Abstract
The reaction between alkyl isocyanides and substituted-benzylidene Meldrum's acid derivatives in the presence of water produces 4-(alkylamino)-3-aryl-4-oxobutanoic acids in good yields.
Keywords
References
1.
Meldrum A.N.
, J. Chem. Soc. , 1908 , 93 , 598 .
2.
Shaabani A.
,
Yavari I.
,
Teimouri M. B.
,
Bazgir A.
, and
Bijanzadeh H. M.
, Tetrahedron , 2001 , 57 , 1375 .
3.
Kameo K.
,
Ogawa K.
,
Takeshita K.
,
Nakaike S.
,
Tomisawa K.
, and
Sota K.
, Chem. Pharm. Bull. , 1988 , 36 , 2050 .
4.
Tomisawa K.
,
Kameo K.
,
Matsunaga T.
,
Saito S.
,
Hosoda K.
,
Asami Y.
, and
Sota K.
, Chem. Pharm. Bull. , 1985 , 33 , 2386 .
5.
Kameo K.
,
Takeshita K.
,
Yasuda Y.
,
Matsumoto K.
, and
Tomisawa K.
, Chem. Pharm. Bull. , 1996 , 44 , 602 .
6.
Domling A.
, and
Ugi I.
, Angew. Chem. Int. Ed. , 2000 , 39 , 3168 .
7.
Ugi I.
, Isonitrile Chemistry , Academic Press , 1971 .
8.
Yavari I.
,
Shaabani A.
, and
Maghsoodlou M. T.
, Monatsh. Chem. , 1997 , 128 , 697 .
9.
Yavari I.
,
Shaabani A.
,
Asghari S.
,
Olmsted M.
, and
Safari N.
, J. Fluorine Chem. , 1997 , 86 , 77 .
10.
Shaabani A.
, and
Farrokhzad F.
, J. Chem. Research (S) , 1997 , 344 .
11.
Shaabani A.
,
Ajabi S.
,
Farrokhzad F.
, and
Bijanzadeh H. M.
, J. Chem. Research (S) , 1999 , 582 .
12.
Figueroa-Villar J.D.
,
Carneiro C. L.
, and
Cruz E. R.
, Heterocycles , 1992 , 34 , 891 .
13.
Hedge J.A.
,
Kruse C. W.
, and
Snyder H. R.
, J. Org. Chem. , 1961 , 26 , 3166 .