pharmacol 10:933–940

Dismukes K. Snyder S.H. (1974) Histamine turnover in rat brain. Brain Res 78:467–481

Dismukes K. Kuhar M.J. Snyder S.H. (1974) Brain histamine alterations after hypothalamic isolation. Brain Res 78:144–151

Dogterom J. Greidanus B.V.W. De Wied D. (1976) Histamine as an extremely potent releaser of vasopressin in the rat. Experientia 32:659–660

Donoso A.O. (1978) Induction of prolactin and luteinizing hormone release by histamine in male and female rats and the influence of brain transmitter antagonists. J Endocrinol 76:193–202

Douglas W.W. (1975) Histamine and antihistamines; 5-hydroxytryptamine and antagonists. In: The Pharmacological Basis of Therapeutics, 5th ed ( Goodman L.S. Gilman A. , eds), New York, McMillan, pp 590–629

Duch A.S. Bowers S.W. Nichol C.A. (1978) Elevation of brain histamine levels by diaminopyrimidine inhibitors of histamine N-methyl transferase. Biochem Pharmacol 27:1507–1509

Duch A.S. Edelstein M.P. Nichol C.A. (1980) Inhibition of histamine metabolizing enzymes and elevation of histamine levels in tissues by lipid-soluble anticancer folate antagonists. Mol Pharmacol 18:100–104

Edvinsson L. MacKenzie E.T. (1977) Amine mechanisms in the cerebral circulation. Pharmacol Rev 28:275–348

Edvinsson L. Owman C. (1975) A pharmacological comparison of histamine receptors in isolated extracranial and intracranial arteries in vitro. Neurology 25:271–276

Edvinsson L. Cervós-Navarro J. Larsson L.I. Owman C. Rönnberg A.L. (1977) Regional distribution of mast cells containing histamine, dopamine, or 5-hydroxytryptamine in the mammalian brain. Neurology 27:878–883

Edvinsson L. McCulloch J. Uddman R. (1981) Sympathetic and peptidergic mechanisms in cerebral veins. J Cereb Blood Flow Metabol 1 (Suppl 1):S327–S328

Ehinger B. (1974) Uptake of histamine or histamine metabolites into sympathetic nonadrenergic axons. Acta Physiol Scand 90:218–225

Eidelman B. Karanjia P. Nemoto E. Singh S. (1981) The effects of histamine on cerebral blood flow. J Cereb Blood Flow Metabol 1 (Suppl 1):S365–S366

El-Ackad T.M. Brody M.J. (1974) Fluorescence histochemical localization of non-mast cell histamine. In: Neuropsychopharmacology, Amsterdam, Excerpta Medica, Series 359, pp 551–559

Feldberg W. Paton W.D.M. (1951) Release of histamine from skin and muscle in the cat by opium alkaloids and other histamine liberators. J Physiol (Lond) 114:490–509

Finch L. Hicks P.E. (1977) Involvement of hypothalamic histamine-receptors in the central cardiovascular actions of histamine. Neuropharmacology 16:211–218

Flynn S.B. Owen D.A.A. (1979) Histamine H1- and H2-receptor antagonists reduce histamine-induced increases in vascular permeability and oedema formation in cat skeletal muscle. Agents Actions 9:450–454

Foldes A. Hall R.C. (1979) The effects of histamine on responses of the rabbit ear artery to electrical stimulation and to exogenous noradrenaline. Br J Pharmacol 67:329–335

Földes I. Kelentei B. (1954) Studies on the haemato-encephalic barrier II. The effects of histamine with special reference to the passage of antibiotics. Acta Physiol Acad Sci Hung 5:149–161

Forbes H.S. Wolff H.G. Cobb S. (1929) The cerebral circulation. X. The action of histamine. Am J Physiol 89:266–272

Fox J. Galey F. Wayland H. (1980) Action of histamine on the mesenteric microvasculature. Microvasc Res 19:108–126

Frame M.H. Hedqvist P. (1975) Evidence for prostaglandin mediated prejunctional control of renal sympathetic transmitter release and vascular tone. Br J Pharmacol 54:189–196

Gabbiani G. Badonnel M.C. Majno G. (1970) Intra-arterial injections of histamine, serotonin and bradykinin: A topographic study of vascular leakage. Proc Soc Exp Biol Med 135:447–451

Galeno T.M. Knuepfer M.M. Brody M.J. (1979) Vasodilator response to histamine: Dependence on the site of administration. Eur J Pharmacol 56:257–260

