Abstract
A green and efficient synthesis of 13 of the title compounds, three of which are novel, has been achieved via a one-pot, three-component reaction of anilines, aldehydes and barbituric acids, catalysed by 1,4-diaza-bicyclo[2.2.2]octane (DABCO) in water at reflux. Using microwave heating, reaction times were shortened from 12 h to under a minute and yields were generally higher.
References
1.
Hzhu J.
, and
Bienayme H.
, eds, Multicomponent reactions. Wiley-VCH , Weinheim , 2005 .
2.
Li J.J.
, and
Corey E.J.
, eds, Name reactions in heterocyclic chemistry. Wiley Interscience , 2005 .
3.
Kozikowski A.P.
, J. Med. Chem. , 2009 , 52 , 2109 .
4.
Hzishiri V.K.
,
Joshi M.C.
,
Hunter R.
,
Chibale K.
,
Smith P.J.
,
Summers R.L.
,
Martin R.E.
, and
Egan T.J.
, J. Med. Chem. , 2011 , 54 , 6956 .
5.
Daoud R.
,
Desneves J.
,
Deady L.W.
,
Tilley L.
,
Scheper R.J.
,
Gros P.
, and
Georges E.
, Biochemistry , 2000 , 39 , 6094 .
6.
Khalafi-Nezhad A.
,
Sarikhani S.
,
Shahidzadeh E.S.
, and
Panahi F.
, Green Chem. , 2012 , 14 , 2876 .
7.
Yang H.
,
Tian R.
, and
Li Y.
, Front. Chem. China , 2008 , 3 , 279 .
8.
Baghernejad B.
, Eur. J. Chem. , 2010 , 1 , 54 .
9.
Kappe C.O.
, Angew. Chem. Int. Ed. , 2004 , 43 , 6250 .
10.
Loupy A.
, ed. Microwaves in organic synthesis. Wiley-VCH , Weinheim , 2002 .