Abstract
A series of substituted ethyl 4-hydroxy-11-oxo-11H-chromeno[2,3-g]quinoline-3-carboxylates were designed and synthesised as anticoccidial drugs, and the structures were characterised by 1H NMR, MS, IR spectra and elementary analysis. The anticocciadial activities of the new compounds were assessed according to the anticoccidial index method. The results demonstrated that four of these compounds exihibited effective anticoccidial activities against Eimeria tenella in chicken's diet with a dose of 27 mg kg−1.
References
1.
Yang Z.X.
,
Bi Y.Z.
,
Zou Y.
,
Hou T.P.
, and
Wang Y.L.
, Youji Huaxue , 2008 , 28 , 432 (in Chinese).
2.
Greif G.
,
Stephan B.
, and
Haberkorn A.
, Parasitol. Res. , 1996 , 8 , 706 .
3.
Xu J.J.
,
Tao J.P.
, and
Peng J.B.
, Anim. Husbandry Vet. Med. , 2008 , 40 , 18 .
4.
Armer R.E.
,
Dutton C.J.
,
Fenner B.R.
,
Greenwood S.D.W.
,
Hall K.T.
, and
Rudge A.J.
, Bioorg. Med. Chem. Lett. , 1998 , 8 , 139 .
5.
Gage J.L.
,
Kirst H.A.
,
O'Neil D.
,
David B.A.
,
Smith C.K. II
,
Naylor S.A.
, Bioorg. Med. Chem. Lett. , 2003 , 11 , 4083 .
6.
Feng D.
,
Fisher M.
,
Liang G.B.
,
Qian X.X.
,
Brown C.
,
Gurnett A.
,
Leavitt P.S.
,
Liberator P.A.
,
Mathew J.
,
Misura A.
,
Samaras S.
,
Tamas T.
,
Schmatz D.M.
,
Wyvratt M.
, and
Biftu T.
, Bioorg. Med. Chem. Lett. , 2006 , 16 , 5978 .
7.
QX.X.,
Liang G.B.
,
Feng D.
,
Fisher M.
,
CrumLey T.
,
Rattray S.
,
Dulski P.M.
,
Gurnett A.
,
Leavitt P.S.
,
Liberator P.A.
,
Misura A.S.
,
Samaras S.
,
Tamas T.
,
Schmatz D.M.
,
Wyvratt M.
, and
Biftu T.
, Bioorg. Med. Chem. Lett. , 2006 , 16 , 2817 .
8.
Liang G.B.
,
Qian X.X.
,
Feng D.
,
Fisher M.
,
Brown C.M.
,
Gurnett A.
,
Leavitt P.S.
,
Liberator P.A.
,
Misura A.S.
,
Tamas T.
,
Schmatz D.M.
,
Wyvratt M.
, and
Biftu T.
, Bioorg. Med. Chem. Lett. , 2007 , 17 , 3558 .
9.
Andrew S.
,
Richard D.
,
Hong J.
,
Lee S.
,
McIntyre D.
,
Perrey D.
,
Feng D.
,
Fisher M.
,
Wyvratt M.
,
Leavitt P.
,
Liberator P.
,
Gurnett A.
,
Brown C.
,
Mathew J.
,
Thompson D.
,
Schmatz D.
, and
Biftu T.
Eur. J. Med. Chem. , 2007 , 42 , 1334 .
10.
Scribner A.
,
Dennis R.
, and
Lee S.
, Eur. J. Med. Chem. , 2008 , 43 , 1123 .
11.
Scribner A.
,
Meitz S.
,
Fisher M.
,
Wyvratt M.
,
Leavitt P.
,
Liberator P.
,
Gurnett A.
,
Brown C.
,
Mathew J.
,
Thompson D.
,
Schmatz D.
, and
Biftu T.
, Bioorg. Med. Chem. Lett. , 2008 , 18 , 5263 .
12.
Yan C.R.
,
Xu J.
,
Weng Y.B.
,
Li J.
,
Wang Y.L.
,
Chen H.
, Chem. Biol. Drug. Des. , 2008 , 72 , 314 .
13.
You J.H.
,
Ye C.W.
,
Weng Y.B.
,
Mo X.H.
, and
Wang Y.L.
, ARKIVOC , 2008 , 17 , 1 .
14.
Ye C.W.
,
You J.H.
,
Li X.F.
,
You R.
,
Weng Y.B.
,
Li J.
,
Wang Y.L.
, Pestic. Biochem. Physiol. , 2010 , 97 , 194 .
15.
Zou Y.
,
Yan C.R.
,
Weng Y.B.
,
Li J.
,
Wu K.Q.
,
Wang Y.L.
, and
Wang Y.Z.
, J. Chem. Res. , 2009 , 33 , 252 .
16.
Yan C.R.
,
Zeng X.Y.
,
Yao Y.P.
,
Nie K.
, and
Wang Y.L.
, and
Wang Y.Z.
, J. Chem. Res. , 2010 , 34 , 71 .
17.
Zhang Y.Y.
,
Zeng X.Y.
,
Nie K.
,
Zhong Z.C.
,
Wang Y.L.
, and
Wang Y.Z.
, Chin. Chem. Res. , 2010 , 21 , 427 .
18.
Jia J.H.
,
Sheng W.J.
,
Chen B.
,
Gao J.R.
, J. Zhejiang Univ. Technol. , 2005 , 33 , 96 –99 .
19.
Wu K.Q.
,
Wang Y.L.
,
Zheng H.
, CN 1597657.
20.
Wright C.
,
Ullas G.V.
, J. Label Compd Radiopharm . 2002 , 45 , 1267 .
21.
Folz S.D.
,
Lee B.L.
,
Nowakowski L.H.
,
Rector D.L.
, and
Folz B.M.
, J. Parasitol. , 1989 , 75 , 696 .