Garbarg M. Krishnamoorthy M.S. Feger J. Schwartz J.C. (1973) Effects of mesencephalic and hypothalamic lesions on histamine levels in rat brain. Brain Res 50:361–367

Garbarg M. Barbin G. Feger J. Schwartz J.C. (1974) Histaminergic pathway in rat brain evidenced by lesions of the medial forebrain bundle. Science 186:833–835

Garbarg M. Barbin G. Bischoff S. Pollard H. Schwartz J.C. (1976) Dual localization of histamine in an ascending pathway and in non-neuronal cells evidenced by lesions in the lateral hypothalamic area. Brain Res 106:333–348

Garbarg M. Barbin G. Palacios J.M. Schwartz J.C. (1978) Effects of kainic acid on histaminergic systems in guinea pig hippocampus. Brain Res 150:638–641

Garbarg M. Barbin G. Llorens C. Palacios J.M. Pollard H. Schwartz J.C. (1980a) Recent developments in brain histamine research: Pathways and receptors. In: Neurotransmitters, Receptors and Drug Action ( Essman W.B. , ed), New York, SP Medical and Scientific Books, pp 179–202

Garbarg M. Barbin G. Rodergas E. Schwartz J.C. (1980b) Inhibition of histamine synthesis in brain by α-fluoromethylhistidine, a new irreversible inhibitor: In vitro and in vivo studies. J Neurochem 35:1045–1052

Geller H.M. (1979) Are histamine H2-receptor depressions of nueronal activity in tissue cultures from rat hypothalamus mediated through cyclic adenosine monophosphate? Neurosci Letters 14:49–53

Geller H.M. (1981) Histamine actions on activity of cultured hypothalamic neurons: Evidence for mediation by H1- and H2-histamine receptors. Dev Brain Res 1:89–101

Gerald M.C. Maickel R.P. (1972) Studies on the possible role of brain histamine in behaviour. Br J Pharmacol 44:462–471

Goth A. Johnson A.R. (1975) Current concepts on the secretory function of mast cells. Life Sci 16:1201–1214

Green J.P. Maayani S. (1977) Tricyclic antidepressant drugs block histamine H2 receptors in brain. Nature 269:163–165

Green J.P. Johnson C.L. Weinstein H. (1978) Histamine as a neurotransmitter. In: Psychopharmacology: A Generation of Progress ( Lipton M.A. DiMascio A. Killam K.F. , eds), New York, Raven Press, pp 319–332

Green J.P. Johnson C.L. Weinstein H. (1979) Histamine activation of adenylate cyclase in brain: An H2-receptor and its blockade by LSD. In: Histamine Receptors ( Yellin T.O. , ed), New York, SP Medical Scientific Books, pp 185–210

Green J.P. Maayani S. Weinstein H. Hough L.B. (1980) Histamine and psychotropic drugs. Pharmacol Bull 16:36–38

Green M.D. Cox B. Lomax P. (1975) Histamine H1- and H2-receptors in the central thermoregulatory pathways of the rat. J Neurosci Res 1:353–359

Gross P.M. (1981) Hypothesis: Histamine H1 and H2 receptors are spatially and differentially distributed in the cerebral circulation. J Cereb Blood Flow Metabol 1:441–446

Gross P.M. Heistad D.D. Strait M.R. Marcus M.L. Brody M.J. (1979) Cerebral vascular responses to physiological stimulation of sympathetic pathways in cats. Circ Res 44:288–294

Gross P.M. Teasdale G.M. Angerson W.J. Harper A.M. (1980) Characteristics of increased cerebrovascular permeability resulting from carotid arterial infusion of histamine. III International Migraine Symposium, London, The Migraine Trust, pp 5–7

Gross P.M. Harper A.M. Graham D.I. (1981a) Cerebral blood flow in rats during physiological and humoral stimuli. Stroke 12:345–352

Gross P.M. Harper A.M. Teasdale G.M. (1981b) Cerebral circulation and histamine 1. Participation of vascular H1- and H2-receptors in vasodilatatory responses to carotid arterial infusion. J Cereb Blood Flow Metabol 1:97–108

Gross P.M. Harper A.M. Teasdale G.M. (1981c) Cerebral circulation and histamine 2. Responses of pial veins and arterioles to receptor agonists. J Cereb Blood Flow Metabol 1:219–225

