Although children with osteosarcoma have a higher incidence of a 2nd malignancy than the general population, its development in the lung is rare. The few reported cases belong to examples of carcinomas. Here we present the case of a 13-year-old boy with a primary pulmonary adenocarcinoma diagnosed 3 years after the osteosarcoma diagnosis and present a review of the literature.
BriccoliARoccaMSaloneM. Resection of recurrent pulmonary metastases in patients with osteosarcoma. Cancer2005; 104:1721–1725.
2.
van GeelANPastorinoUJauchKW. Surgical treatment of lung metastases: The European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group study of 255 patients. Cancer1996;7:675–682.
3.
NeusuessAClaviezASchroeterTHarmsDSuttorpM. Synchronous detection of a pulmonary papillary adenoma and lung metastases in a patient with osteosarcoma in relapse. Med Pediatr Oncol2002;38:125–127.
4.
LebensburgerJKatzensteinHJenkinsJJRodriguez-GalindoC. Bronchioloalveolar carcinoma as a second malignancy in osteosarcoma survivors. Pediatr Blood Cancer2009;53:499–501.
5.
LonghiABertoniFBacchiniPAlbisinniUMercatiUBacciG. Simultaneous osteosarcoma lung metastasis and second primary lung cancer. J Pediatr Hematol Oncol2004;26:457–461.
6.
ShiraishiKMoriTOhbaYIwataniKYoshimotoKIyamaK. Three young osteosarcoma patients with small adenocarcinoma or atypical adenomatous hyperplasia of the lung. Ann Thorac Cardiovasc Surg2010;16:358–361.
7.
KaytonMLHeMZakowskiMF. Primary lung adenocarcinomas in children and adolescents treated for pediatric malignancies. J Thorac Oncol2010;5:1764–1771.
8.
PetrilliASde CamargoBFilhoVO. Results of the Brazilian Osteosarcoma Treatment Group Studies III and IV: prognostic factors and impact on survival. J Clin Oncol2006;24:1161–1168.
9.
PenzelRSersCChenY. EGFR mutation detection in NSCLC: assessment of diagnostic application and recommendations of the German Panel for Mutation Testing in NSCLC. Virchows Arch2011;458:95–98.
10.
TravisWDBrambillaENoguchiM. International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma. J Thorac Oncol2011;6:244–285.
11.
BacciGFerrariCLonghiA. Second malignant neoplasm in patients with osteosarcoma of the extremities treated with adjuvant and neoadjuvant chemotherapy. J Pediatr Hematol Oncol2006;28:774–780.
12.
AungLGorlickRGShiW. Second malignant neoplasms in long-term survivors of osteosarcoma: Memorial Sloan-Kettering Cancer Center experience. Cancer2002;95:1728–1734.
13.
PrattCBMeyerWHLuoX. Second malignant neoplasms occurring in survivors of osteosarcoma. Cancer1997;80:960–965.
14.
YoshizawaASumiyoshiSSonobeM. Validation of the IASLC/ATS/ERS lung adenocarcinoma classification for prognosis and association with EGFR and KRAS gene mutations: analysis of 440 Japanese patients. J. Thorac Oncol2013;8:52–61.
15.
KaytonMLHeMZakowskiMF. Primary lung adenocarcinomas in children and adolescents treated for pediatric malignancies. J Thorac Oncol2010;5:1764–1771.
16.
KodamaKHigashiyamaMTakamiKHigakiNOdaKArakiN. Synchronous pulmonary atypical adenomatous hyperplasia and metastatic osteosarcoma in a young female. Jpn J Thorac Cardiovasc Surg2004;52:357–359.
17.
NonomuraAMizukamiYShimizuJ. Simultaneous occurrence of lung adenocarcinoma and fibular osteosarcoma in a 13-year-old girl. Thorac Cardiovasc Surg1994;42:61–63.