Two general approaches to research in the field of toxicology are discussed and. their merits evaluated relative to the elucidation of those parameters which may play an important role on the extrapolation of animal data to human health effects. A number of these parameters are discussed relative to the ability to maintain fidelity of genetic information.
References
1.
1. Hart, R.W. and Turturro, A. (1981). Evolution and longevity-assurance processes. Naturwissen-schaften68, 552–557.
2.
2. Bourliere, F. (1962). Comparative longevity of higher vertebrates, in: Biological Aspects of Aging. N. Schock. (ed.). Columbia University Press: New York. pp. 3–21.
3.
3. Burch, P.P. (1968). In: An Inquiry Concerning Growth, Disease, and Aging. Oliver and Boyd: Edin-burg.
4.
4. Hart, R.W., Sacher, G.A., and Hoskins, T.L. (1979). DNA repair in short- and long-lived rodent species. J. Geron.34(1), 808–817.
5.
5. Cutler, R.G. (1976). Evolution of human longevity and the genetic complexity governing aging rats. Proc. Natl. Acad. Sci. USA72, 4664–4668.
6.
6. Brash, D.E. and Hart, R.W. (1978). DNA damage and repair in vivo?. J. Env. Path. Tox.2, 79–114.
7.
7. Sacher, G.A. (1975). Maturation and longevity in relation to cranial capacity in hominid evolution, in: Antecedents of Man and After I. Primates: Functional Morphology and Evolution. R. Tuttle. (ed.). The Hague: Mouton Publishers, pp. 417–441.
8.
8. Trosko, J.E. and Hart, R.W. (1976). DNA mutation frequencies in mammals, in: Interdisciplinary Topics in Gerontology. Vol. 9. R. G. Cutler (ed.). Kurger: Basel, pp. 168–197.
9.
9. Hart, R.W., Hall, K.Y., and Daniel, F.B. (1978). DNA repair and mutagenesis in mammalian cells. Photochem. Photobiol.28, 131–155.
10.
10. Brash, D.E. and Hart, R.W. (1978). Molecular biology of aging, in: The Biology of Aging. J. A. Behnke, C. E. Finch, and G. B. Moment (eds.). Plenum Publishing Corp.: New York. pp. 57–81.