Gross P.M. Harper A.M. Teasdale G.M. (1981d) Impromidine, a potent dilator of cat pial arterioles. Eur J Pharmacol 73:225–227

Gross P.M. Harper A.M. Teasdale G.M. (1981e) Inhibition by histamine of noradrenergic constriction of cat pial vessels: Pre- and post-junctional sites of interaction. Symposium on Cerebral Blood Flow: Effects of Nerves and Neurotransmitters, Iowa City. Abstract

Gross P.M. Teasdale G.M. Angerson W.J. Harper A.M. (1981f) H2-receptors mediate increases in permeability of the blood-brain barrier during arterial histamine infusion. Brain Res 210:436–440

Gross P.M. Harper A.M. Teasdale G.M. (1982a) Regional effect of mepyramine on cerebral glucose utilization in conscious rats. Eur J Pharmacol, in press

Gross P.M. Teasdale G.M. Graham D.I. Angerson W.J. Harper A.M. (1982b) Histamine increases blood-brain transport in rats. Am J Physiol, in press

Haas H.L. (1974) Histamine: Action on single hypothalamic neurones. Brain Res 76:363–366

Haas H.L. Wolf P. (1977) Central actions of histamine: Microelectrophoretic studies. Brain Res 122:269–279

Haas H.L. Anderson E.G. Hösli L. (1973) Histamine and metabolites: Their effects and interactions with convulsants on brain stem neurones. Brain Res 51:269–278

Haas H.L. Wolf P. Nussbaumer J.C. (1975) Histamine: Action on supraoptic and other hypothalamic neurons of the cat. Brain Res 88:166–169

Haddy F.J. (1960) Effect of histamine on small and large vessel pressures in the dog foreleg. Am J Physiol 198:161–168

Haddy F.J. Scott J.B. Grega G.J. (1972) Effects of histamine on lymph protein concentration and flow in the dog forelimb. Am J Physiol 223:1172–1177

Haeusler G. (1973) Activation of the central pathway of the baroreceptor reflex, a possible mechanism of the hypotensive action of clonidine. Naunyn Schmiedebergs Arch Pharmacol 278:231–246

Harper A.M. MacKenzie E.T. McCulloch J. Pickard J.D. (1977) Migraine and the blood-brain barrier. Lancet i (May 14):1034–1036

Head R.J. Hjelle J.T. Jarrott B. Berkowitz B. Cardinale G. Spector S. (1980) Isolated brain microvessels: Preparation, morphology, histamine and catecholamine contents. Blood Vessels 17:173–186

Hebel R. Stromberg M.W. (1976) Anatomy of the Laboratory Rat, Baltimore, Williams & Wilkins

Hegstrand L.R. Kanof P.D. Greengard P. (1976) Histamine-sensitive adenylate cyclase in mammalian brain. Nature 260:163–165

Heistad D.D. (1980) Protection of cerebral vessels by sympathetic nerves. Physiologist 23:44–49

Heistad D.D. Marcus M.L. (1978) Evidence that neural mechanisms do not have important effects on cerebral blood flow. Circ Res 42:295–302

Heistad D.D. Marcus M.L. Said S.I. Gross P.M. (1980) Effect of acetylcholine and vasoactive intestinal peptide on cerebral blood flow. Am J Physiol 239:H73–H80

Heitz D.C. Brody M.J. (1975) Possible mechanism of histamine release during active vasodilatation. Am J Physiol 228:1351–1357

Hertz M.M. Bolwig T.G. (1976) Blood-brain barrier studies in the rat: An indicator dilution technique with tracer sodium as an internal standard for estimation of extracranial contamination. Brain Res 107:333–343

Hoffman W.E. Schmid P.G. (1978) Cardiovascular and antidiuretic effects of central histamine. Life Sci 22:1709–1714

Hollister L.E. (1978) Tricyclic antidepressants. N Engl J Med 299:1106–1109

Horton B.T. (1941) The use of histamine in the treatment of specific types of headaches. JAMA 116:377–383

Hurley J.V. (1972) Acute Inflammation. Edinburgh, Churchill Livingstone

Hurst E.W. Davies O.L. (1950) Studies on the blood-brain barrier. II. Attempts to influence the passage of substances into the brain. Br J Pharmacol 5:147–163

Ibrahim M.Z.M. (1974) The mast cells of the mammalian central nervous system I. Morphology, distribution and histochemistry. J Neurol Sci 21:431–478

Jarrott B. Hjelle J.T. Spector S. (1979) Association of histamine with cerebral microvessels in regions of bovine brain. Brain Res 168:323–330

