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Research article

First published 2010-02

Therapeutic Manipulation of the HIF Hydroxylases

Simon Nagel, Nick P. Talbot, Jasmin Mecinović [...]

Antioxidants & Redox Signaling

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Research article

First published 2020-2

Carcinogenicity Assessment of Daprodustat (GSK1278863),a Hypoxia-Inducible Factor (HIF)-Prolyl Hydroxylase Inhibitor

David F. Adams, Mark S. Watkins, Luc Durette [...]

Toxicologic Pathology

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Research article

First published 2014-12

Short-term treatment with a novel HIF-prolyl hydroxylase inhibitor (GSK1278863) failed to improve measures of performance in subjects with claudication-limited peripheral artery disease

Eric Olson, Laura Demopoulos, Thomas F Haws [...]

Vascular Medicine

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Review article

First published 2010-02

Prolyl Hydroxylase Domain Inhibitors: A Route to HIF Activation and Neuroprotection

Sarah K. Harten, Margaret Ashcroft, Patrick H. Maxwell

Antioxidants & Redox Signaling

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Research article

First published 2008-12

Antioxidants,HIF Prolyl Hydroxylase Inhibitors or Short Interfering RNAs to BNIP3 or PUMA,Can Prevent Prodeath Effects of the Transcriptional Activator,HIF-1α,in a Mouse Hippocampal Neuronal Line

Leila R. Aminova, Ambreena Siddiq, Rajiv R. Ratan

Antioxidants & Redox Signaling

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Research article

First published 2010-02

HIF Prolyl Hydroxylase Inhibitors Prevent Neuronal Death Induced by Mitochondrial Toxins: Therapeutic Implications for Huntington's Disease and Alzheimer's Disease

Zoya Niatsetskaya, Manuela Basso, Rachel E. Speer [...]

Antioxidants & Redox Signaling

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Review article

First published 2014-06

Molecular Mechanisms of Action and Therapeutic Uses of Pharmacological Inhibitors of HIF–Prolyl 4-Hydroxylases for Treatment of Ischemic Diseases

Vaithinathan Selvaraju, Narasimham L. Parinandi, Ram Sudheer Adluri [...]

Antioxidants & Redox Signaling

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Research article

First published 2009-07

Characterization of a Robust Enzymatic Assay for Inhibitors of 2-Oxoglutarate-Dependent Hydroxylases

Kimon C. Kanelakis, Heather L. Palomino, Lina Li [...]

Journal of Biomolecular Screening

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Research article

First published 2017-11

Evaluation of the Carcinogenic Potential of Roxadustat (FG-4592),a Small Molecule Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase in CD-1 Mice and Sprague Dawley Rats

James Beck, Carroll Henschel, James Chou [...]

International Journal of Toxicology

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Research article

First published 2005-8

Hypoxic preconditioning increases expression of HIF prolyl hydroxylase 2 (Egln1) in neonatal rat brain

Nicole M Jones, Philip M Beart

Journal of Cerebral Blood Flow & Metabolism

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