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Open access

Research article

First published 2023-9

Design and synthesis of novel PDE4 inhibitors as potential candidates for antidepressant agents

Yingcong Yu, Yan Zhao, Yajing Wang [...]

Journal of Chemical Research

Free access

Review article

First published 2010-10

Apremilast: a novel PDE4 inhibitor in the treatment of autoimmune and inflammatory diseases

Georg Schett, Victor S. Sloan, Randall M. Stevens [...]

Therapeutic Advances in Musculoskeletal Disease

Open access

Research article

First published 2024-11

Design and synthesis of novel curcumin derivatives as potent PDE4 inhibitors for the treatment of depression

Haodong Zhou, Yulan Zhu, Xianfeng Huang

Journal of Chemical Research

Free access

Research article

First published 2006-1

Characterization of the Inflammatory Response to a Highly Selective PDE4 Inhibitor in the Rat and the Identification of Biomarkers that Correlate with Toxicity

Gregory N. Dietsch, Chris R. Dipalma, Russell J. Eyre [...]

Toxicologic Pathology

Retricted access

Research article

First published 2018-02

Investigation of Lung Pharmacokinetic of the Novel PDE4 Inhibitor CHF6001 in Preclinical Models: Evaluation of the PreciseInhale Technology

Alessandro Fioni, Ewa Selg, Valentina Cenacchi [...]

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Open access

Research article

First published 2026

The effects of the PDE4 inhibitor roflumilast on cognitive performance after a cerebrovascular accident: a double-blind randomized placebo-controlled trial with an open label extension (ROSTMEMA)

Jill Kerckhoffs, Ieke Winkens, Arthur Ooghe [...]

Journal of Psychopharmacology

Open access

Review article

First published 2022-6

The Role of the Pharmacist in Optimizing Outcomes With Roflumilast,a PDE4 Inhibitor for the Treatment of COPD

Dennis Williams

Journal of Pharmacy Practice

Retricted access

Research article

First published 2026

Enhancement of memory network activity in schizophrenia patients by phosphodiesterase-4 (PDE4) inhibitor,roflumilast: A pilot study

Klaudia Stanoch, Donni Ann Staley, Peter Hawkins [...]

Journal of Psychopharmacology

Open access

Research article

First published 2025-01

Ensifentrine in COPD patients taking long-acting bronchodilators: A pooled post-hoc analysis of the ENHANCE-1/2 studies

Mark Dransfield, Nathaniel Marchetti, Ravi Kalhan [...]

Chronic Respiratory Disease

Free access

Research article

First published 2004-04

The Toxicity of SCH 351591,a Novel Phosphodiesterase-4 Inhibitor,in Cynomolgus Monkeys

Patricia E. Losco, Ellen W. Evans, Stephen A. Barat [...]

Toxicologic Pathology

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