Jennett B. Miller J.D. Harper A.M. (1976) Anatomy of the collateral cerebral circulation in man and animals. In: Effect of Carotid Artery Surgery on Cerebral Blood Flow, Amsterdam, Excerpta Medica, pp 21–39

Joó F. (1979) Significance of adenylate cyclase in the regulation of the permeability of brain capillaries. In: Pathophysiology of Cerebral Energy Metabolism ( Mrsulja B.B. Rakie M. Klatzo I. Spatz M. , eds), New York, Plenum Press, pp 211–237

Joris I. Majno G. Ryan G.B. (1972) Endothelial contraction in vivo: A study of the rat mesentery. Virchows Arch (Cell Pathol) 12:73–83

Kakiuchi S. Rall T.W. (1968) The influence of chemical agents on the accumulation of adenosine 3′-5′-phosphate in slices of rabbit cerebellum. Mol Pharmacol 9:711–717

Kanof P.D. Greengard P. (1978) Brain histamine receptors as targets for antidepressant drugs. Nature 272:329–333

Karnushina I.L. Palacios J.M. Barbin G. Dux E. Joó F. Schwartz J.C. (1980) Studies on a capillary-rich fraction isolated from brain: Histaminic components and characterisation of the histamine receptors linked to adenylate cyclase. J Neurochem 34:1201–1208

Karobath M.E. (1975) Tricyclic antidepressive drugs and dopamine-sensitive adenylate cyclase from rat brain striatum. Eur J Pharmacol 30:159–163

Karppanen H. Paakkari I. Paakkari P. Huotari R. Orma A-L , (1976) Possible involvement of central histamine H2-receptors in the hypotensive effect of clonidine. Nature 259:587–588

Karppanen H. Paakkari I. Paakkari P. (1977) Further evidence for central histamine H2-receptor involvement in the hypotensive effect of clonidine in the rat. Eur J Pharmacol 42:299–302

Karppanen H. Paakkari I. Paakkari P. (1979) Studies on the nature of cerebral receptors mediating the hypotensive effect of clonidine in rats. In: Histamine Receptors ( Yellin T.O. , ed), New York, SP Medical and Scientific Books, pp 255–269

Kataoka K. De Robertis E. (1967) Histamine in isolated small nerve endings and synaptic vesicles of rat brain cortex. J Pharmacol Exp Ther 156:114–125

Kennedy C. Suda S. Smith C.B. Miyaoka M. Ito M. Sokoloff L. (1981) Changes in protein synthesis underlying functional plasticity in immature monkey visual system. Proc Natl Acad Sci USA 78:3950–3953

Klein M.C. Gertner S.B. (1981) Evidence for a role of endogenous histamine in central cardiovascular regulation: Inhibition of histamine-N-methyltransferase by SKF 91488. J Pharmacol Exp Ther 216:315–320

Kodama T. Matsukado Y. Shimazu H. (1973) The cyclic AMP system of human brain. Brain Res 50:135–146

Kollonitsch J. Patchett A.A. Marburg S. Maycock A.L. Perkins L.M. Doldouras G.A. Duggan D.E. Aster S.D. (1978) Selective inhibitors of biosynthesis of aminergic neurotransmitters. Nature 274:906–908

Krabbe A.A. Olesen J. (1980) Headache provocation by continuous intravenous infusion of histamine. Clinical results and receptor mechanisms. Pain 8:253–259

Kuhar M.J. Taylor K.M. Snyder S.H. (1971) The subcellular localization of histamine and histamine methyltransferase in rat brain. J Neurochem 18:1515–1527

Kuschinsky W. Wahl M. (1978) Local chemical and neurogenic regulation of cerebral vascular resistance. Physiol Rev 58:656–689

Kwiatkowski H. (1943) Histamine in nervous tissue. J Physiol (Lond) 102:32–41

Leibowitz S.F. (1973) Histamine: A stimulatory effect on drinking behavior in the rat. Brain Res 63:440–444

Leibowitz S.F. (1979) Histamine: Modification of behavioral and physiological components of body fluid homeostasis. In: Histamine Receptors ( Yellin T.O. , ed), New York, SP Medical and Scientific Books, pp 219–253

Levine R.J. Sato T.L. Sjverdsma A. (1965) Inhibition of histamine synthesis in the rat by α-hydrazino analog of histidine and 4-bromo-3-hydroxybenzyloxyamine. Biochem Pharmacol 14:139–149

