The preparation of two reduced pyrimidine derivatives, ethyl 3-acetyl-4-(4-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate and ethyl 4-(3,4-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylate, is described, along with details of their crystal structure analysis.
AtwalK., RovnyakG. C., SchwartzJ., MorelandS., HedbergA., GougoutasJ. Z., MalleyM. F., and FloydD. M., J. Med. Chem., 1990, 33, 1510.
4.
AtwalK., RovnyakG. C., KimballS. D., FloydD. M., MorelandS., SwansonS., GougoutasJ. Z., SchwartzJ., SmillieK. M., and MalleyM. F., J. Med. Chem., 1990, 33, 2629.
5.
AtwalK.S., SwansonB. N., UngerS. E., FloydD. M., MorelandS., HedbergA., and O'ReillyB. C., J. Med. Chem., 1991, 34, 806.
6.
RovnyakG.C., AtwalK. S., HedbergA., KimballS. D., MorelandS., GougoutasJ. Z., O'ReillyB. C., SchwartzJ., and MalleyM. F., J. Med. Chem., 1992, 35, 3254.
7.
GroverG.J., DzwonczykS., McMullenD. M., NormadinamC. S., SlephP. G., and MorelandS., J. Cardiovasc. Pharmacol., 1995, 26, 289.
8.
NegwerM., Organic-chemical drugs and their synonyms, Akademie Verlag, Berlin, 1994, 2558.
9.
RovnyakG.C., KimballS. D., BeyerB., CucinottaG., DiMarcoJ. D., GougoutasJ. Z., HedbergA., MalleyM., McCarthyJ. P., ZhangR., and MorelandS., J. Med. Chem., 1995, 38, 119.
10.
TriggleD.J., and PadmanabhanS., Chemtracts: Org. Chem., 1995, 8, 191.
11.
BiginelliP., Gazz. Chim. Ital., 1893, 23, 360.
12.
KappeC.O., Tetrahedron, 1993, 49, 6937.
13.
BegumN.S., and VasundharaD. E., Acta. Crystalogr, 2006, E62, o5796.
14.
BegumN.S., and VasundharaD. E., Acta. Crystalogr, 2007, E63, o3741.
15.
GourhariM., PradipK., and ChandraniG., Tetrahedron Lett., 2003, 44, 2757.
16.
FuN.Y., YuanY. F., CaoZ., WangS. W., WangJ. T., and PeppeC., Tetrahedron, 2002, 58, 4801.
17.
AkhtarM.S., SethM., and BhaduriA. P., Indian J. Chem. Sect. B, 1987, 26, 556.
18.
Bruker, SAINT PLUS 1998, Program for data reduction, Bruker Axs Inc., Madison, Wisconsin, USA.
19.
SheldrickG.M., SHELXS97 1997, Program for the solution of crystal structures, University of Göttingen, Germany
20.
SheldrickG.M., SHELXL97 1997, Program for crystal structure refinement, University of Gottingen, Germany.
21.
FarrugiaL.J., ORTEP-3 for WINDOWS-A Version of ORTEP-III with a Graphical User Interface (GUI). J. Appl. Cryst., 1997, 30, 565.
