Abstract
A series of novel ethyl 6-substitutedbenzyloxy-7-alkoxy-4-hydroxyquinoline-3-carboxylates have been designed and synthesised from 4-nitro-2-alkoxyphenol. Their structures have been characterised by 1H NMR, HRMS and IR spectra. Anticoccidial activities of these compounds were evaluated according to the ACI (the anticoccidial index) method. The results indicated that three of the tested compounds exhibited anticoccidial activities against Eimeria tenella in chicken feed with a dose of 27 mg/kg.
Keywords
References
1.
Duffy C.F.
,
Mathis G. F.
, and
Power R. F.
, Vet Para. , 2005 , 130 , 185 .
2.
Vasile C.
, and
Adriana T.
, CAB Rev. , 2007 , 2 , 61 .
3.
Chapman H.D.
, Avian Pathol. , 1997 , 26 , 221 .
4.
Li G.Q.
,
Kanu S.
,
Xiang F. Y.
,
Xiao S. M.
,
Zhang L.
,
Chen H. W.
, and
Ye H. J.
, Vet Para , 2004 , 119 , 261 .
5.
Chapman H.D.
, and
Rathinam T.
, Avian Dis. , 2007 , 51 , 954 .
6.
Spencer C.F.
,
Engle A.
,
Yu C. N.
,
Finch R. C.
,
Watson E. J.
,
Ebetino F. F.
, and
Johnson C. A.
, J. Med. Chem. , 1966 , 9 , 934 .
7.
Ryley J.F.
, Brit Vet J. , 1967 , 123 , 513 .
8.
Craine E.M.
,
Kouba R. F.
, and
Ray W. H.
, J. Agr. Food Chem. , 1971 , 19 , 1228 .
9.
Ball S.J.
,
Davis M.
,
Hodgson J. N.
,
Lucas J. M.
,
Parnell E. W.
,
Sharp B. W.
, and
Warburton D.
, Chem. Indu. , 1968 , 2 , 56 .
10.
Hodgson J.N.
, Br. Vet F. , 1968 , 124 , 209 .
11.
Tomio T.
,
Yoshikazu T.
,
Masa H.
;
Hiroshi N.
, and
Kiyoshi S.
, US Pat. , 5215981, 1990 .
12.
Li G.Q.
,
Kanu S.
,
Xiang F. Y.
,
Xiao S. M.
,
Zhang L.
,
Chen H. W.
, and
Ye H. J.
, Vet Para , 2004 , 119 , 261 .
13.
Folz S.D.
,
Lee B. L.
,
Nowakowski L. H.
,
Rector D. L.
, and
Folz B. M.
, J. Para , 1989 , 75 , 696 .