Libertun C. McCann S.M. (1976) The possible role of histamine in the control of prolactin and gonadotropin release. Neuroendocrinology 20:110–120

Lichtenstein L.M. Gillespie E. (1975) The effects of the H1 and H2 antihistamines on “allergic” histamine release and its inhibition by histamine. J Pharmacol Exp Ther 192:441–450

Lidbrink P. Jonsson G. Fuxe K. , (1971) The effect of imipramine-like drugs and antihistamine drugs on uptake mechanisms in the central noradrenaline and 5-hydroxytryptamine neurons. Neuropharmacology 10:521–536

Lokhandwala M.F. (1978) Inhibition of sympathetic nervous system by histamine: Studies with H1- and H2-receptor antagonists. J Pharmacol Exp Ther 206:115–122

Majno G. Shea S.M. Leventhal M. (1969) Endothelial contraction induced by histamine-type mediators. J Cell Biol 42:647–672

Makman M.H. Ahn H.S. Thal L.J. Sharpless N.S. Dvorkin B. Horowitz S.G. Rosenfeld M. (1979) Aging and monoamine receptors in brain. Federation Proc 38:1922–1926

McCulloch J. Edvinsson L. (1980) Cerebral circulatory and metabolic effects of vasoactive intestinal polypeptide. Am J Physiol 238:H449–H456

McGrath M.A. Shepherd J.T. (1976) Inhibition of adrenergic neurotransmission in canine vascular smooth muscle by histamine: Mediation by H2-receptors. Circ Res 39:566–573

McNamee J.E. Grodins F.S. (1975) Effect of histamine on microvasculature of isolated dog gracilis muscle. Am J Physiol 229:119–125

McNeill J.H. (1980) Histamine receptors and cyclic AMP. Can J Physiol Pharmacol 58:1023–1030

Monnier M. Sauer R. Hatt A.M. (1970) The activating effect of histamine on the central nervous system. Int Rev Neurobiol 12:265–305

Morris J.B. Beck A.T. (1974) The efficacy of antidepressant drugs. Arch Gen Psychiatry 30:667–674

Muravchick S. Bergofsky E.H. (1976) Adrenergic receptors and vascular resistance in cerebral circulation of the cat. J Appl Physiol 40:797–804

Nahorski S.R. Rogers K.J. Smith B.M. (1974) Histamine H2 receptors and cyclic AMP in brain. Life Sci 15:1887–1894

Nanda R.N. Arthur G.P. Johnson R.H. Lambie D.G. (1980) Cimetidine in the prophylaxis of migraine. Acta Neurol Scand 62:90–95

Nathanson J.A. Greengard P. (1977) “Second messengers” in the brain. Sci Am 237:109–119

Oldendorf W.H. (1971) Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. Am J Physiol 221:1629–1639

Orr E. Quay W.B. (1975) Hypothalamic 24-hour rhythm in histamine, histidine decarboxylase and histamine N-methyltransferase. Endocrinology 96:941–945

Owen D.A.A. (1977) Histamine receptors in the cardiovascular system. Gen Pharmacol 8:141–156

Palacios J.M. Garbarg M. Barbin G. Schwartz J.C. (1978) Pharmacological characterization of histamine receptors mediating the stimulation of cyclic AMP accumulation in slices from guinea pig hippocampus. Mol Pharmacol 14:971–982

Palacios J.M. Wamsley J.K. Kuhar M.J. (1981) The distribution of histamine H1-receptors in the rat brain: An autoradiographic study. Neuroscience 6:15–37

Palmer G.C. Schmidt M.J. Robinson G.A. (1972) Development and characteristics of the histamine-induced accumulation of cyclic AMP in the rabbit cerebral cortex. J Neurochem 19:2251–2256

Peroutka S.J. Snyder S.H. (1981) [3H]Mianserin: Differential labeling of serotonin2 and histamine1 receptors in rat brain. J Pharmacol Exp Ther 216:142–148

Peroutka S.J. Moskowitz M.A. Reinhard J.F. Jr Snyder S.H. (1980) Neurotransmitter receptor binding in bovine cerebral microvessels. Science 208:610–612

Phillis J.W. Tebecis A.K. York D.H. (1968) Histamine and some antihistamines: Their actions on cerebral cortical neurones. Br J Pharmacol Chemother 33:426–440

