L-Proline Triflate as an Efficient and Reusable Catalyst for the One-Pot Synthesis of 2,4,5-Trisubstituted Imidazoles and 1,2,4,5-Tetrasubstituted Imidazoles
Free accessResearch articleFirst published online April, 2010
L-Proline Triflate as an Efficient and Reusable Catalyst for the One-Pot Synthesis of 2,4,5-Trisubstituted Imidazoles and 1,2,4,5-Tetrasubstituted Imidazoles
L-Proline triflate has been used as an efficient catalyst for an improved and rapid one-pot synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles in good yields. The benefit of this approach is its operational simplicity and the catalyst can be easily recovered and reused without any loss of activity.
LeeJ.C., LaydonJ. T., McDonnellP. C., GallagherT. F., KumarS., GreenD., McNultyD., BlumenthalM. J., KeysJ. R., VatterS. W. L., StricklerJ. E., McLaughlinM. M., SiemensI. R., FisherS. M., LiviG. P., WhiteJ. R., AdamsJ. L., and YoungP. R., Nature, 1994, 372, 739.
2.
TakleA.K., BrownM. J. B., DaviesS., DeanD. K., FrancisG., GaibaA., HirdA. W., KingF. D., LovellP. J., NaylorA., ReithA. D., SteadmanJ. G., and WilsonD. M., Bioorg. Med. Chem. Lett., 2006, 16, 378.
3.
Abdel-MeguidS.S., MetcalfB. W., CarrT. J., DemarshP., DesJarlaisR. L., FisherS., GreenD. W., IvanoffL., and LambertD. M., Biochemistry, 1994, 33, 11671.
4.
WangL., WoodsK. W., LiQ., BarrK. J., McCroskeyR. W., HannickS. M., GherkeL., CredoR. B., HuiY. H., MarshK., WarnerR., LeeJ. Y., Zielinsky- MozngN., FrostD., RosenbergS. H., and ShamH. L., J. Med. Chem., 2002, 45, 1697.
5.
HeeresJ., BackxL. J. J., MostmansJ. H., and Van CutsemJ., J. Med. Chem., 1979, 22, 1003.
6.
SchmiererR., MildenbergerH., HandteR., and BuerstellH., German Patent 3537290, 1987, Chem. Abstr.1988, 107, 198321.
7.
De LaszloS.E., HackerC., LiB., KimD., MacCossM., MantaloN., PivnichnyJ. V., ColwellL., KochG. E., CascieriM. A., and HagmennW. K., Bioorg. Med. Chem. Lett., 1999, 9, 641.
