Abstract
Marked nonlinearity between stress and strain was observed during the clotting of plasma and blood. Dynamic elastic modulus and loss modulus of plasma clot decreased with the frequency and amplitude of oscillation given to the plasma during clotting. The breaking amplitude for the clot was higher if the larger amplitude of oscillation was used during clotting.
When the measuring amplitude was small, the elastic modulus increased with the rise of temperature. On the other hand, when the measuring amplitude was large, the modulus decreased with the rise of temperature. These results can be explained by assuming that the fibrin strands between crosslinks in the network are in a fairly elongated state. When the plasma was clotted under a sinusoidal shear strain of about 0.08, the number of fibrin monomers between crosslinks was estimated to be about 20.
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