Plaut M. (1979) Histamine, H1 and H2 antihistamines and immediate hypersensitivity reactions. J Allergy Clin Immunol 63:371–375

Plaut M. Lichtenstein L.M. (1979) Modulation of inflammation by histamine receptor-bearing cells. In: Histamine Receptors ( Yellin T.O. , ed), New York, SP Medical and Scientific Books, pp 351–360

Pollard H. Bischoff S. Schwartz J.C. (1973) Decreased histamine synthesis in the rat brain by hypnotics and anaesthetics. J Pharm Pharmacol 25:920–922

Pollard H. Bischoff S. Schwartz J.C. (1974) Turnover of histamine in rat brain and its decrease under barbiturate anaesthesia. J Pharmacol Exp Ther 190:89–99

Portaleone P. Pagnini O. Crispino A. Genazzani E. (1978) Histamine-sensitive adenylate cyclase in hypothalamus of rat brain: H1 and H2 receptors. J Neurochem 31:1371–1374

Powell J.R. (1979) Effects of histamine on vascular sympathetic neuroeffector transmission. J Pharmacol Exp Ther 208:360–365

Powell J.R. Brody M.J. (1976a) Identification and specific blockade of two receptors for histamine in the cardiovascular system. J Pharmacol Exp Ther 196:1–14

Powell J.R. Brody M.J. (1976b) Participation of H1 and H2 histamine receptors in physiological vasodilator responses. Am J Physiol 231:1002–1009

Purves M.J. (1978) Do vasomotor nerves significantly regulate cerebral blood flow. Circ Res 43:485–493

Quach T.T. Duchemin A.M. Rose C. Schwartz J.C. (1979) In vivo occupation of cerebral histamine H1-receptors evaluated with 3H-mepyramine may predict sedative properties of psychotropic drugs. Eur J Pharmacol 60:391–392

Quach T.T. Duchemin A.M. Rose C. Schwartz J.C. (1980) 3H-Glycogen hydrolysis elicited by histamine in mouse brain slices: Selective involvement of H1 receptors. Mol Pharmacol 17:301–308

Raper A.J. Kontos H.A. Wei E.P. Patterson J.L. Jr (1972) Unresponsiveness of pial precapillary vessels to catecholamines and sympathetic nerve stimulation. Circ Res 31:257–266

Rapoport S.I. (1976) Blood-Brain Barrier in Physiology and Medicine, New York, Raven Press

Rapoport S.I. Fredericks W.R. Ohno K. Pettigrew K.D. (1980) Quantitative aspects of reversible osmotic opening of the blood-brain barrier. Am J Physiol 238:R421–R431

Reinhardt D. Ritter E. Butzheinen R. Schumann H.J. (1979) Relationship between histamine-induced changes of cyclic AMP and mechanical activity on smooth muscle preparations of the guinea pig ileum and the rabbit mesenteric artery. Agents Actions 9:155–162

Renaud L.P. (1976) Histamine microiontophoresis on identified hypothalamic neurones: 3 patterns of response in the ventromedial nucleus of the rat. Brain Res 115:339–344

Renkin E.M. Carter R.D. Joyner W.L. (1974) Mechanisms of the sustained action of histamine and bradykinin on transport of large molecules across capillary walls in the dog paw. Microvasc Res 7:49–60

Richelson E. (1978) Histamine H1-receptor-mediated guanosine 3′-5′-monophosphate formation by cultured mouse neuroblastoma cells. Science 211:69–71

Richelson E. (1979) Tricyclic antidepressants and histamine H1 receptors. Mayo Clin Proc 54:669–674

Robertson I. Greaves M.W. (1978) Responses of human skin blood vessels to synthetic histamine analogues. Br J Clin Pharmacol 5:319–322

Rosenblum W.I. (1976) Pial arteriolar responses in the mouse brain revisited. Stroke 7:283–287

Ross S.B. Renyi A.L. (1969) Inhibition of the uptake of tritiated 5-hydroxytryptamine in brain tissue. Eur J Pharmacol 7:270–277

Rossi G.V. (1979) Histamine–A review of physiology and pharmacology. In: Histamine Receptors ( Yellin T.O. , ed), New York, SP Medical and Scientific Books, pp 1–22

Roy C.W. Sherrington C.S. (1890) On the regulation of the blood supply of the brain. J Physiol (Lond) 11:85–108

Rudolph C. Richards G.F. Kaplan S. Ganong W.F. (1979) Effect of intraventricular histamine on hormone secretion in dogs. Neuroendocrinology 29:169–177

