Abstract
A new series of peptide 5-fluorouracil derivatives was designed and synthesised in order to test in vitro anticancer activities. The results indicated that peptide 5-fluorouracil derivatives possessed anticancer activities against human HL-60 and Bel-7402 cell lines. The structures of the compounds were determined by means of 1H NMR, 13C NMR, IR, mass spectra and elemental analyses.
References
1.
Maria C.
,
Fernando R. S.
,
Juan A.
,
Octavio C.
,
Antonia A.
,
Miguel A.
,
Antonio E.
, and
Joaquin M.
, Tetrahedron Lett. , 2007 , 63 , 183 .
2.
Ahmed S.
,
Hamdy M. R.
,
Nadia M.
, and
Mahmoud A.
, Bioorg. Med. Chem. , 2006 , 14 , 1236 .
3.
Hulme A.T.
,
Price S. L.
, and
Tocher D. A.
, J. Am. Chem. Soc. , 2005 , 127 , 1116 .
4.
Lehmler H.J.
, and
Parkin S.
, Acta. Cryst. , 2000 , C56 , e518 .
5.
Liu J.
,
Li X.
,
Cheng Y.
,
Cui S.
,
Chen M.
,
Xu W.
,
Tian Z.
,
Makuuchi M.
,
Tang W.
, and
Qu X.
, Eur J. Pharmacol. , 2007 , 574 , 1 .
6.
Cho Y.W.
,
Lee J. R.
, and
Song S. C.
, Bioconjugate Chem. , 2005 , 16 , 1529 .
7.
Liu Z.F.
, and
Rimmer S.
, J. Controll. Rel. , 2002 , 81 , 91 .
8.
Chen S.W.
,
Tian X.
, and
Tu Y. Q.
, Bioorg. Med. Chem. Lett. , 2004 , 14 , 5063 .
9.
Moyle P.M.
,
Olive C.
,
Ho M. F.
,
Good M. F.
, and
Toth I.
, J. Med. Chem. , 2006 , 49 , 6364 .
10.
Dahiya R.
, and
Pathak D.
, Eur J. Med. Chem. , 2007 , 42 , 772 .
11.
Hu M.L.
,
Yuan J. X.
, and
Morsali A.
, Solid State Sci. , 2006 , 8 , 981 .
12.
Yin P.
,
Hu M. L.
, and
Hu L. C.
, J. Mol Struct , 2008 , 882 , 75 .
13.
Yuan J.X.
,
Cai X. Q.
,
Chen D. M.
, and
Hu M. L.
, Chin. J. Chem. , 2007 , 25 , 417 .
14.
Liu X.
,
Chen R.
, and
Liu Y.
, Chem. J. Chin. U. , 2002 , 23 , 1299 .
15.
Rao G.W.
, and
Hu W. X.
, Bioorg. Med. Chem. Lett. , 2006 , 16 , 3702 .
16.
Chevrier C.
,
Defoin A.
, and
Tarnus C.
, Bioorg. Med. Chem. , 2007 , 15 , 4125 .