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Open access

Research article

First published 2025

Prophylactic PDE4 and PDE4B inhibition reduce lesion size and neutrophil infiltration following ischemic stroke in male mice

Laura Ponsaerts, Lotte Alders, Melissa Schepers [...]

Journal of Cerebral Blood Flow & Metabolism

Free access

Research article

First published 2013-6

Selective Inhibition of PDE4 in Wistar Rats Can Lead to Dilatation in Testis,Efferent Ducts,and Epididymis and Subsequent Formation of Sperm Granulomas

Anke Heuser, Lars Mecklenburg, Deborah Ockert [...]

Toxicologic Pathology

Retricted access

Research article

First published 2016-08

PDE4 Inhibition by Rolipram Promotes Neuronal Differentiation in Human Bone Marrow Mesenchymal Stem Cells

I-Seul Joe, Goang-Won Cho

Cellular Reprogramming

Retricted access

Research article

First published 2021-1

The effects of roflumilast,a phosphodiesterase type-4 inhibitor,on EEG biomarkers in schizophrenia: A randomised controlled trial

James Gilleen, Judith Nottage, Farah Yakub [...]

Journal of Psychopharmacology

Open access

Research article

First published 2023-9

Design and synthesis of novel PDE4 inhibitors as potential candidates for antidepressant agents

Yingcong Yu, Yan Zhao, Yajing Wang [...]

Journal of Chemical Research

Retricted access

Research article

First published 2008-11

Improved sensorimotor function by rolipram following focal cerebral ischemia in rats

Sonja Hätinen, Mikko Sairanen, Jouni Sirviö [...]

Restorative Neurology and Neuroscience

Free access

Research article

First published 2006-1

Characterization of the Inflammatory Response to a Highly Selective PDE4 Inhibitor in the Rat and the Identification of Biomarkers that Correlate with Toxicity

Gregory N. Dietsch, Chris R. Dipalma, Russell J. Eyre [...]

Toxicologic Pathology

Open access

Research article

First published 2018-11

Synergistic effect of phosphodiesterase 4 inhibitor and serum on migration of endotoxin-stimulated macrophages

Jing-Xing Yang, Te-Chih Hsiung, Fu-Chun Weng [...]

Innate Immunity

Open access

Research article

First published 2024-11

Design and synthesis of novel curcumin derivatives as potent PDE4 inhibitors for the treatment of depression

Haodong Zhou, Yulan Zhu, Xianfeng Huang

Journal of Chemical Research

Retricted access

Research article

First published 2011-06

A Selective Phosphodiesterase-4 Inhibitor Reduces Leukocyte Infiltration,Oxidative Processes,and Tissue Damage after Spinal Cord Injury

Feng Bao, Jennifer C. Fleming, Roozbeh Golshani [...]

Journal of Neurotrauma

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