tert-Butyl isocyanide undergoes a smooth reaction with 5-benzylidene-2,2-dimethyl-1,3-dioxane-4,6-diones (benzylidene Meldrum's acids) in the presence of ethane-1,2-diol or catechol to produce functionalised N-tert-butyl-2-(5,7-dioxo-1,4-dioxepane-6-yl)-2-aryl-ethanamides or bis-(2-hydroxyphenyl) 2-[2-(tert-butylamino)-1-aryl-2-oxoethyl]-malonates in good yields.
YavariI., and HabibiA., Polish J. Chem., 2004, 78, 71.
6.
YavariI., and HabibiA., Synthesis, 2004, 989.
7.
YavariI., HabibiA., and Hosseini-TabatabaeiM.R., Monatsh. Chem., 2003, 134, 1651.
8.
YavariI., Hosseini-TabatabaeiM.R., and HabibiA., Synthetic Commun., 2003, 33, 2709.
9.
When the reaction was carried out in the presence of 1 equivalent of 5, the major product was 6 and no bycyclic product corresponding to 4 was observed in the reaction mixture.
