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Abstract

BACKGROUND:

With the widespread use of low-dose spiral computed tomography (LDCT) and increasing awareness of personal health, the detection rate of pulmonary nodules is steadily rising.

OBJECTIVE:

To evaluate the success rate and safety of two different models of Hook-Wire needle localization procedures for pulmonary small nodule biopsy.

METHODS:

Ninety-four cases with a total of 97 pulmonary small nodules undergoing needle localization biopsy were retrospectively analyzed. The cases were divided into two groups: Group A, using breast localization needle steel wire (Bard Healthcare Science Co., Ltd.); Group B, using disposable pulmonary nodule puncture needle (SensCure Biotechnology Co., Ltd.). All patients underwent video-assisted thoracoscopic surgery (VATS) for nodule removal on the same day after localization and biopsy. The puncture localization operation time, success rate, complications such as pulmonary hemorrhage, pneumothorax, hemoptysis, and postoperative comfort were observed and compared.

RESULTS:

In Group A, the average localization operation time for 97 nodules was 15.47 $\pm$ 5.31 minutes, with a success rate of 94.34%. The complication rate was 71.69% (12 cases of pneumothorax, 35 cases of pulmonary hemorrhage, 2 cases of hemoptysis), and 40 cases of post-localization discomfort were reported. In Group B, the average localization operation time was 25.32 $\pm$ 7.83 minutes, with a 100% success rate. The complication rate was 29.55% (3 cases of pneumothorax, 15 cases of pulmonary hemorrhage, 0 cases of hemoptysis), and 3 cases reported postoperative discomfort. According to the data analysis in this study, Group B had a lower incidence of puncture-related complications than Group A, along with a higher success rate and significantly greater postoperative comfort.

CONCLUSIONS:

The disposable pulmonary nodule puncture needle is safer and more effective in pulmonary small nodule localization biopsy, exhibiting increased comfort compared to the breast localization needle. Additionally, the incidence of complications is significantly lower.

Keywords

CT-guided pulmonary small nodule needle localization Hook-Wire needle

1. Introduction

With the widespread use of low-dose spiral computed tomography (LDCT) and increasing awareness of personal health, the detection rate of pulmonary nodules is steadily rising. Research [1] indicates an incidence of 35.5% for pulmonary nodules, with 0.54% being diagnosed as lung cancer. The National Lung cancer Screening Trial (NLST) results show a 20% reduction in lung cancer mortality with LDCT screening compared to standard chest X-rays [2]. Due to the extensive application of LDCT, more early-stage pulmonary nodules, especially Ground Glass nodules (GGN), are being discovered. Currently, the primary treatment for pulmonary nodules is video-assisted thoracoscopic surgery (VATS), which is an effective, minimally invasive, and feasible therapeutic technique [3]. However, performing VATS for the resection of pulmonary nodules, especially invisible and untouchable GGN, poses significant challenges. Existing literature has highlighted the higher safety of hook-wire needle localization for pulmonary nodules before VATS, not only reducing surgery time but also significantly decreasing the chance of conversion to open thoracotomy.

Various techniques for pulmonary nodule localization have been reported, including Hook-Wire needle, spring coil, liquid material injection localization (methylene blue, etc.), bronchoscopy-assisted CT virtual 3D (three dimensions) assisted localization, each with its own advantages and disadvantages [4]. According to our previous experience and literature review, Hook-Wire needle is the most commonly used and reliable method for localization. However, there is limited comparative research among different models of Hook-Wire needles. In this study, we aim to collect and analyze information on various complications and patient comfort during surgeries involving two different models of needles (breast localization needle and disposable pulmonary nodule puncture needle). Our goal is to explore the effectiveness and safety advantages of these two needle models in nodule biopsy localization.

