Abstract
An efficient, one-pot synthesis of spiro[indole-3,9′-tetrazolo[5,1-b]quinazoline]-2,8′(1H,5′H)-dione derivatives by the reaction of isatin, 5-amino-1H-tetrazole, and 5,5-dimethylcyclohexane-1,3-dione catalysed by a superacid ([MeC(OH)2]+ClO4-) in aqueous medium is described. This protocol provides a simple one-step procedure with the advantages of easy work-up, high yield, mild reaction conditions and is environmental friendly.
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