Three-component reaction of Cyclohexyl Isocyanide,Barbituric Acid and Aryl Aldehydes;Synthesis of N -cyclohexyl- N -[aryl-(2,4,6-trioxohexahydropyrimidin-5-yl)methyl]formamides

Abstract

Three-component reaction of cyclohexyl isocyanide, barbituric acid and different aldehydes, in a mixture of water: acetonitrile (1:1) as solvent, produces the corresponding N-cyclohexyl-N-[aryl-(2,4,6-trioxohexahydropyrimidin-5-yl)methyl]formamides in excellent yields.