2. Materials and methods

This study employed two different models of Hook-Wire localization needles. The first one is the breast localization needle [Bard Healthcare Science (Shanghai) Co., Ltd.] with a standard number: National Medical Devices Registration: 20163771636, specifications: 20 G/10.7 cm. It is a tail-wired localization needle (Group A). The second one is the disposable pulmonary nodule puncture needle [Ningbo SensCure Biotechnology Co., Ltd.] with National Medical Devices Registration: 20193150175, specifications: 20 G/10 cm. It is a tail-soft-wired localization needle (Group B). Surgical time, complications, patient comfort, puncture depth, and other factors were statistically collected and analyzed during the puncture localization to compare the efficiency of the Hook-Wire needle puncture method and its clinical benefits.

2.1 Clinical patient data and grouping

Patient data were collected from Xiamen Chang Gung Hospital Radiology Department from June 2019 to April 2023 for CT-guided pulmonary small nodule localization biopsy. A total of 94 patients with 97 pulmonary nodules were included (Table 1), including 46 males and 48 females. Patients using different needles were divided into two groups, namely Group A using the breast localization needle (53 nodules) and Group B using the disposable pulmonary nodule puncture needle (44 nodules).

Table 1
Basic parameters

	Bard Localization Needles 53 (Group A)	SensCure Localization Needles 44 (Group B)
Average age	53.32 $\pm$ 10.21	51.11 $\pm$ 13.19
Gender
Male	32	14
Female	21	27
Nodule diameter	$<$ 10 mm	$<$ 10 mm
Nodule localization
Left upper lobe	8	8
Left lower lobe	12	8
Right upper lobe	14	11
Right middle lobe	2	6
Right lower lobe	17	11

Figure 1.

Depicts the case of a single patient with a nodule in the left lower lobe (highlighted by yellow arrows) in the right lateral decubitus position. Puncture was performed using a breast localization needle: A. Pre-puncture localization of the nodule.B. After adjusting the angle of the puncture needle, it was inserted into the lung, revealing alveolar hemorrhage (indicated by red arrows) and a small pneumothorax (indicated by blue arrows). C. Release of the hook-wire, with the distal end anchored (indicated by green arrows) within 1 cm of the lesion. D. Post-release scan confirming the position of the localization needle and assessing lung complications. The steel wire tail (indicated by black arrows) was then externally ligated.The difficulty in securing the metal tail wire after hook-wire anchoring may lead to increased friction with the chest wall, resulting in a higher likelihood of secondary pneumothorax and alveolar hemorrhage, contributing to a less favorable patient experience.E and F: Surgical field views observing the condition of the hook-wire and postoperative excised pathological specimens, with the specimens removed for further examination after detaching the localization needle.

2.2 Methods

All patients underwent procedures guided by Siemens Dual-Source CT (SOMATOM Force, 2 $\times$ 96 rows, 2 $\times$ 192 layers, 90 mSv, 61–69 mAs, layer thickness 2.5 mm). Prior to the operation, patients received preoperative counseling, psychological support, and signed informed consent. AI was utilized to measure the number, size, and depth of the target lesions, simulating needle insertion paths and depths. Local anesthesia was administered during the procedure. Before puncture, routine full lung scans were performed. The puncture needle was inserted into the chest wall at the predetermined depth, and a verification scan was conducted to adjust the needle angle. Patients were instructed to inhale and hold their breath while the needle was inserted. Subsequently, a local CT scan around the target lesion was performed to confirm the needle’s position and depth, ensuring it reached the target lesion depth. The hook-wire was released once the ideal position was achieved. After securing the hook-wire, a slight attempt to pull the tail wire should encounter resistance.If the preset position was suboptimal, a repeat CT scan was conducted before the puncture needle entered the pleura to make necessary adjustments. This process was repeated until the hook-wire was embedded within the target lesion or within 1 cm of it (see Fig. 1 for Group A and Fig. 2 for Group B). The exposed skin at the tail end was immediately bandaged and covered with sterile gauze. A low-dose lung CT scan was performed again to observe the position of the localization needle, as well as any lung bleeding or pneumothorax. Finally, the patient was transferred to the operating room for planned video-assisted thoracoscopic surgery (VATS).

Figure 2.

