Abstract
Seven novel pleuromutilin derivatives with thiazole-5-carboxamide and thioether moiety in the C14 side chain were designed and synthesised. The antibacterial activities of the target compounds were tested via agar-well diffusion method in vitro. The results showed that three target compounds still had antibacterial activity against Staphylococcus aureus ATCC26112 and Staphylococcus aureus SC at a low concentration of 0.05 μg mL−1.
References
1.
Kavanagh F.
,
Herxey A.
, and
Robbins W.J.
, Proc. Natl. Acad. Sci. USA , 1951 , 37 , 570 .
2.
Paquette L.A.
,
Wiedeman P.E.
, and
Bulman-Page P.C.
, J. Org. Chem. , 1988 , 53 , 1441 .
3.
Schlunzen F.
,
Pyetan E.
, and
Fucini P.
, Mol. Microbiol. , 2004 , 5 , 1287 .
4.
Anchel M.
, J. Biol. Chem. , 1952 , 199 , 133 .
5.
Hogenauer G.
, Eur. J. Biochem. , 1975 , 52 , 93 .
6.
Egger H.
, and
Reinshagen H.
, J. Antibiot. , 1976 , 29 , 923 .
7.
Burch D.G.
,
Jones G.T.
, and
Heard T.W.
, Vet. Rec. , 1986 , 119 , 108 .
8.
Drews J.
,
Georgopoulos A.
, and
Laber G.
, Antimicrob. Agents Chemother. , 1975 , 7 , 507 .
9.
Lolk L.
,
Pøhlsgaard J.
, and
Jepsen A.S.
, J. Med. Chem. , 2008 , 51 , 4957 .
10.
Berner H.
,
Fischer G.
, and
Hildebrandt J.F.
, Curr. Chemother. Immunother. , 1982 , 1 , 345 .
11.
Hirokawa Y.
,
Kinoshita H.
, and
Tanaka T.
, Bioorg. Med. Chem. Lett. , 2008 , 18 , 3556 .
12.
Draghi D.
,
Scangarella N.
, and
Shawar R.
, Washington D.C. , 2005 , Dec., 16.
13.
Hirokawa Y.
,
Kinoshita H.
, and
Tanaka T.
, J. Med. Chem. , 2008 , 51 , 1991 .
14.
Thirring K.
, and
Heilmayer W.
, 2009 , WO2009009812.
15.
Yao Y.P.
,
Dai F.Y.
, and
Wang Y.L.
, J. Chem. Res. , 2011 , 1 , 4 .
16.
Xu P.
,
Zhang Y.Y.
, and
Sun Y.X.
, Chem. Biol. Drug. Des. , 2009 , 73 , 655 .
17.
Xu K.P.
,
Zhang Y.Y.
, and
Luo J.
, J. Chem. Res. , 2010 , 6 , 354 .
18.
Zhang R.H.
,
Lu F.
, and
Zhu Z.L.
, Chem. Res. Appl. , 2006 , 18 , 186 .
19.
Rzasa R.M.
,
Kaller M.R.
, and
Liu G.
, Bioorg. Med. Chem. , 2007 , 15 , 6574 .
20.
Moody J.O.
,
Adebiyi O.A.
, and
Adeniyi B.A.
, J. Ethnopharmacol. , 2004 , 92 , 57 .
21.
Zheng S.Y.
,
Liu Q.H.
, and
Zhang G.Q.
, Acta Biochim. Pol. , 2010 , 57 , 43 .