Abstract
The Suzuki–Miyaura reaction of aryl iodides and aryl bromides was catalysed by Pd(OAc)2 (1 mol%) using K3PO4·3H2O (2 equiv) as base in dimethyl acetamide DMA-H2O (1 : 1) at room temperature. Changes in the loading of Pd(OAc)2 (from 1 mol% to 2 mol%), temperature (from room temperature to 80 °C) and the ratio of DMA to water (from 1 : 1 to 5 : 1) resulted in the successful coupling of activated aryl chlorides with phenylboronic acid.
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