Illustrates the case of the same patient with a nodule in the right upper lobe (highlighted by yellow arrows) in the supine position. Puncture was performed using a disposable pulmonary nodule puncture needle: A. Pre-puncture localization of the nodule. B. After adjusting the angle of the puncture needle(indicated by green arrows), it was inserted into the lung. C. Post-release scan confirming the position of the localization needle (indicated by green arrows) and assessing lung complications. The steel wire tail was then externally ligated. No alveolar hemorrhage or pneumothorax was observed within the lung, and the tail wire was easily secured after hook-wire anchoring, providing a comfortable experience for the patient. D and F. Surgical field views observing the condition of the hook-wire (indicated by black arrows) and postoperative excised pathological specimens. The specimens were sent for examination, carrying the hook-wire along for further analysis.

2.3 Outcome measures and data processing

(1) Incidence of alveolar hemorrhage during the localization biopsy procedure with the two types of needles; (2) Incidence of pneumothorax during the localization biopsy procedure with the two types of needles; (3) Incidence of hemoptysis during the localization biopsy procedure with the two types of needles; (4) Decoupling situations during surgical thoracoscopy (That is, during surgery, the positioning needle is removed from its original position and floats in the chest cavity); (5) Average puncture time; (6) Success rate of puncture localization; (7) Number of patients with discomfort after the puncture (e.g. cough, pain at the puncture site, hemoptysis, etc.) (8) Number of cases of air embolism during puncture (Table 2). Data were analyzed using SPSS 25.0 (IBM SPSS Statistics, IBM Corp) for statistical analysis. Continuous variables are presented as mean $\pm$ standard deviation or median (range), and categorical variables are presented as counts or percentages. Chi-square test or Fisher’s exact test was used for the comparison of binary variables. A p-value less than 0.05 was considered statistically significant. This study was approved by the Xiamen Chang Gung Hospital Review Committee, and the requirement for informed consent for the use of patient records was waived. Informed consent for surgery was obtained from all patients before the procedure. All methods were conducted following the principles of the Helsinki Declaration.

Table 2
Incidence of complications in nodule localization

	Bard Localization Needles 53 (Group A)		SensCure Localization Needles 44 (Group B)		X2	$P$ -value
	$n$	%	$n$	%
Pneumothorax	12	22.64	3	9.76	4.60	$P<$ 0.05
Alveolar Hemorrhage	35	66.04	15	34.09	9.82	$P<$ 0.05
Decoupling during Thoracoscopy	3	5.66	0	0	–	$P<$ 0.05
Hemoptysis	2	3.77	0	0	–	$P<$ 0.05
Localization Success Rate	94.34%	(50/53)	100%	(44/44)	–	$P<$ 0.05
Complication Incidence Rate	38/53	71.69%	13/44	29.55%
Average Localization Time	15.47 $\pm$ 5.31 (min)		25.32 $\pm$ 7.83 (min)
Localization Success Rate	94.34%	(50/53)	100%	(44/44)
Number of Postoperative Discomfort Cases	40		3
Number of air embolism during puncture	0		0