Ryan M.J. Brody M.J. (1970) Distribution of histamine in the canine autonomic nervous system. J Pharmacol Exp Ther 174:123–132

Ryan M.J. Brody M.J. (1972) Neurogenic and vascular stores of histamine in the dog. J Pharmacol Exp Ther 181:83–91

Ryan R.E. Sr Ryan R.E. Jr (1978) Headache and Head Pain: Diagnosis and Treatment, St. Louis, CV Mosby

Sastry B.S.R. Phillis J.W. (1976) Evidence for an ascending inhibitory histaminergic pathway to the cerebral cortex. Can J Physiol Pharmacol 54:782–786

Sastry B.S.R. Phillis J.W. (1977) Evidence that clonidine can activate histamine H2-receptors in rat cerebral cortex. Neuropharmacology 16:223–225

Saxena P.R. (1975) The significance of histamine H1 and H2 receptors on the carotid vascular bed in the dog. Neurology 25:681–687

Schayer R.W. Reilly M.A. (1973) Formation and fate of histamine in rat and mouse brain. J Pharmacol Exp Ther 184:33–40

Schwartz J.C. (1977) Histaminergic mechanisms in brain. Ann Rev Pharmacol Toxicol 17:325–339

Schwartz J.C. (1979) Histamine receptors in brain. Life Sci 25:895–911

Schwartz J.C. Lampart C. Rose C. (1970) Properties and regional distribution of histidine decarboxylase in rat brain. J Neurochem 17:1527–1534

Schwartz J.C. Lampart C. Rose C. (1972) Histamine formation in rat brain in vivo: Effects of histidine loads. J Neurochem 19:801–810

Schwartz J.C. Barbin G. Garbarg M. Pollard H. Rose C. Verdiere M. (1976) Neurochemical evidence for histamine acting as a transmitter in mammalian brain. In: Advances in Biochemical Psychopharmacology, Vol 15, New York, Raven Press, pp 111–126

Schwartz J.C. Palacios J.M. Barbin G. Quach T.T. Garbarg M. Haas H.L. Wolf P. (1979) Histamine receptors in mammalian brain: Characteristics and modifications studied electrophysiologically and biochemically. In: Histamine Receptors ( Yellin T.O. , ed), New York, SP Medical and Scientific Books, pp 161–183

Schwartz J.C. Barbin G. Duchemin A.M. Garbarg M. Palacios J.M. Quach T.T. Rose C. (1980a) Histamine receptors in the brain: Characterization by binding studies and biochemical effects. In: Receptors for Neurotransmitters and Peptide Hormones ( Pepen G. Kuhar M.J. Enna S.J. , eds), New York, Raven Press, pp 169–182

Schwartz J.C. Pollard H. Quach T.T. (1980b) Histamine as a neurotransmitter in mammalian brain: Neurochemical evidence. J Neurochem 35:26–33

Singh V.K. McGeer E.G. (1979) Binding of [3H]histamine to receptor sites in rat brain. Exp Neurol 66:413–418

Snyder S.H. Bennett J.P. (1976) Neurotransmitter receptors in the brain: Biochemical identification. Annu Rev Physiol 38:153–175

Snyder S.H. Taylor K.M. (1972) Histamine in the brain: A neurotransmitter? In: Perspectives in Neuropharmacology: A Tribute to Julius Axelrod ( Snyder S.H. , ed), New York, Oxford Univ Press, pp 43–73

Snyder S.H. Yamamura H.I. (1977) Antidepressants and the muscarinic acetylcholine receptor. Arch Gen Psychiatry 34:236–239

Snyder S.H. Axelrod J. Bauer H. (1964) The fate of ¹⁴C-histamine in animal tissues. J Pharmacol Exp Ther 144:373–379

Snyder S.H. Brown B. Kuhar M.J. (1974) The subsynaptosomal localization of histamine, histidine decarboxylase and histamine methyltransferase in rat hypothalamus. J Neurochem 23:37–46

Sokoloff L. (1959) The action of drugs on the cerebral circulation. Pharmacol Rev 11:1–85

Sokoloff L. (1981a) Relationships among local functional activity, energy metabolism, and blood flow in the central nervous system. Fed Proc 40:2311–2316

Sokoloff L. (1981b) Localization of functional activity in the central nervous system by measurement of glucose utilization with radioactive deoxyglucose. J Cereb Blood Flow Metabol 1:7–36

