Abstract
In order to develop novel and effective anticoccidial compounds, a series of 3-(2-(benzofuran)-2-yl)-2-oxoethylquinazolinone derivatives were designed, synthesised and evaluated as potential anticoccidial drugs. The structures of these compounds were characterised by 1H NMR, IR, HRMS spectra and elemental analysis. These compounds were tested for anticoccidial activities against Eimeria tenella according to the anticoccidial index method. 6-Chloro-3-(2-(benzofuran-2-yl)-2-oxoethyl) quinazolin-4-(3H)-one exhibited significant anticoccidial activities in the chicken's diet with a dose of 18 mg kg−1.
Keywords
References
1.
Duffy C.F.
,
Mathis G.F.
, and
Power R.F.
, Vet. Parasitol. , 2005 , 130 , 185 .
2.
Gabriel I.
,
Mallet S.
,
Leconte M.
,
Fort G.
, and
Naciri M.
, Anim. Feed Sci. Technol. , 2006 , 129 , 279 .
3.
Chou T.Q.
,
Fu F.Y.
, and
Kao Y.S.
, J. Am. Chem. Soc. , 1948 , 70 , 1765 .
4.
DeSmet P.A.G.M.
Dru. , 1997 , 54 , 801
5.
Peeters J.E.
,
Derijcke J.
,
Verlinden M.
, and
Wyffels R.
, Avian Dis. , 1994 , 38 , 483 .
6.
Chapman H.D.
, Res. Vet. Sci. , 1986 , 40 , 139 .
7.
Mao Z.X.
,
Mao G.X.
,
Jin J.T.
,
Huang W.B.
, and
Faming Zhuanli (P)
, CN, 1651, 428 , 2004 .
8.
Zou Y.
,
Wu K.Q.
,
Yang Z.X.
, and
Wang Y.L.
, Chinese J. Org. Chem. , 2007 , 27 , 981 .
9.
You J.H.
,
Ye C.W.
,
Weng Y.B.
,
Mo X.H.
, and
Wang Y.L.
, Arkivoc. , 2008 , 1 , 11 .
10.
Wang Y.Y.
,
Yan C.R.
,
Weng Y.B.
,
Jin H.
, and
Chen H.
, Pest. Biochem. Physiol. , 2009 , 93 , 85 .
11.
Ye C.W.
,
You J.H.
,
Li X.F.
,
Liu Y.
, and
Wang Y.L.
, Chem. Res. Appl. , 2009 , 21 , 427 .
12.
Xie Min
;
Chen Guangmin
;
Zou Lijuan
;
Nie Kui
;
Wang Yuliang
;
Luo Juan
, Huaxue Yanjiu Yu Yingyong , 2010 , 22 , 864 .
13.
Li G.Q.
,
Kanu S.
,
Xiang F.Y.
,
Xiao S.M.
,
Zhang L.
,
Chen H.W.
, and
Ye H.J.
, Vet. Parasitol. , 2004 , 119 , 261 .
14.
Johnson J.
, and
Reid W.M.
, Exp. Parasitol. , 1970 , 28 , 30 .
15.
Li J.M.
,
Zha D.J.
, and
He G.W.
, Chin. J. Pharm. , 2000 , 31 , 289 .
16.
Mao Z.X.
,
Mao G.X.
,
Jin J.T.
,
Huang W.B.
, and
Faming Zhuanli (P)
, CN, 1651, 428 , 2004 .
17.
Zhang Y.
,
Niu Y.H.
,
Dong B.F.
, and
Wang Y.H.
, Fine Chem. , 2006 , 23 , 822 .
18.
Zabeer A.
,
Bhagat A.
,
Gupta O.P.
,
Singh G.D.
,
Youssouf M.S.
,
Dhar K.L.
,
Suri O.P.
,
Suri K.A.
,
Satti N.K.
,
Gupta B.D.
, and
Qazi G.N.
, Eur. J. Chem. , 2006 , 41 , 429 .
19.
Weinheim
, Arch. Pharm. , 1997 , 330 , 307 .
20.
Suo X.
, and
Li G.Q.
, Coccidia and coccidiosis of domestic fowl , Agriculture University of China Press , Beijing . 1998 .