3. Results and analysis

By collecting and analyzing data from 94 patients (97 pulmonary nodules) in our hospital, the results are summarized as follows: For patients in Group A, who used the Bard localization needles, there were 53 cases, including 32 males and 21 females, with an average age of 53.32 $\pm$ 10.21 years. Pneumothorax occurred in 12 cases, accounting for 22.64%; alveolar hemorrhage occurred in 35 cases, accounting for 66.04%; hemoptysis occurred in 2 cases, accounting for 3.77%; decoupling during thoracoscopy occurred in 3 cases, accounting for 5.66%. Postoperative discomfort was reported by 40 cases, accounting for 75.41%. For patients in Group B, who used SensCure localization needles, there were 41 cases, including 14 males and 27 females, with an average age of 51.11 $\pm$ 13.19 years. Pneumothorax occurred in 4 cases, accounting for 9.76%; alveolar hemorrhage occurred in 13 cases, accounting for 31.71%; there were no cases of hemoptysis (0.00%) or decoupling during thoracoscopy. Postoperative discomfort was reported by 3 cases, accounting for 6.82%. According to clinical observation, the discomfort of patients was mainly manifested in pain at the puncture point. In group A, 40 cases were mainly caused by the friction of the puncture needle tail, and in group B, 3 cases were mainly caused by the weakened effect of local anesthesia due to the longer operation time. Moreover, the discomfort manifested in cough and hemoptysis, which had a certain correlation with alveolar hemorrhage after puncture. According to the confirmed CT observations during and after the puncture and the literature reviewed, no air embolization appeared in all patients, which may be because the puncture involved small blood vessels, so the incidence of embolization was very low. The localization success rate was 94.34% in Group A (50/53) and 100% in Group B (44/44). Statistical analysis revealed no significant differences between the two groups ( $P<$ 0.05). The lower success rate in Group A may be attributed to the shallow position of the punctured nodules. After needle release, patients in Group A experienced a strong foreign body sensation, and the metal wire easily rubbed against the pleura repeatedly. The shallow position of the nodules and repeated traction may lead to decoupling. Moreover, patients in Group A often reported discomfort and had restricted postoperative positioning. In contrast, Group B achieved a 100% success rate in localization. Patients in Group B were not restricted in positioning after the puncture, and the soft tail wire was less likely to rub against the pleura repeatedly, resulting in significantly higher comfort levels. In the comparison of postoperative complications, Group B exhibited a lower incidence of alveolar hemorrhage and pneumothorax during the localization procedure compared to Group A. In this study, the occurrence of alveolar hemorrhage and pneumothorax was related to the tail wire of the hook needle. The retention of the metal tail wire, repeated friction against the pleura, and patient positioning changes contributed to these complications. Some cases were associated with greater puncture depth, consistent with findings by scholars like Tyler Sargent [5]. Group B did not experience any cases of postoperative hemoptysis or decoupling during thoracoscopy. However, Group B had a longer average puncture time, which may be related to the operator’s proficiency and the method of data collection (the time interval was calculated from the beginning of needle puncture to needle release in Group A, while it was calculated from the positioning image to the end of puncture in Group B). Therefore, the analysis of data from this study confirms that the complications associated with the use of disposable lung nodule puncture needles are lower.

