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First published 2011-5

Assessing a Drug's Proarrhythmic Liability: An Overview of Computer Simulation Modeling,Nonclinical Assays,and the Thorough QT/QTc Study

Lawrence Z. Satin, Todd A. Durham, J. Rick Turner

Therapeutic Innovation & Regulatory Science

Free access

Review article

First published 2016-1

A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm

Bernard Fermini, Jules C. Hancox, Najah Abi-Gerges [...]

Journal of Biomolecular Screening

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Other

First published 2005-10

ICH E14: A New Regulatory Guidance on the Clinical Evaluation of QT/QTc Internal Prolongation and Proarrhythmic Potential for Non-antiarrhythmic Drugs *

Philip T. Sager, Thierry Nebout, Borje Darpo

Therapeutic Innovation & Regulatory Science

Retricted access

Research article

First published 2014-3

Evaluation of Assay Sensitivity and the Concentration-Effect Relationship of Moxifloxacin in a QT/QTc Study in Japan

Masanari Shiramoto, Hinako Uchimaru, Yoshikazu Kaji [...]

Therapeutic Innovation & Regulatory Science

Free access

Review article

First published 2011-12

Towards a better understanding of QT interval variability

Larisa G. Tereshchenko, Ronald D. Berger

Therapeutic Advances in Drug Safety

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Research article

First published 2015-5

Lessons Learned From Hundreds of Thorough QT Studies

Joanne Zhang, Huifang Chen, Yi Tsong [...]

Therapeutic Innovation & Regulatory Science

Free access

Research article

First published 2019-1

A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium

Emmanuel Boulay, Matthew M. Abernathy, Ray Chui [...]

International Journal of Toxicology

Search results

Assessing a Drug's Proarrhythmic Liability: An Overview of Computer Simulation Modeling,Nonclinical Assays,and the Thorough QT/QTc Study

A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm

ICH E14: A New Regulatory Guidance on the Clinical Evaluation of QT/QTc Internal Prolongation and Proarrhythmic Potential for Non-antiarrhythmic Drugs *

Evaluation of Assay Sensitivity and the Concentration-Effect Relationship of Moxifloxacin in a QT/QTc Study in Japan

Towards a better understanding of QT interval variability

Lessons Learned From Hundreds of Thorough QT Studies

A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium