Sage Journals: Discover world-class research

Abstract

Three-component reaction of cyclohexyl isocyanide, barbituric acid and different aldehydes, in a mixture of water: acetonitrile (1:1) as solvent, produces the corresponding N-cyclohexyl-N-[aryl-(2,4,6-trioxohexahydropyrimidin-5-yl)methyl]formamides in excellent yields.

Keywords

cyclohexyl isocyanide barbituric acid aldehydes three-component reaction

References

Weber

, Curr. Med. Chem., 2002, 9, 1241.

Armstrong

R.W.

, Combs

A.P.

, Tempest

P.A.

, Brown

S.D.

, and Keating

T.A.

, Acc. Chem. Res., 1996, 29, 123.

Ugi

, In Isonitrile Chemistry. Academic Press, London, 1971.

Ugi

, Lohberger

, and Karl

, Comprehensive Organic Synthesis, Trost

B.M.

, and Fleming

, Eds.; Pergamon: New York, 1993; Vol. 2. Chap. 4.6, p. 1083.

Domling

, and Ugi

, Angew. Chem. Int. Ed., 2000, 39, 3168.

Shaabani

, Soleimani

, and Darvishi

, Chem. Monthly, 2007, 138, 43.

Ralhan

, and Ray

N.K.

, Theochem., 2003, 83.

Funda

, and Dogan

, Spectros. Lett., 2004, 37, 607.

Krasnov

K.A.

, Kartsev

V.G.

, and Santarovich

E.E.

, Chem. Heterocyc. Compd., 2002, 38, 702.

10.

Wang Jing-jun

, Zhou

, Zang

, Wang

, Gao

, and Cui

, Synth. Commun., 2005, 35, 2759.

Three-component reaction of Cyclohexyl Isocyanide,Barbituric Acid and Aryl Aldehydes;Synthesis of N -cyclohexyl- N -[aryl-(2,4,6-trioxohexahydropyrimidin-5-yl)methyl]formamides

Abstract

Keywords

References