4. Discussion

With the increasing use of low-dose spiral CT in health examinations, the proportion of patients with pulmonary nodules requiring surgical treatment is rising. Currently, single-port video-assisted thoracoscopic surgery (VATS) is commonly used for the resection of pulmonary nodules. However, unclear preoperative localization of pulmonary nodules can make it challenging to identify them during thoracoscopic surgery, especially for non-palpable ground glass nodules. This can lead to prolonged surgery times, increased postoperative complications, and ultimately extended hospital stays. Therefore, precise preoperative localization of pulmonary nodules is crucial [6]. Currently, pulmonary nodule localization methods include CT-guided percutaneous puncture-assisted localization, bronchoscopic puncture-assisted localization, and CT virtual 3D-assisted localization [7]. Among the commonly used CT-guided percutaneous puncture-assisted localization methods, there are techniques such as percutaneous Hook-wire localization [8], percutaneous spring coil localization [9, 10], and percutaneous injection of liquid materials for localization (e.g., methylene blue) [11, 12, 13, 14, 15]. Hook-wire localization is the most commonly used method in CT-guided percutaneous puncture-assisted localization [16]. In the two types of needles studied in this paper, Group A’s localization needle has a metal hook at the tip followed by a metal wire. However, the metal wire is prone to displacement and detachment, resulting in a higher failure rate, observed in three cases (5.66%) in this group. The rigid and sharp hook wire causes twisting stress on the lung parenchyma and movement of the chest wall, causing significant discomfort or pain. This leads to an increased likelihood of intraoperative and postoperative alveolar hemorrhage and pneumothorax. Postoperatively, patients can only adopt a passive position due to the strong discomfort caused by the friction and pain of the steel wire, resulting in a poor overall experience. This is generally consistent with literature reports [17]. In contrast, Group B’s soft tail wire conforms better to the puncture hole, causing less friction and traction. Postoperatively, patients can adopt a comfortable position, and the chances of decoupling and subsequent trauma-related alveolar hemorrhage and pneumothorax are significantly reduced.In other literature, the “dragging tail” spring coil localization method requires secondary release of the spring coil, increasing the number of CT scans and posing a risk of localization failure [18]. Additionally, the depth of spring coil release is closely related to the operator’s experience. However, for patients with pleural adhesions and pigmentation on the lung surface, the surgery time and intraoperative nodule removal time are shorter compared to patients localized with methylene blue [19]. In the injection of liquid material localization method, methylene blue is commonly used [21], but its rapid diffusion requires immediate surgery post-puncture, and it is challenging to identify on the lung surface with pigment deposition [22, 23]. Bronchoscopic puncture-assisted localization techniques require the use of electromagnetic navigation bronchoscopy [10, 20], and CT virtual 3D-assisted localization techniques involve the use of 3D printing technology to create a localization template. Both of these techniques have high equipment requirements, and only a few institutions currently employ them. Therefore, finding a safe, accurate, and convenient localization method is crucial for the clinical treatment of pulmonary nodules. In this study, the use of a disposable pulmonary nodule puncture needle effectively reduced the occurrence of decoupling during thoracoscopic surgery. Furthermore, during the surgical process, the CT zone localization method accurately identified the lesion’s position, preventing excessive removal and missection of lung tissue. This not only shortened the surgery time but also reduced trauma to the patient, preserved more lung tissue, lowered the risk of postoperative complications, increased the surgical success rate, and promoted patient recovery. Additionally, compared to the breast localization puncture needle, the disposable pulmonary nodule puncture needle had a lower incidence of complications and significantly higher patient comfort.

5. Conclusion

In conclusion, among the various preoperative localization methods, the Hook-Wire needle localization method stands out for its simplicity, reliable positioning, high safety, and low complication rate. This study confirms that preoperative localization with a disposable pulmonary nodule puncture needle is safer, with a lower complication rate and higher patient comfort. This approach prevents intraoperative missection and facilitates the smooth progress of VATS surgery. It is worthy of clinical promotion and use.

Footnotes

Conflict of interest

None to report.

References

Lung cancer group of respiratory disease branch of Chinese Medical Association and expert group of China Lung Cancer Prevention and Control Alliance, “Chinese expert consensus on diagnosis and treatment of pulmonary nodules (2018 edition)”, Chinese Journal of Tuberculosis and Respiratory Medicine. 2018; 41(10): 9.

Mcnittgray

. Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening. N Engl J Med. 2011; 365: 395-409.

Galetta

Rampinelli

Funicelli

, et al. CT-guided percutaneous radiotracer localization and resection of indistinct/small pulmonary lesions. Ann Thorac Surg. 2019; 108(1): 852-858. doi: 10.1016/j.athoracsur.2019.03.102.

Nardini

Dunning

. Pulmonary nodules precision localization techniques. Fut Oncol. 2020. doi: 10.2217/fon-2019-0069.

Tyler

Nathan

, et al. Risk Factors for Pneumothorax Development Following CT-Guided Core Lung Nodule Biopsy. Original Investigation. May 25 2021. doi: 10.1097/LBR0000000000000816.

Huang

Zhou

Jiang

. Clinical application and improvement of Hookwire in locating small lung lesions under CT guidance. Chinese Journal of Thoracic and Cardiovascular Surgery. 2015; 31(6): 366-368.

Nardini

Dunning

. Pulmonary nodules precision localization techniques. Future Oncol. 2020; 16(16s): 15-19.

Liu

, et al. Application of 3D imaging software localization in the video-asisited thoracoscopic resection of pulmonary ground glass nodule. J Xinxiang Med Univ. 2021; 38(2): 173-175.

