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Research article

First published 2013-9

Development of a Pharmacodynamic Assay Based on PLCγ2 Phosphorylation for Quantifying Spleen Tyrosine Kinase (SYK)–Bruton’s Tyrosine Kinase (BTK) Signaling

Jonathan Hsu, Jun Zhang, Chris Kitson [...]

Journal of Biomolecular Screening

Open access

Research article

First published 2018-10

Homogeneous BTK Occupancy Assay for Pharmacodynamic Assessment of Tirabrutinib (GS-4059/ONO-4059) Target Engagement

Helen Yu, Hoa Truong, Scott A. Mitchell [...]

Journal of Biomolecular Screening

Free access

Research article

First published 2018-9

Pharmacokinetics/Pharmacodynamics of Dabigatran 75 mg Twice Daily in Patients With Nonvalvular Atrial Fibrillation and Severely Impaired Renal Function

Jack L. Martin, Habib Esmaeili, Raymond C. Manuel [...]

Journal of Cardiovascular Pharmacology and Therapeutics

Retricted access

Research article

First published 2006-11

A rapid method for generating and characterizing anti-variable region monoclonal antibodies

Kimberly Staquet, Deborah Kwok, Michael A. Rycyzyn [...]

Human Antibodies

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Research article

First published 2018-6

Sedative Plasma Concentrations and Delirium Risk in Critical Illness

Joanna L. Stollings, Jennifer L. Thompson, Benjamin A. Ferrell [...]

Annals of Pharmacotherapy

Retricted access

Research article

First published 1982-7

A Practical Guide to Interactions Involving Theophylline Kinetics

James C. McElnay, Gary D. Smith, Dennis K. Helling

Annals of Pharmacotherapy

Free access

Research article

First published 2013-9

A Novel Prothrombin Time Assay for Assessing the Anticoagulant Activity of Oral Factor Xa Inhibitors

Yu Chen Barrett, Zhaoqing Wang, Robert M. Knabb

Clinical and Applied Thrombosis/Hemostasis

Retricted access

Research article

First published 2010-08

A Plate-Based Assay to Measure Cellular ERK Substrate Phosphorylation: Utility for Drug Discovery of the MAPK-Signaling Cascade

Sreemathy Ramaswamy, Ivana Yen, Steve Sideris [...]

ASSAY and Drug Development Technologies

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Review article

First published 2011-11

Platelet Aggregation Quality Control in a Multicenter,Phase 2 Clinical Trial

James McRedmond

Therapeutic Innovation & Regulatory Science

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Other

First published 1997-10

Considerations in Assessing the Immunotoxic Potential of Investigational Drugs *

Kenneth L. Hastings, Chang-Ho Ahn, Syed N. Alam [...]

Therapeutic Innovation & Regulatory Science

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