Melanoma is one of the widespread skin cancers that has affected millions in past decades. Detection of skin cancer at preliminary stages may become a source of reducing mortality rates. Hence, it is required to develop an autonomous system of reliable type for the detection of melanoma via image processing. This paper develops an independent medical imaging technique using Self-Attention Adaptation Generative Adversarial Network (SAAGAN). The entire processing model involves the process of pre-processing, feature extraction using Scale Invariant Feature Transform (SIFT), and finally, classification using SAAGAN. The simulation is conducted on ISIC 2016/PH2 datasets, where 10-fold cross-validation is undertaken on a high-end computing platform. The simulation is performed to test the model efficacy against various images on several performance metrics that include accuracy, precision, recall, f-measure, percentage error, Matthews Correlation Coefficient, and Jaccard Index. The simulation shows that the proposed SAAGAN is more effective in detecting the test images than the existing GAN protocols.
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