Zhao

Chen

, et al. Computed tomography-guided preoperative semi-rigid hook-wire localization of small pulmonary nodules: 74 cases report. J Cardiothorac Surg. 2019; 14(1): 149.

10.

Jiao

Zhou

, et al. Application of CT-guided microcoil localization in single utility port video-assisted thoracoscopic surgery for small pulmonary nodules (diameter ⩽ 15 mm): a retrospective cohort study. Chin J Clin Thorac Cardiovasc Surg. 2022; 29(1): 68-73.

11.

Rodriguesjcl

Hanneman

, et al. CT guided microcoil pulmonary nodule localization prior to video-assisted thoracoscopic surgery: diagnostic utility and recurrence-free survival. Radiology. 2019; 291(1): 214-222.

12.

Cornella

Repper

Palafox

, et al. A surgeon’s guide for various lung nodule localization techniques and the newest technologies. Innovations (Phila). 2021; 16(1): 26-33.

13.

Hasegawa

Kuroda

Sato

, et al. The utility of indigo carmine and lipiodol mixture for preoperative pulmonary nodule localization before video-assisted thoracic surgery. J Vasc Interv Radiol. 2019; 30(3): 446-452.

14.

Fan

Yang

, et al. Multicenter, prospective, observational study of a novel technique for preoperative pulmonary nodule localization. J Thorac Cardiovasc Surg. 2020; 160(2): 532-539.

15.

Jiang

Lin

Zhao

, et al. Preoperative computed tomography-guided localization for pulmonary nodules with glue and dye. Thorac Cardiovasc Surg. 2020; 68(6): 525-532.

16.

Wang

Zeng

Zhao

, et al. A safe and novel method for video-assisted thoracic surgery preoperative localization of small pulmonary nodules by using ZT medical glue (2-octyl cyanoacrylate). Surg Oncol. 2020; 33: 164-169.

17.

Chen

Zhao

, et al. Clinical analysis of CTguided preoperative Hookwire localization of pulmonary nodules in 102 patients. Chin J Clin Thorac Cardiovasc Surg. 2022; 29(1): 56-61.

18.

Yang

Zhao

Sui

, et al. Comparative study on preoperative localization techniques using microcoil and hookwire by propensity score matching. Thorac Cancer. 2020; 11(6): 1386-1395.

19.

Zhang

, et al. Modified microcoil for preoperative localization of solitary pulmonary nodules: a prospective, single-arm, multicenter clinical study. J Vasc Interv Radiol. 2021; 32(10): 1470-1477e1.

20.

Sun

Liu

Gao

, et al. Application of modified tailed microcoil in preoperative localization of small pulmonary nodules: a retrospective study. Thorac Cardiovasc Surg. 2020; 68(6): 533-539.

21.

Wang

Liu

Yang

, et al. Effectiveness and safety of CT-guided percutaneous intrapulmonary injection of indocyanine green for localization of pulmonary nodules and ground glass opacity. Nat Med J China. 2020; 100(7): 538-540.

22.

Kokh Huang

Lee

, et al. A simple and efficient method to perform preoperative pulmonary nodule localization: CT-guided patent blue dye injection. ClinImaging. 2019; 58: 74-79.

23.

Tian

Wang

Yue

, et al. Comparison of computed tomographic imaging-guided hook wire localization and electromagnetic navigation bronchoscope localization in the resection of pulmonary nodules: a retrospective cohort study. SciRes. 2020; 10(1): 21459.

Clinical application of two types of Hook-Wire needle localization procedures for pulmonary small nodule biopsy

Abstract

BACKGROUND:

OBJECTIVE:

METHODS:

RESULTS:

CONCLUSIONS:

Keywords

1. Introduction

2. Materials and methods

2.1 Clinical patient data and grouping

Table 1 Basic parameters

Table 2 Incidence of complications in nodule localization

4. Discussion

5. Conclusion

Footnotes

Conflict of interest

References

Table 1
Basic parameters

Table 2
Incidence of complications in nodule localization