Abstract
A new process for synthesis of (2S,3S)-2-ethyl-3-methylvaleramide has been developed via the key step of a diastereoselective alkylation reaction using non-cross-linked polystyrene (NCPS) supported (4S)-2-phenylimino-2-oxazolidine as a chiral auxiliary. This method is efficient with the target product obtained in 99.24% ee and 38.4% overall yield and the chiral auxiliaries can be recovered quantitatively by simple filtration.
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