Abstract
The asymmetric synthesis of both (R)-and (S)-arundic acid has been achieved via the key step of a stereoselective alkylation reaction using non-cross-linked polystyrene (NCPS) supported (4R)- and (4S)-2-phenylimino-2-oxazolidine as chiral auxiliaries. This method is efficient (both enantiomers were obtained in 99% ee and 60% overall yield) and the chiral auxiliaries can be recovered quantitatively by simple filtration.
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