Nuclear receptors are DNA-binding transcription factors, the transcriptional function of many of which depends on the binding of ligands, a feature that distinguishes nuclear receptors from other transcription factors. This review will summarize recent advances in our knowledge of the interaction between selected nuclear receptors and their cognate ligands.
References
1.
DarimontB. D., WagnerR. L., AprilettiJ. W., StallcupM. R., KushnerP. J., BaxterJ. D., FletterickR. J., and YamamotoK. R. (1998). Structure and specificity of nuclear receptor-coactivator interactionsGenes Dev12, 3343–56.
2.
GampeR.T.Jr., MontanaV. G., LambertM. H., MillerA. B., BledsoeR. K., MilburnM. V., KliewerS. A., WillsonT. M., and XuH. E. (2000). Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptorsMol Cell5, 545–55.
3.
HuX., and LazarM. A. (2000). Transcriptional repression by nuclear hormone receptorsTrends Endocrinol Metab11, 6–10.
4.
IssemannI., and GreenS. (1990). Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferatorsNature347, 645–50.
5.
KallenbergerB. C., LoveJ. D., ChatterjeeV. K., and SchwabeJ. W. (2003). A dynamic mechanism of nuclear receptor activation and its perturbation in a human diseaseNat Struct Biol10, 136–40.
NolteR. T., WiselyG. B., WestinS., CobbJ. E., LambertM. H., KurokawaR., RosenfeldM. G., WillsonT. M., GlassC. K., and MilburnM.V. (1998). Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γNature395, 137–43.
8.
PerissiV., StaszewskiL. M., McInerneyE. M., KurokawaR., KronesA., RoseD. W., LambertM. H., MilburnM. V., GlassC. K., and RosenfeldM. G. (1999). Molecular determinants of nuclear receptor-corepressor interactionGenes Dev13, 3198–208.
9.
ShiauA. K., BarstadD., LoriaP. M., ChengL., KushnerP. J., AgardD. A., and GreeneG. L. (1998). The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifenCell95, 927–37.
10.
XuH. E., LambertM. H., MontanaV. G., ParksD. J., BlanchardS. G., BrownP. J., SternbachD. D., LehmannJ. M., WiselyG. B., and WillsonT. M. (1999). Molecular recognition of fatty acids by peroxisome proliferator-activated receptorsMol Cell3, 397–403.
11.
XuH. E., LambertM. H., MontanaV. G., PlunketK. D., MooreL. B., CollinsJ. L., OplingerJ. A., KliewerS. A., GampeR. T.Jr., and McKeeD. D. (2001). Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptorsProc Natl Acad Sci U S A98, 13919–24.
12.
XuH. E., StanleyT. B., MontanaV. G., LambertM. H., ShearerB. G., CobbJ. E., McKeeD. D., GalardiC. M., PlunketK. D., NolteR. T., ParksD. J., MooreJ. T., KliewerS. A., WillsonT. M., and StimmelJ. B. (2002). Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalphaNature415, 813–7.
