The safety of 2,3-Naphthalenediol has not been documented and substantiated. The Cosmetic Ingredient Review Expert Panel cannot conclude that t-Butyl Hydroquinone is safe for use in cosmetic products until such time as the appropriate safety data have been obtained and evaluated. The data that were available are documented in the report, as well as the types of data that are required before a safety evaluation may be undertaken.
References
1.
1. Estrin, N.F., Crosley, P.A., and Haynes, C.R. (1982). CTFA Cosmetic Ingredient Dictionary, 3rd ed. Washington, DC: Cosmetic, Toiletry and Fragrance Association, p. 179.
2.
2. Chiavari, G., Concialini, V., and Vitali, P. (1982). High-performance liquid chromatography of some hydroxy-substituted aromatic compounds. J. Chromatogr.242(2), 385–92.
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3. Dinardo, J.C., Pacciano, J.C., Schnetzinger, R.W., Morris, W.E., and Wolf, B.A. (1985). Teratological assessment of five oxidative hair dyes in the rat. Toxicol. Appl. Pharmacol.78, 163–6.
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4. Food And Drug Administration (FDA). (1986). Cosmetic product formulation data-ingredients used in each product category. Section 06A: Hair dye. Washington, DC: Computer printout
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5. Weil, C.S. (1952). Tables for convenient calculation of median effective dose (LD50, ED50) and instruction for their use. Biometrics8, 249–63.
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6. Cosmetic, Toiletry And Fragrance Association (CTFA). (Jan. 20, 1982). Submission of unpublished data by CTFA. CIR safety data test summary response form. Acute oral toxicity test. CTFA Code No. 3-14-1.*
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7. CTFA. (Dec. 20, 1978). Submission of unpublished data by CTFA. CIR safety data test summary response form. Rabbit eye irritation. CTFA Code No. 3-14-2.*
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8. Registry Of Toxic Effects Of Chemical Substances. (1982). National Institute for Occupational Safety and Health. U.S. Dept. of Health and Human Services, p. 796.
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9. Draize, J.H. (1959). Dermal toxicity. In: Appraisal of the Safety of Chemicals, Foods, Drugs, and Cosmetics. Austin, TX: Association of Food and Drug Officials of the US, pp. 46–59.
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10. CTFA. (Nov. 4, 1979). Submission of unpublished data by CTFA. CIR safety data test summary response form. Contact allergy testing in guinea pigs. CTFA Code No. 3-14-4.*
12. CTFA. (July 3, 1979). Submission of unpublished data by CTFA. CIR safety data test summary response form. Ames testing. CTFA Code No. 3-14-5.*
13.
13. CTFA. (Dec. 13, 1982). Submission of unpublished data by CTFA. CIR safety data test summary response form. Human patch-single insult. CTFA Code No. 3-14-3.*
