Abstract
Ten novel pleuromutilin derivatives with quinazolinone and thioether groups in the C14 side chain have been designed and synthesised. The antibacterial activities of the target compounds were tested via the agar-well diffusion method in vitro in the concentration of 5.0 μg mL−1 The results showed that all target compounds had displayed obvious antibacterial activity against Staphylococcus aureus ATCC26112 and Staphylococcus aureus SC.
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