Abstract
Ruthenium chloride plays the role of a Lewis acid catalyst for the one-pot three-component synthesis of highly functionalised tetrahydropiperidines from aromatic aldehydes, anilines and ethyl acetoacetate in ethanol at ambient temperature without any ligand or activator. The simple experimental procedure, high yields of products, no need for column chromatography, and short reaction times compared to other catalysts are some of the advantages of this method.
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