Sokoloff L. Reivich M. Kennedy C. Des Rosiers M.H. Patlak C.S. Pettigrew O. Sakurada O. Shinohara M. (1977) TThe [¹⁴C]deoxyglucose method for the measurement of local cerebral glucose utilization: Theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem 28:897–916

Spector W.G. Willoughby D.A. (1963) The inflammatory response. Bacteriol Rev 27:117–154

Spira P.J. Mylecharane E.F. Misbach J. Duckworth J.W. Lance J.W. (1978) Internal and external carotid vascular responses to vasoactive agents in the monkey. Neurology 28:162–173

Starke K. Taube H.D. Borowski E. (1977) Presynaptic receptor systems in catecholaminergic transmission. Biochem Pharmacol 26:259–268

Study R.E. Greengard P. (1978) Regulation by histamine of cyclic nucleotide levels in sympathetic ganglia. J Pharmacol Exp Ther 207:767–778

Subramanian N. Muelder A.H. (1976) Potassium-induced release of tritiated histamine from rat brain tissue slices. Eur J Pharmacol 35:203–206

Subramanian N. Whitmore W.L. Seidler F.J. Slotkin T.A. (1981) TOntogeny of histaminergic neurotransmission in the rat brain: Concomitant development of neuronal histamine, H1 receptors, and an H1 receptor-mediated stimulation of phospholipid turnover. J Neurochem 36:1137–1141

Taylor J.E. Richelson E. (1980) THigh affinity binding of tricyclic antidepressants to histamine H1-receptors: Fact and artifact. Eur J Pharmacol 67:41–46

Taylor K.M. Snyder S.H. (1971) Brain histamine: Rapid apparent turnover altered by restraint and cold stress. Science 172:1037–1039

Taylor K.M. Snyder S.H. (1972a) Dynamics of the regulation of histamine levels in mouse brain. J Neurochem 19:341–354

Taylor K.M. Snyder S.H. (1972b) Isotopic microassay of histamine, histidine, histidine decarboxylase and histamine methyl transferase in brain tissue. J Neurochem 19:1343–1358

Taylor K.M. Snyder S.H. (1973) The release of histamine from tissue slices of rat hypothalamus. J Neurochem 21:1215–1223

Taylor K.M. Gfeller E. Snyder S.H. (1972) Regional localization of histamine and histidine in the brain of the Rhesus monkey. Brain Res 41:171–179

Tindall G.T. Greenfield J.C. (1973) The effects of intra-arterial histamine on blood flow in the internal and external carotid artery of man. Stroke 4:46–49

Tran V.T. Chang R.S.L. Snyder S.H. (1978) THistamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine. Proc Nat Acad Sci USA 75:6290–6294

Tran V.T. Freeman A.D. Chang R.S.L. Snyder S.H. (1980) TOntogenetic development of histamine H1-receptor binding in rat brain. J Neurochem 34:1609–1613

Tuomisto L. Eriksson L. Fyhrquist F. (1980) Vasopressin release by histamine in the conscious goat. Eur J Pharmacol 63:15–24

U'Prichard D.C. Greenberg D.A. Sheehan P.P. Snyder S.H. (1978) Tricyclic antidepressants: Therapeutic properties and affinity for α-adrenergic receptor binding sites in the brain. Science 199:197–198

Verdiére M. Rose C. Schwartz J.C. (1975) Synthesis and release of histamine on slices from rat hypothalamus. Eur J Pharmacol 34:157–168

Wahl M. Kuschinsky W. (1979) TThe dilating effect of histamine on pial arteries of cats and its mediation by H2 receptors. Circ Res 44:161–165

Weiner R.I. Ganong W.F. (1978) Role of brain monoamines and histamine in regulation of anterior pituitary secretion. Physiol Rev 58:905–976

Weinreich D. Weiner C. McCaman R. (1975) Endogenous levels of histamine in single neurones isolated from CNS of Aplysia Californica. Brain Res 84:341–345

Wilhelm D.L. (1962) The mediation of increased vascular permeability in inflammation. Pharmacol Rev 14:251–280

Wolff J.R. Schieweck C.L. Emmenegger H. Meier-Ruge W. (1975) TCerebrovascular ultrastructural alterations after intra-arterial infusions of ouabain, scilla-glycosides, heparin and histamine. Acta Neuropathol (Berl) 31:45–58

Zweifach B.W. (1964) Microcirculatory aspects of tissue injury. Ann NY Acad Sci 116:831–838