Benzyl alcohol is a weak sensitizer found in a wide array of plants and plant products, foods, cosmetics, and medications. Delayed contact dermatitis reactions as well as immediate, urticarial, and systemic reactions have been reported to occur with its use in these various formulations. We present the case of a woman with allergic contact dermatitis from benzyl alcohol and provide a brief review of allergy to this chemical.
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References
1.
NairB. Final report on the safety assessment of benzyl alcohol, benzoic acid, and sodium benzoate. Int J Toxicol, 2001; 20Suppl 3: 23-50.
2.
MitchellDM, BeckMH. Contact allergy to benzyl alcohol in a cutting oil reodorant. Contact Dermatitis, 1988; 18:301-2.
3.
ShawDW. Allergic contact dermatitis to benzyl alcohol in a hearing aid impression material. Am J Contact Dermat, 1999; 10:228-32.
4.
FlyvholmMA. Contact allergens in registered chemical products. Contact Dermatitis, 1991; 25:49-56.
5.
De GrootA, BosJD, JagtmanBA, et al.Contact allergy to preservatives-II. Contact Dermatitis, 1986; 15:218-22.
6.
CorazzaM, MantovaniL, MaraniniC, et al.Allergic contact dermatitis from benzyl alcohol. Contact Dermatitis, 1996; 34:74-5.
7.
Cosmetic, Toiletry and Fragrance Association. Available at: https://www.ctfa.org (accessed October24, 2005).
8.
BrownWJ, BuistNR, GipsonHT, et al.Fatal benzyl alcohol poisoning in a neonatal intensive care unit. Lancet, 1982; 1:1250.
9.
LeBelM, FerrronL, MassonM, et al.Benzyl alcohol metabolism and elimination in neonates. Dev Pharmacol Ther, 1988; 11:347-56.
10.
GoossensA, ClaesL, DriegheJ, et al.Antimicrobials: preservatives, antiseptics, and disinfectants. Contact Dermatitis, 1998; 39:133-4.
11.
SestiniS, MoriM, FrancalanciS. Allergic contact dermatitis from benzyl alcohol in multiple medicaments. Contact Dermatitis, 2004; 50:316-7.
12.
ShojiA. Allergic reaction to benzyl alcohol in an antimycotic preparation. Contact Dermatitis, 1983; 9:510.
13.
WurbachG, SchubertH, PhillippI. Contact allergy to benzyl alcohol and benzyl paraben. Contact Dermatitis, 1993; 28:187-8.
14.
PoddaM, ZollnerT, Grundmann-KollmannM, et al.Allergic contact dermatitis from benzyl alcohol during topical antimycotic treatment. Contact Dermatitis, 1999; 41:302-3.
AguirreA, OleagaJM, ZabalaR, et al.Allergic contact dermatitis from Reflex spray. Contact Dermatitis, 1994; 30:52-3.
17.
ShmunesE. Allergic dermatitis to benzyl alcohol in an injectable solution. Arch Dermatol, 1984; 120:1200-1.
18.
LazzariniS. Contact allergy to benzyl alcohol and isopropyl palmitate, ingredients of topical corticosteroid. Contact Dermatitis, 1982; 8:349-50.
19.
TaylorJS, MaibachHI, FisherAA, et al.Contact leukoderma associated with the use of hair colors. Cutis, 1993; 52:273-80.
20.
LodiA, ManciniLL, PozziM, et al.Occupational airborne allergic contact dermatitis in parquet layers. Contact Dermatitis, 1993; 29:281-2.
21.
EmmonsWW, MarksJGJr. Immediate and delayed reactions to cosmetic ingredients. Contact Dermatitis, 1985; 13:258-65.
22.
FisherAA. Allergic paraben and benzyl alcohol hypersensitivity relationship of the “delayed” and “immediate” varieties. Contact Dermatitis, 1975; 1:281-4.
23.
EdwardsEK Jr. Allergic reactions to benzyl alcohol in a sunscreen. Cutis, 1981; 28:332-2.
24.
HausenBM. Contact allergy to balsam of Peru. II. Patch test results in 102 patients with selected balsam of Peru constituents. Am J Contact Dermat, 2001; 12:93-102.
25.
GuinJD, GoodmanJ. Contact urticaria from benzyl alcohol presenting as intolerance to saline soaks. Contact Dermatitis, 2001; 45:182-3.
26.
GrantJA, BilodeauPA, GuernseyBG, et al.Unsuspected benzyl alcohol hypersensitivity. N Engl J Med, 1982; 306:108.
27.
VereckenP, BirringerC, KniteliusAC, et al.Sensitization to benzyl alcohol: a possible cause of “corticosteroid allergy.”. Contact Dermatitis, 1998; 38:106.
28.
CommandeurC, RichardM, RenziPM. Severe hypersensitivity reaction to injectable gallium 67 in a worker exposed to silica. Allergy, 1992; 47:337-9.
