Synthesis of 1-[aryl-(pyrimidin-2-ylamino)-methyl]-naphthalen-2-ols by p -toluenesulfonic acid catalysed reaction between 2-naphthol,aromatic aldehydes and 2-aminopyrimidine

Abstract

Three-component reaction between 2-naphthol, an aromatic aldehyde and 2-aminopyrimidine catalysed by p-toluenesulfonic acid provided a simple and efficient one-pot route for the synthesis of 1-[aryl-(pyrimidin-2-ylamino)-methyl]-naphthalen-2-ol derivatives in excellent yields.